This new edition of Principles of Drug Action is a complete revision of a very-successful graduate-level pharmacology text previously authored by Avram Goldstein, Lewis Aronow and Sumner Kalman. Features: * Thorough survey of the many advances since the previous edition, plus a substantially expanded review of immunopharmacology * Covers basic principles of how drugs affect biological organisms * Explains the principles which govern drug action, absorption, metabolism, and distribution * Provides a solid grounding in modern biochemistry, molecular biology and genetics * Organized around systematic principles rather than drug families or drug effects
The Basis of Pharmacology
Author: William B. Pratt,Palmer Taylor
With a focus on functional relationships between drugs and theirtargets, this book covers basic and general pharmacology, from acellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis forproper clinical use- without neglecting clinical application,toxicology and pharmacokinetics. • Covers cell and molecular pharmacology,bringing together current research on regulation of drug targets,at a level appropriate for advanced undergrad and graduatestudents • Discusses the relevance ofpharmacokinetics and drug development for the clinical applicationof drugs • Presents material from the perspective ofdrug targets and interaction, the theoretical basis of drug actionanalysis, and drug properties • Focuses on structure-functionrelationships of drug targets – informing about theirbiochemical and physiologic functions and experimental and clinicalpathways for drug discovery and development • Has a companion website that offers ahost of resources: short additional chapters about methodology,topics at the forefront of research, all figures and tables fromthe book, and Power Point slides
Principles of Drug Action
Author: Francesco Clementi,Guido Fumagalli
Publisher: John Wiley & Sons
the basis of pharmacology
Author: Avram Goldstein,Lewis Aronow,Sumner M. Kalman
Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.
Author: H. John Smith,Hywel Williams
Publisher: CRC Press
The most highly acclaimed pharmacology and toxicology text/reference used in Europe is now available in English. This excellent translation of Mutschler's Arzneimittelwirkungen combines a clear, informative narrative with 255 figures, 261 diagrams, and 198 tables to appeal to both new students and experts in pharmacy, pharmacology, and therapeutics. Drug structure and activity relationships are emphasized as an important dimension that is sometimes lacking in other pharmacology texts. Drug Actions is organized into three major sections covering general drug action and dosing principles, specific drug therapeutics, and toxicology. The first section provides an integrated overview of basic principles in pharmacology with chapters addressing pharmacokinetics, pharmacodynamics, drug side effects, drug interactions, chronopharmacology, rational and irrational drug combinations as well as drug developments and drug trials. The second section systematically describes specific drug actions with pharmacology, clinical indications, standard doses side effects, and contraindications described for each approved drug category. The third section addresses toxicology where specific drug toxicities are identified and treatment options for accidental and drug associated poisoning are presented. Topics covered include environmental, occupational, and nutritional exposure to toxins.
Basic Principles and Theraputic Aspects
Author: Mutschler,Hartmut Derendorf
Publisher: CRC Press
Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.
Understanding Drug Actions and Reactions
Author: Maria A. Hernandez, Ph.D.,Appu Rathinavelu, Ph.D.
Publisher: CRC Press
Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.
Author: H. J. Smith,Hywel Williams
introduction to the principles of drug action
Author: John A. Bevan,Jeremy H. Thompson
In this book the targets of drug action are the central focus - whether they be enzymes in a pathway or membrane-bound receptors and ion channels. This approach distinguishes the book from others in the f ield which consider the subject mainly in terms of disease.; The introductory chapter is concerned with the basic principles that cover enzyme inhibition and receptor binding by drugs. The next seven chapters deal with drugs that modulate biochemical pathways, both of synthesis and breakdown, while the last four chapters are concerned with organizational structures of the cell.; The book brings together the state of knowledge with respect to drug action and emphasizes mechanistic aspects of drug action. It encompasses the modes of action of drugs for infectious disease and those for endogenous conditions. There is a listing of reviews and essay questions are provided for each chapter.
Author: Christopher J. Coulson
Publisher: CRC Press
This concise review of medical pharmacology is designed for medical students, dental students, and others in the health care professions. It is intended primarily to help students prepare for licensing examinations such as the USMLE Step 1 or similar examinations. Each chapter presents specific drugs and discusses their general properties, mechanism of action, pharmacologic effects, therapeutic uses, and adverse effects. Drug lists and two-color tables and figures summarize essential drug information in all chapters. Clinically oriented USMLE-style review questions and answers with explanations follow each chapter. A comprehensive examination consisting of USMLE-style questions appears at the end of the book.
