The Making of a Fly

The Genetics of Animal Design

Author: P. A. Lawrence

Publisher: Wiley-Blackwell

ISBN: 9780632030484

Category: Science

Page: 240

View: 8209

Understanding how a multicellular animal develops from a single cell (the fertilized egg) poses one of the greatest challenges in biology today. Development from egg to adult involves the sequential expression of virtually the whole of an organism's genetic instructions both in the mother as she lays down developmental cues in the egg, and in the embryo itself. Most of our present information on the role of genes in development comes from the invertebrate fruit fly, Drosophila. The two authors of this text (amongst the foremost authorities in the world) follow the developmental process from fertilization through the primitive structural development of the body plan of the fly after cleavage into the differentiation of the variety of tissues, organs and body parts that together define the fly. The developmental processes are fully explained throughout the text in the modern language of molecular biology and genetics. This text represents the vital synthesis of the subject that many have been waiting for and it will enable many specific courses in developmental biology and molecular genetics to focus on it. It will appeali to 2nd and 3rd year students in these disciplines as well as in biochemistry, neurobiology and zoology. It will also have widespread appeal among researchers. Authored by one of the foremost authorities in the world. A unique synthesis of the developmental cycle of Drosophila - our major source of information on the role of genes in development. Designed to provide the basis of new courses in developmental biology and molecular genetics at senior undergraduate level. A lucid explanation in the modern language of the science.

The Evolutionary Biology of Flies

Author: David K. Yeates,Brian M. Wiegmann

Publisher: Columbia University Press

ISBN: 0231127006

Category: Science

Page: 430

View: 8058

Classical Japanese: A Grammar is a comprehensive, and practical guide to classical Japanese. Extensive notes and historical explanations make this volume useful as both a reference for advanced students and a textbook for beginning students. The volume, which explains how classical Japanese is related to modern Japanese, includes detailed explanations of basic grammar, including helpful, easy-to-use tables of grammatical forms; annotated excerpts from classical premodern texts. Classical Japanese: A Grammar - Exercise Answers and Tables (ISBN: 978-0-231-13530-6) is now available for purchase as a separate volume.

Molekulare Zellbiologie

Author: Arnold Berk,David Baltimore,Harvey Lodish,James Darnell,Paul Matsudaira,S. Lawrence Zipursky

Publisher: Walter de Gruyter

ISBN: 3110810573

Category: Science

Page: 1491

View: 319


Insect Molecular Genetics

An Introduction to Principles and Applications

Author: Marjorie A. Hoy

Publisher: Academic Press

ISBN: 0240821319

Category: Science

Page: 838

View: 7762

Insect Molecular Genetics, Third Edition, summarizes and synthesizes two rather disparate disciplines—entomology and molecular genetics. This volume provides an introduction to the techniques and literature of molecular genetics; defines terminology; and reviews concepts, principles, and applications of these powerful tools. The world of insect molecular genetics, once dominated by Drosophila, has become much more diverse, especially with the sequencing of multiple arthropod genomes (from spider mites to mosquitoes). This introduction includes discussion of honey bees, mosquitoes, flour beetles, silk moths, fruit flies, aphids, house flies, kissing bugs, cicadas, butterflies, tsetse flies and armyworms. This book serves as both a foundational text and a review of a rapidly growing literature. With fully revised and updated chapters, the third edition will be a valuable addition to the personal libraries of entomologists, geneticists, and molecular biologists. Up-to-date references to important review articles, websites, and seminal citations in the disciplines Well crafted and instructive illustrations integral to explaining the techniques of molecular genetics Glossary of terms to help beginners learn the vocabulary of molecular biology

Philosophy of Experimental Biology

Author: Marcel Weber

Publisher: Cambridge University Press

ISBN: 9781139453912

Category: Science

Page: N.A

View: 7162

Philosophy of Experimental Biology explores some central philosophical issues concerning scientific research in experimental biology, including genetics, biochemistry, molecular biology, developmental biology, neurobiology, and microbiology. It seeks to make sense of the explanatory strategies, concepts, ways of reasoning, approaches to discovery and problem solving, tools, models and experimental systems deployed by scientific life science researchers and also integrates developments in historical scholarship, in particular the New Experimentalism. It concludes that historical explanations of scientific change that are based on local laboratory practice need to be supplemented with an account of the epistemic norms and standards that are operative in science. This book should be of interest to philosophers and historians of science as well as to scientists.

