Principles of Drug Action

The Basis of Pharmacology

Author: William B. Pratt,Palmer Taylor

Publisher: N.A


Category: Medical

Page: 836

View: 2026

This new edition of Principles of Drug Action is a complete revision of a very-successful graduate-level pharmacology text previously authored by Avram Goldstein, Lewis Aronow and Sumner Kalman. Features: * Thorough survey of the many advances since the previous edition, plus a substantially expanded review of immunopharmacology * Covers basic principles of how drugs affect biological organisms * Explains the principles which govern drug action, absorption, metabolism, and distribution * Provides a solid grounding in modern biochemistry, molecular biology and genetics * Organized around systematic principles rather than drug families or drug effects

General and Molecular Pharmacology

Principles of Drug Action

Author: Francesco Clementi,Guido Fumagalli

Publisher: John Wiley & Sons

ISBN: 111876868X

Category: Medical

Page: 786

View: 5653

With a focus on functional relationships between drugs and theirtargets, this book covers basic and general pharmacology, from acellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis forproper clinical use- without neglecting clinical application,toxicology and pharmacokinetics. • Covers cell and molecular pharmacology,bringing together current research on regulation of drug targets,at a level appropriate for advanced undergrad and graduatestudents • Discusses the relevance ofpharmacokinetics and drug development for the clinical applicationof drugs • Presents material from the perspective ofdrug targets and interaction, the theoretical basis of drug actionanalysis, and drug properties • Focuses on structure-functionrelationships of drug targets – informing about theirbiochemical and physiologic functions and experimental and clinicalpathways for drug discovery and development • Has a companion website that offers ahost of resources: short additional chapters about methodology,topics at the forefront of research, all figures and tables fromthe book, and Power Point slides

Smith and Williams' Introduction to the Principles of Drug Design and Action

Author: H. John Smith,Hywel Williams

Publisher: CRC Press

ISBN: 9780203304150

Category: Medical

Page: 720

View: 8671

Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.


Drug Actions and Reactions

Author: Carol T. Walsh,Rochelle D. Schwartz-Bloom

Publisher: CRC Press

ISBN: 9780203005798

Category: Medical

Page: 561

View: 4390

Completely revised and updated, this is the seventh edition of Levine's classic pharmacology textbook. Known for it's thorough coverage and intelligent organization, the book covers the basic principles of pharmacological interactions on the human body in a way that is useful for both undergraduate and graduate students. Beginning with historical perspectives, nomenclature and definitions, the topics broaden to include sites and mechanisms of drug actions and travel to sites of action, as well as termination and elimination. The book also includes drug response and time-response relationships, response variability, drug toxicity, drug abuse, drug dependence, and more.

Introduction to the Principles of Drug Design

Author: H. J. Smith,Hywel Williams

Publisher: Elsevier

ISBN: 1483183505

Category: Medical

Page: 306

View: 6131

Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.

Stereochemical Aspects of Drug Action and Disposition

Author: Michel Eichelbaum,Bernard Testa,Andrew Somogyi

Publisher: Springer Verlag


Category: Medical

Page: 442

View: 8243

This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.

Basic Pharmacology

Understanding Drug Actions and Reactions

Author: Maria A. Hernandez, Ph.D.,Appu Rathinavelu, Ph.D.

Publisher: CRC Press

ISBN: 9781587161605

Category: Medical

Page: 392

View: 8742

Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.

Anesthetic Pharmacology

Basic Principles and Clinical Practice

Author: Alex S. Evers,Mervyn Maze,Evan D. Kharasch

Publisher: Cambridge University Press

ISBN: 1139497022

Category: Medical

Page: N.A

View: 7055

In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.

Drug Actions

Basic Principles and Theraputic Aspects

Author: Mutschler,Hartmut Derendorf

Publisher: CRC Press

ISBN: 9780849377747

Category: Medical

Page: 799

View: 9435

The most highly acclaimed pharmacology and toxicology text/reference used in Europe is now available in English. This excellent translation of Mutschler's Arzneimittelwirkungen combines a clear, informative narrative with 255 figures, 261 diagrams, and 198 tables to appeal to both new students and experts in pharmacy, pharmacology, and therapeutics. Drug structure and activity relationships are emphasized as an important dimension that is sometimes lacking in other pharmacology texts. Drug Actions is organized into three major sections covering general drug action and dosing principles, specific drug therapeutics, and toxicology. The first section provides an integrated overview of basic principles in pharmacology with chapters addressing pharmacokinetics, pharmacodynamics, drug side effects, drug interactions, chronopharmacology, rational and irrational drug combinations as well as drug developments and drug trials. The second section systematically describes specific drug actions with pharmacology, clinical indications, standard doses side effects, and contraindications described for each approved drug category. The third section addresses toxicology where specific drug toxicities are identified and treatment options for accidental and drug associated poisoning are presented. Topics covered include environmental, occupational, and nutritional exposure to toxins.