Author: Gary C. Rosenfeld,David S. Loose
Publisher: Lippincott Williams & Wilkins
The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates
Author: Richard B. Silverman,Mark W. Holladay
Publisher: Academic Press
Now in its third edition, Principles of Pharmacology presents content in a conceptual framework that maximizes understanding and retention and minimizes rote memorization. It takes students "beyond the disease" and deep into physiologic, biochemical, and pathophysiologic systems where drugs activate or inhibit these systems by interacting with molecular and cellular targets. This unique approach ensures understanding of the mechanisms of drug actions on the body, and ultimately, in treating the human patient. Ideal for introductory pharmacology courses that emphasize critical thinking, molecular understanding, systems-based integration, and clinical preparation, the text: Features chapter-opening clinical cases and questions to establish a context for the discussion and the answers that follow Presents signature drug summary tables, updated and organized by mechanism of action, with information on clinical applications, adverse effects, contraindications, and therapeutic considerations Incorporates NEW full-color illustrations throughout, suiting the needs of visual learners and more effectively presenting concepts covered in the narrative Integrates timely content, including recently approved drugs as well as current research on drug mechanisms of action Delivers course and review material appropriate for students through a uniquely collaborative authorship consisting of medical students, residents, and faculty
The Pathophysiologic Basis of Drug Therapy
Author: David E. Golan,Armen H. Tashjian,Ehrin J. Armstrong
Publisher: Lippincott Williams & Wilkins
This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.
Drug Actions and Reactions, Seventh Edition
Author: R.R. Levine,C.T. Walsh,Rochelle D. Schwartz-Bloom
Publisher: CRC Press
Principles of Pharmacology for Athletic Trainers is designed to help athletic training students understand the basic principles of pharmacology, as well as the broad classification of drugs. Drs. Joel Houglum, Gary Harrelson, and Deidre Leaver-Dunn have created a user-friendly format to help students meet the pharmacology domain outlined in the NATA Competencies in Athletic Training. Over 100 helpful figures and tables help to summarize the information presented and provide clinical examples. Principles of Pharmacology for Athletic Trainers begins by detailing the principles of drug action, administering and dispensing drugs, using drug references, medication adverse effects, therapy considerations, and classification of drugs. The pharmacological actions of eight categories of drugs including antibiotics, anti-inflammatory medications, and gastrointestinal medications are examined in the next section. Each drug-specific chapter profiles the biological effects, indications, adverse effects, and the drugs' impact on exercise or how exercise can impact the distribution and availability of drugs. In providing a complete and up-to-date summary of pharmacology, Principles of Pharmacology for Athletic Trainers concludes with an overview of performance enhancing drugs and an in-depth analysis of drug testing. Principles of Pharmacology for Athletic Trainers is a unique resource that not only simplifies the broad range of principles and classification of drugs; it also provides specific application information for the athletic trainer. Features Evaluates the role of the athletic trainer within each drug category. Includes examples of the clinical use and effects of drugs from specific pharmacological categories. Advanced organizers are used at the beginning of each chapter to present an overview of the chapter topics. These concept maps or flow diagrams help the visual learner to better understand concepts and the connection between concepts covered in each chapter. Text boxes review important concepts already presented. Tables provide examples of drugs by category.