Towards a Theory of Development

Author: Alessandro Minelli,Thomas Pradeu

Publisher: OUP Oxford

ISBN: 0191651184

Category: Science

Page: 320

View: 7566

Is it possible to explain and predict the development of living things? What is development? Articulate answers to these seemingly innocuous questions are far from straightforward. To date, no systematic, targeted effort has been made to construct a unifying theory of development. This novel work offers a unique exploration of the foundations of ontogeny by asking how the development of living things should be understood. It explores the key concepts of developmental biology, asks whether general principles of development can be discovered, and examines the role of models and theories. The two editors (one a biologist with long interest in the theoretical aspects of his discipline, the other a philosopher of science who has mainly worked on biological systems) have assembled a team of leading contributors who are representative of the scientific and philosophical community within which a diversity of thoughts are growing, and out of which a theory of development may eventually emerge. They analyse a wealth of approaches to concepts, models and theories of development, such as gene regulatory networks, accounts based on systems biology and on physics of soft matter, the different articulations of evolution and development, symbiont-induced development, as well as the widely discussed concepts of positional information and morphogenetic field, the idea of a 'programme' of development and its critiques, and the long-standing opposition between preformationist and epigenetic conceptions of development. Towards a Theory of Development is primarily aimed at students and researchers in the fields of 'evo-devo', developmental biology, theoretical biology, systems biology, biophysics, and the philosophy of science.

Anschauung denken

Zum Ansatz einer Morphologie des Unmittelbaren

Author: Olaf Breidbach,Federico Vercellone

Publisher: Wilhelm Fink Verlag

ISBN: 3770552490

Category: Aesthetics, Modern

Page: 182

View: 4652

Bilder schauen wir an, unser Anschauen scheint durch diese Bilder geführt. In der immer stärker anwachsenden Flut solcher Bilder scheint unser Denken mehr und mehr durch dieses Anschauen bestimmt. Dabei offeriert diese Flut meist nur ein Spiel mit bekannten Formen, die variiert und in vielleicht verblüffender Weise präsentiert werden. Oft sind es dabei aber nur Illustrationen, die einen bekannten Gedanken untersetzen. Wo die Bilder aber in Neuland führen, wo sie uns etwas entdecken lassen, ist die Situation anders. Das Bild – und dies interessiert im vorliegenden Band – hat aber seine eigene Logik. Diese Logik ist nicht einfach die, die wir mit dem Bild illustrieren. Es formt sich nach den uns eigenen Anschauungen und leitet uns dann auch in unserem Denken über die Dinge. In ihm meinen wir denn auch Neues entdecken zu können, auf etwas verwiesen zu sein, was wir uns eben nicht schon immer gedacht haben. Wie kommen wir aber eigentlich an solch Neues, wie können wir etwas erkennen, von dem wir noch keinen Begriff haben? Werden wir im Denken solcher Neuigkeiten durch die Anschauung geführt? Greifen wir hier vor das aus, was wir schon begriffen haben? Wenn dies so ist, müssen wir Anschauungen zu denken lernen. Anschauungen zu denken, heißt dann aber nicht einfach zu illustrieren, was wir begriffen haben. Anschauung zu denken, heißt, vor den Begriff zu schauen. Das vorliegende Buch sucht hier nach ersten Antworten.

Morphomechanics of Development

Author: Lev V. Beloussov

Publisher: Springer

ISBN: 3319139908

Category: Science

Page: 195

View: 8204

This book outlines a unified theory of embryonic development, assuming morphogenesis to be a multi-level process including self-organizing steps while also obeying general laws. It is shown how molecular mechanisms generate mechanical forces, which in the long run lead to morphological changes. Questions such as how stress-mediated feedback acts at the cellular and supra-cellular levels and how executive and regulatory mechanisms are mutually dependent are addressed, while aspects of collective cell behavior and the morphogenesis of plants are also discussed. The morphomechanical approach employed in the book is based on the general principles of self-organization theory.