The Organic Chemistry of Drug Design and Drug Action

Author: Richard B. Silverman

Publisher: Elsevier

ISBN: 0080571239

Category: Science

Page: 422

View: 1025

This is a new approach to the teaching of medicinal chemistry. The knowledge of the physical organic chemical basis of drug design and drug action allows the reader to extrapolate to the many related classes of drugs described in standard medicinal chemistry texts. Students gain a solid foundation to base future research endeavors upon: drugs not yet developed are thus covered! n Emphasizes the use of the principles of physical organic chemistry as a basis for drug design n Discusses organic reaction mechanisms of clinically important drugs with mechanistic schemes n Uses figures and literature references extensively throughout n This text is not merely a "compilation of drugs and uses," but features selected drugs as examples of the organic chemical basis for any and all drug design applications

Molecular Mechanisms Of Drug Action

Author: Christopher J. Coulson

Publisher: CRC Press

ISBN: 1482295210

Category: Medical

Page: 300

View: 3043

In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.

Principles of Pharmacology for Athletic Trainers

Author: Joel E. Houglum,Gary L. Harrelson,Deidre Leaver-Dunn

Publisher: SLACK Incorporated

ISBN: 9781556425943

Category: Medical

Page: 422

View: 8503

Principles of Pharmacology for Athletic Trainers is designed to help athletic training students understand the basic principles of pharmacology, as well as the broad classification of drugs. Drs. Joel Houglum, Gary Harrelson, and Deidre Leaver-Dunn have created a user-friendly format to help students meet the pharmacology domain outlined in the NATA Competencies in Athletic Training. Over 100 helpful figures and tables help to summarize the information presented and provide clinical examples. Principles of Pharmacology for Athletic Trainers begins by detailing the principles of drug action, administering and dispensing drugs, using drug references, medication adverse effects, therapy considerations, and classification of drugs. The pharmacological actions of eight categories of drugs including antibiotics, anti-inflammatory medications, and gastrointestinal medications are examined in the next section. Each drug-specific chapter profiles the biological effects, indications, adverse effects, and the drugs' impact on exercise or how exercise can impact the distribution and availability of drugs. In providing a complete and up-to-date summary of pharmacology, Principles of Pharmacology for Athletic Trainers concludes with an overview of performance enhancing drugs and an in-depth analysis of drug testing. Principles of Pharmacology for Athletic Trainers is a unique resource that not only simplifies the broad range of principles and classification of drugs; it also provides specific application information for the athletic trainer. Features Evaluates the role of the athletic trainer within each drug category. Includes examples of the clinical use and effects of drugs from specific pharmacological categories. Advanced organizers are used at the beginning of each chapter to present an overview of the chapter topics. These concept maps or flow diagrams help the visual learner to better understand concepts and the connection between concepts covered in each chapter. Text boxes review important concepts already presented. Tables provide examples of drugs by category.


Author: Gary C. Rosenfeld,David S. Loose

Publisher: Lippincott Williams & Wilkins

ISBN: 9780781780742

Category: Medical

Page: 372

View: 6398

This concise review of medical pharmacology is designed for medical students, dental students, and others in the health care professions. It is intended primarily to help students prepare for licensing examinations such as the USMLE Step 1 or similar examinations. Each chapter presents specific drugs and discusses their general properties, mechanism of action, pharmacologic effects, therapeutic uses, and adverse effects. Drug lists and two-color tables and figures summarize essential drug information in all chapters. Clinically oriented USMLE-style review questions and answers with explanations follow each chapter. A comprehensive examination consisting of USMLE-style questions appears at the end of the book.

Principles of Pharmacology

The Pathophysiologic Basis of Drug Therapy

Author: David E. Golan,Armen H. Tashjian,Ehrin J. Armstrong

Publisher: Lippincott Williams & Wilkins

ISBN: 1608312704

Category: Medical

Page: 954

View: 2276

Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty

Kinetics of Enzyme Action

Essential Principles for Drug Hunters

Author: Ross L. Stein

Publisher: John Wiley & Sons

ISBN: 9781118084403

Category: Science

Page: 320

View: 6986

Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.


Drug Actions and Reactions, Seventh Edition

Author: R.R. Levine,C.T. Walsh,Rochelle D. Schwartz-Bloom

Publisher: CRC Press

ISBN: 9781850704973

Category: Medical

Page: 592

View: 6044

This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.

Smith and Williams' Introduction to the Principles of Drug Design and Action, Third Edition

Author: H. John Smith,Hywel Williams

Publisher: CRC Press

ISBN: 0203496671

Category: Medical

Page: 568

View: 8318

The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials

Medical Pharmacology at a Glance

Author: Michael J. Neal

Publisher: John Wiley & Sons

ISBN: 0470657898

Category: Medical

Page: 120

View: 3202

Widely recognised as the best starting point for pharmacology study, the internationally best-selling Medical Pharmacology at a Glance is an ideal companion for all students of the health sciences. Key principles are supported by coloured schematic diagrams - invaluable as both an introduction to medical pharmacology, and revision in the run-up to pharmacology exams. Revised and thoroughly updated throughout, and reflecting changes to the content and assessment methods used by medical schools, Medical Pharmacology at a Glance: Introduces the basic principles of drug action, interaction, absorption and excretion Bases chapters on diseases and syndromes, for clinically-focused learning Includes references to the pathophysiology of disease, to aid understanding of drug choice and action Indicates the therapeutics of choice for specific disorders and conditions Features cross references between discussion of drug classes and diseases Includes self-assessment cases studies with full answers, for revision and review Features a new chapter on immunosuppressants and antirheumatoid drugs Now includes a brand new companion website, with cases and fully downloadable flashcards, at