Author: Joel E. Houglum,Gary L. Harrelson,Deidre Leaver-Dunn
Publisher: SLACK Incorporated
Apple, Audi, Braun oder Samsung machen es vor: Gutes Design ist heute eine kritische Voraussetzung für erfolgreiche Produkte. Dieser Klassiker beschreibt die fundamentalen Prinzipien, um Dinge des täglichen Gebrauchs umzuwandeln in unterhaltsame und zufriedenstellende Produkte. Don Norman fordert ein Zusammenspiel von Mensch und Technologie mit dem Ziel, dass Designer und Produktentwickler die Bedürfnisse, Fähigkeiten und Handlungsweisen der Nutzer in den Vordergrund stellen und Designs an diesen angepasst werden. The Design of Everyday Things ist eine informative und spannende Einführung für Designer, Marketer, Produktentwickler und für alle an gutem Design interessierten Menschen. Zum Autor Don Norman ist emeritierter Professor für Kognitionswissenschaften. Er lehrte an der University of California in San Diego und der Northwest University in Illinois. Mitte der Neunzigerjahre leitete Don Norman die Advanced Technology Group bei Apple. Dort prägte er den Begriff der User Experience, um über die reine Benutzbarkeit hinaus eine ganzheitliche Erfahrung der Anwender im Umgang mit Technik in den Vordergrund zu stellen. Norman ist Mitbegründer der Beratungsfirma Nielsen Norman Group und hat unter anderem Autohersteller von BMW bis Toyota beraten. „Keiner kommt an Don Norman vorbei, wenn es um Fragen zu einem Design geht, das sich am Menschen orientiert.“ Brand Eins 7/2013 „Design ist einer der wichtigsten Wettbewerbsvorteile. Dieses Buch macht Spaß zu lesen und ist von größter Bedeutung.” Tom Peters, Co-Autor von „Auf der Suche nach Spitzenleistungen“
Psychologie und Design der alltäglichen Dinge
Author: Norman Don
Category: Business & Economics
The third edition of this popular textbook builds on the excellent foundations laid down by the earlier editions. It provides a thorough introduction to the principles of rational drug design, adopting a 'from the bench to the market place' approach. As knowledge of biological systems has expanded and the number of techniques available for exploring and visualizing their components has increased, it has become possible to design drugs specifically for a given target. This unique insight has revolutionized the process of drug development for specific disease states, and in this textbook both novel and established approaches are incorporated. The introductory text explains the principles of drug design using real examples. These illustrate the discovery of 'lead' compounds and their manipulation to produce non-toxic drug candidates that will be successfully metabolized to interact with target receptors in a predicted fashion. In addition to fully updating the contents of the previous edition, the Editor has included important new sections on the pharmacological consequences of drug chirality, agonists and antagonists of neurotransmitters, and the process involved in proceeding from program sanction to clinical trials
Author: H. John Smith,Hywel Williams
Publisher: CRC Press
Written primarily for students of medicine, pharmacy, and pharmacology, this introductory book provides a concise summary of the principles that underlie the science of pharmacology. It presents the basic concepts required for understanding the use, mechanisms of action, toxicity and side effects, and therapeutic application of drugs in man. Thus the book may also be of interest to medical practitioners and to biological and medical scientists. Among topics covered are the sources of drugs, the way they are administered and dealt with in the body, as well as concepts about the nature of their actions. The last include their chemical interactions with components of cells and the manner in which these lead to therapeutically desirable as well as undesirable and even toxic effects. In addition, clinically related subjects, such as drug interactions, teratogenic and carcinogenic effects are discussed. The development and testing of new drugs are also described. For easy reference, at the back of the book there is a glossary of drugs named in the text.
A Primer on Drug Action
Author: Peter J. Bentley
Publisher: Cambridge University Press
This revised second edition covers the pharmacologic principles underlying the individualization of patient therapy and contemporary drug development, focusing on the fundamentals that underlie the clinical use and contemporary development of pharmaceuticals. Authors drawn from academia, the pharmaceutical industry and government agencies cover the spectrum of material, including pharmacokinetic practice questions, covered by the basic science section of the certifying examination offered by the American Board of Clinical Pharmacology. This unique reference is recommended by the Board as a study text and includes modules on drug discovery and development to assist students as well as practicing pharmacologists. * Unique breadth of coverage ranging from drug discovery and development to individualization and quality assessment of drug therapy. * Unusual cohesive of presentation that stems from author participation in an ongoing popular NIH course. * Instructive linkage of pharmacokinetic theory and applications with provision of sample problems for self-study. * Wide-ranging perspective of authors drawn from the ranks of Federal agencies, academia and the pharmaceutical industry. * Expanded coverage of pharmacogenetics * Expanded coverage of drug transporters and their role in interactions * Inclusion of new material on enzyme induction mechanisms in chapters on drug metabolism and drug interactions * A new chapter on drug discovery that focuses on oncologic agents * Inclusion of therapeutic antibodies in chapter on biotechnology products
Author: Arthur J. Atkinson, Jr.,Darrell R. Abernethy,Charles E. Daniels,Robert Dedrick,Sanford P. Markey
Completely revised and updated, this is the seventh edition of Levine's classic pharmacology textbook. Known for it's thorough coverage and intelligent organization, the book covers the basic principles of pharmacological interactions on the human body in a way that is useful for both undergraduate and graduate students. Beginning with historical perspectives, nomenclature and definitions, the topics broaden to include sites and mechanisms of drug actions and travel to sites of action, as well as termination and elimination. The book also includes drug response and time-response relationships, response variability, drug toxicity, drug abuse, drug dependence, and more.
Drug Actions and Reactions
Author: Carol T. Walsh,Rochelle D. Schwartz-Bloom
Publisher: CRC Press