Das egoistische Gen

Mit einem Vorwort von Wolfgang Wickler

Author: Richard Dawkins

Publisher: Springer-Verlag

ISBN: 3642553915

Category: Science

Page: 489

View: 2942

p”Ein auch heute noch bedeutsamer Klassiker“ Daily Express Sind wir Marionetten unserer Gene? Nach Richard Dawkins ́ vor über 30 Jahren entworfener und heute noch immer provozierender These steuern und dirigieren unsere von Generation zu Generation weitergegebenen Gene uns, um sich selbst zu erhalten. Alle biologischen Organismen dienen somit vor allem dem Überleben und der Unsterblichkeit der Erbanlagen und sind letztlich nur die "Einweg-Behälter" der "egoistischen" Gene. Sind wir Menschen also unserem Gen-Schicksal hilflos ausgeliefert? Dawkins bestreitet dies und macht uns Hoffnung: Seiner Meinung nach sind wir nämlich die einzige Spezies mit der Chance, gegen ihr genetisches Schicksal anzukämpfen.

Animal Evolution

Genomes, Fossils, and Trees

Author: Maximilian J. Telford,D. Timothy J. Littlewood

Publisher: Oxford University Press

ISBN: 0199549427

Category: Science

Page: 245

View: 1358

Describing and understanding the evolution of the diversity of bodyplans is a major goal of evolutionary biology. Taking a modern, integrated approach to this question, a group of leading researchers describe how modern techniques and disciplines have been combined, resulting in a dramatic renaissance in the study of animal evolution.

General and Systematic Pathology E-Book

Author: James C. E. Underwood,Simon S Cross

Publisher: Elsevier Health Sciences

ISBN: 143772874X

Category: Medical

Page: 860

View: 2836

This highly acclaimed textbook is written specifically for students of medicine and related health science subjects. It progresses from a review of general pathology principles and disease mechanisms through detailed discussions of the pathologic entities associated with each organ system. Nearly 700 full-color photographs and pathology slides bring the content to life. The fifth edition features extensive updates throughout to reflect the latest discoveries in cellular and molecular pathology, and offers a web site that presents self-assessment material and illustrated clinical case studies. Contents perfectly matches needs on medical students. Very clinical approach matches integrated courses. Extensive International Advisory Board validates contents. Each organ system chapter begins with a brief review of normal structure and function, emphasizing aspects that are important to an understanding of the subsequently discussed disease processes. Offers a superb collection of clinical photographs, histopathology images, and graphics, approximately 700 in all, that richly depict the appearance of both healthy and diseased tissues. New co-editor, Dr Simon Cross. Structure of chapters revised to make the book much easier to use during courses that are problem- or case-based. Several new contributors and re-written chapters. Expanded International Advisory Board.

Eine kurze Geschichte der Menschheit

Author: Yuval Noah Harari

Publisher: DVA

ISBN: 364110498X

Category: History

Page: 528

View: 9515

Krone der Schöpfung? Vor 100 000 Jahren war der Homo sapiens noch ein unbedeutendes Tier, das unauffällig in einem abgelegenen Winkel des afrikanischen Kontinents lebte. Unsere Vorfahren teilten sich den Planeten mit mindestens fünf weiteren menschlichen Spezies, und die Rolle, die sie im Ökosystem spielten, war nicht größer als die von Gorillas, Libellen oder Quallen. Vor 70 000 Jahren dann vollzog sich ein mysteriöser und rascher Wandel mit dem Homo sapiens, und es war vor allem die Beschaffenheit seines Gehirns, die ihn zum Herren des Planeten und zum Schrecken des Ökosystems werden ließ. Bis heute hat sich diese Vorherrschaft stetig zugespitzt: Der Mensch hat die Fähigkeit zu schöpferischem und zu zerstörerischem Handeln wie kein anderes Lebewesen. Anschaulich, unterhaltsam und stellenweise hochkomisch zeichnet Yuval Harari die Geschichte des Menschen nach und zeigt alle großen, aber auch alle ambivalenten Momente unserer Menschwerdung.

Befreit

Wie Bildung mir die Welt erschloss

Author: Tara Westover

Publisher: Kiepenheuer & Witsch

ISBN: 3462316680

Category: Biography & Autobiography

Page: 448

View: 3784

Von den Bergen Idahos nach Cambridge – der unwahrscheinliche »Bildungsweg« der Tara Westover. Tara Westover ist 17 Jahre alt, als sie zum ersten Mal eine Schulklasse betritt. Zehn Jahre später kann sie eine beeindruckende akademische Laufbahn vorweisen. Aufgewachsen im ländlichen Amerika, befreit sie sich aus einer ärmlichen, archaischen und von Paranoia und Gewalt geprägten Welt durch – Bildung, durch die Aneignung von Wissen, das ihr so lange vorenthalten worden war. Die Berge Idahos sind Taras Heimat, sie lebt als Kind im Einklang mit der grandiosen Natur, mit dem Wechsel der Jahreszeiten – und mit den Gesetzen, die ihr Vater aufstellt. Er ist ein fundamentalistischer Mormone, vom baldigen Ende der Welt überzeugt und voller Misstrauen gegenüber dem Staat, von dem er sich verfolgt sieht. Tara und ihre Geschwister gehen nicht zur Schule, sie haben keine Geburtsurkunden, und ein Arzt wird selbst bei fürchterlichsten Verletzungen nicht gerufen. Und die kommen häufig vor, denn die Kinder müssen bei der schweren Arbeit auf Vaters Schrottplatz helfen, um über die Runden zu kommen. Taras Mutter, die einzige Hebamme in der Gegend, heilt die Wunden mit ihren Kräutern. Nichts ist dieser Welt ferner als Bildung. Und doch findet Tara die Kraft, sich auf die Aufnahmeprüfung fürs College vorzubereiten, auch wenn sie quasi bei null anfangen muss ... Wie Tara Westover sich aus dieser Welt befreit, überhaupt erst einmal ein Bewusstsein von sich selbst entwickelt, um den schmerzhaften Abnabelungsprozess von ihrer Familie bewältigen zu können, das beschreibt sie in diesem ergreifenden und wunderbar poetischen Buch. » Befreit wirft ein Licht auf einen Teil unseres Landes, den wir zu oft übersehen. Tara Westovers eindringliche Erzählung — davon, einen Platz für sich selbst in der Welt zu finden, ohne die Verbindung zu ihrer Familie und ihrer geliebten Heimat zu verlieren — verdient es, weithin gelesen zu werden.« J.D. Vance Autor der »Hillbilly-Elegie«

Red Rising - Tag der Entscheidung

Roman

Author: Pierce Brown

Publisher: Heyne Verlag

ISBN: 3641147433

Category: Fiction

Page: 656

View: 7069

Das fulminante Finale der New York Times-Bestsellertrilogie Um eine unmenschliche und grausame Gesellschaft zu stürzen, ist der Minenarbeiter Darrow selbst zum Goldenen, zum Mitglied der verhassten Oberschicht, geworden. Doch jetzt wurde sein Geheimnis entdeckt und er schwebt in tödlicher Gefahr. Wenn er sein Ziel erreichen will, muss er alles riskieren.

Behavioral Genetics of the Fly (Drosophila Melanogaster)

Author: Josh Dubnau

Publisher: Cambridge University Press

ISBN: 1139952196

Category: Science

Page: N.A

View: 3048

The common fruit fly - Drosophila melanogaster - has been the subject of genetics research since the early twentieth century. The complete genomic sequence of Drosophila was published in 2000 and it is still the model organism par excellence for the experimental study of biological phenomena and processes. It is also by far the best model for studying gene function in mammals, including humans. Presenting state-of-the-art studies on the behaviour of Drosophila, this volume discusses normal and pathological models of neurobehavioral disorders and encompasses the specialised methods that have been used, from anatomical, histological, immunohistological and neurophysiological to genomic, genetic and behavioural assays. A comprehensive and thorough reference, this volume is a valuable resource for students and researchers alike across several disciplines of life sciences, including behavioral genetics, neurogenetics, behavioral neuroscience, molecular biology, evolutionary biology and population biology.

Color Atlas of Genetics

Author: Eberhard Passarge

Publisher: Thieme Medical Pub

ISBN: N.A

Category: Medical

Page: 411

View: 1613

Using visual presentation as a new approach to teaching, this color atlas displays the principles of genetics in 174 carefully designed color plates. A section of fundamentals covers molecular genetics, the structure and function of genes, chromosomes, and other basics. A section on genetics and medicine emphasizes the increasing role of genetics in the understanding of normal and abnormal biological functions, with many examples of human diseases. Other sections present the basic organization of genome in bacteria and higher organisms as a science in its own right, and the development of genetics. Definitions of genetic terms, maps of human genetic diseases, and references are included. This book is addressed to students of premedical and medical science, professionals in the health sciences, biologists, and other individuals wishing to obtain an overview of this important biomedical field.

The Art of Genes : How Organisms Make Themselves

How Organisms Make Themselves

Author: Enrico Coen

Publisher: Oxford University Press, UK

ISBN: 0191587672

Category: Science

Page: 396

View: 3452

How is a fertilized egg able to turn itself into an adult? Through a highly original synthesis of science and art, this book vividly describes the recent revolution in our understanding of how plants and animals develop, and the fresh insights this gives us into the nature of evolution and human creativity. - ;How is a tiny fertilised egg able to turn itself into a human being? How can an acorn transform itself into an oak tree? Through a highly original synthesis of science and art, this book vividly describes the recent revolution in our understanding of how plants and animals develop. Drawing on a wide range of material -- from flowers growing petals instead of sex organs, and flies that develop an extra pair of wings, to works by Leonardo and Magritte -- it explains the language and meaning of genes, in an entertaining way that is both accurate and accessible to the general reader. It shows how an organism develops through an interactive dialogue in which there is no clear separation between plan and execution, much as an artist might paint a picture. By explaining how this process has arisen, the book arrives at fresh and exciting insights into the nature of evolution, development and human creativity. -

The Handbook of Plant Genome Mapping

Genetic and Physical Mapping

Author: Khalid Meksem,Guenter Kahl

Publisher: John Wiley & Sons

ISBN: 352760443X

Category: Science

Page: 402

View: 3532

While the complete sequencing of the genomes of model organisms such as a multitude of bacteria and archaea, the yeast Saccharomyces cerevisiae, the worm Caenorhabditis elegans, the fly Drosophila melanogaster, and the mouse and human genomes have received much public attention, the deciphering of plant genomeswas greatly lagging behind. Up to now, only two plant genomes, one of the model plant Arabidopsis thaliana and one of the crop species rice (Oryza sativa) have been sequenced, though a series of other crop genome sequencing projects are underway. Notwithstanding this public bias towards genomics of animals and humans, it is nevertheless of great importance for basic and applied sciences and industries in such diverse fields as agriculture, breeding in particular, evolutionary genetics, biotechnology, and food science to know the composition of crop plant genomes in detail. It is equally crucial for a deeper understanding of the molecular basis of biodiversity and synteny. The Handbook of Genome Mapping: Genetic and Physical Mapping is the first book on the market to cover these hot topics in considerable detail, and is set apart by its combination of genetic and physical mapping. Throughout, each chapter begins with an easy-to-read introduction, also making the book the first reference designed for non-specialists and newcomers, too. In addition to being an outstanding bench work reference, the book is an excellent textbook for learning and teaching genomics, in particular for courses on genome mapping. It also serves as an up-to-date guide for seasoned researchers involved in the genetic and physical mapping of genomes, especially plant genomes.

Gene Expression at the Beginning of Animal Development

Author: Melvin L. DePamphilis

Publisher: Elsevier

ISBN: 9780444510488

Category: Medical

Page: 280

View: 6441

The beginning of life may be a miracle to some, and a mystery to others, but it is certainly one of the most exciting and perhaps controversial fields of scientific investigation in the 21st century. Among the metazoa, life begins when an egg is fertilized by a sperm. The sperm provides a genetic blueprint from the father and perhaps some critical proteins. The egg provides a genetic blueprint from the mother together with a large reservoir of mRNAs and proteins that are required for DNA replication, cell division and the onset of zygotic gene expression. All of the thousands of genes in these two mature gametes are transcriptionally silent and remain so until fertilization. This work focuses on three biological systems, providing the reader with a clear understanding of the current state of affairs, and the ability to identify common principles as well as critical differences that are responsible for beginning the process of animal development. The essays presented will be of practical value to all those who are interested in improving fertilization in vitro, in designing novel methods of contraception, in developing preimplantation genetic diagnosis for various diseases, in cloning animals by transplanting nuclei from adult cells to an enucleated egg, and in the application of embryonic stem cells to curing genetic diseases or replacing damaged tissues. But above all, this volume is offered to those who simply have an insatiable curiosity about life and its beginnings.