This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards. Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching. New to the Fourth Edition: reorganized sections that cover basic principles followed by sections on different types of toxicity extensive use of examples throughout and numerous explanatory diagrams new material on risk assessment, export systems, oxidative stress, Thalidomide, Tamoxifen and asbestos proliferators, domoic acid, bone marrow (benzene), heart (adriamycin), blood (primaquine), biomarkers, cytochrome P450 and other enzymes, receptor mediated effects, endocrine disruption, ethanol, botox, arsenic, and more questions with answers for each chapter for review and self-checking expanded and updated chapter bibliographies
Author: John A. Timbrell
Publisher: Informa Health Care
An essential resource for graduate students, academic and industrial toxicologists, and environmental health scientists and professionals Over the course of thirty years and three editions, Introduction to Biochemical Toxicology has been an important source for coverage of the ongoing quest to define the biochemical, cellular, and molecular events induced by toxicants at the cellular and organismic levels. Now, as the principles and methods of molecular and cellular biology as well as genomic sciences play an ever increasing role in mechanistic toxicology, significant changes have been made to the book, resulting in this important new edition-now titled Molecular and Biochemical Toxicology, Fourth Edition. Much more than an introductory text, this crucial new edition has been completely revised to provide timely and thorough coverage of the underlying biochemical, molecular, and cellular mechanisms through which toxicants produce their adverse effects. Toxicological issues are covered from the molecule to the cell to the organ level. Complex methods used in toxicology are also described in a straightforward, easy-to-understand style. Additional features of this new edition include: New chapters that explore the interface between toxicology and genomic sciences, including: bioinformatics, proteomics, metabolomics, and toxicogenomics Increased emphasis on structure, mechanism, and regulation of xenobiotic metabolizing enzymes, toxicogenetics, and xenobiotic transporters Additional new chapters on: molecular epidemiology and genetic susceptibility, DNA damage and mutagenesis, DNA repair, mechanisms of cell death, mitochondrial dysfunction, metals, reproductive toxicology, developmental toxicology, and reactive oxygen/metabolites and toxicity Molecular and Biochemical Toxicology, Fourth Edition guides graduate students, toxicologists, and environmental health professionals through the principles of molecular and biochemical toxicology and the complex mechanisms of toxicity. Whether it's used in the classroom or in industry, research, or academia, this book is essential for anyone interested in understanding the molecular mechanisms through which toxicants produce adverse effects.
Author: Robert C. Smart,Ernest Hodgson
Publisher: John Wiley & Sons
Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools for assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists.
Author: Beate Escher,Frederic Leusch
Publisher: IWA Publishing
Cutting across traditional subject boundaries, Principles of Ecotoxicology, Fourth Edition gives readers an integrated view of ecotoxicology, from molecules to ecosystems. This new edition of a bestselling textbook continues to emphasize principles rather than practice, providing the interdisciplinary perspective and grounding required for research. Organized into three sections, the book first describes the molecular structures, properties, and environmental fate of pollutants. It then deals with the effects of pollutants on living organisms at the molecular, cellular, and individual levels. Moving into population biology and population genetics, the third part of the book addresses a question of great interest to ecologists: What effects do pollutants have at the levels of population, community, and the whole ecosystem? The book also looks at how ecotoxicology is used in the biomonitoring of environmental pollution, the investigation of pollution problems, the conducting of field trials, the study of the development of resistance, and the growing area of environmental risk assessments. Throughout, examples and case studies illustrate the principles. This updated fourth edition includes new material on nanoparticle pollution, bioaccumulation, biomarkers, and chemical warfare in nature, as well as a new chapter on the future directions of ecotoxicology. A concise textbook that will also appeal to practicing ecotoxicologists, it provides a solid basis for understanding what happens to chemicals in the real world, where they go, how they ultimately degrade, and how they affect the individuals and populations that encounter them. What’s New in This Edition Revised and updated material throughout A chapter on future directions of ecotoxicology New material on nanoparticle pollution and chemical warfare in nature Expanded coverage of bioaccumulation, biomarkers, and risk assessment for affected populations More case studies, many from the United States Discussion of neurotoxic and behavioral effects of pollutants Recent research on the decline of vultures and effects of neonicotinoids on bees Organic Pollutants: An Ecotoxicological Perspective, Second Edition (CRC Press, 2008), a companion volume to this book, covers the mechanistic aspects of ecotoxicology in more depth.
Author: C.H. Walker,R.M. Sibly,S.P. Hopkin,D.B. Peakall
Publisher: CRC Press
Fundamentals of Environmental and Toxicological Chemistry: Sustainable Science, Fourth Edition covers university-level environmental chemistry, with toxicological chemistry integrated throughout the book. This new edition of a bestseller provides an updated text with an increased emphasis on sustainability and green chemistry. It is organized based on the five spheres of Earth’s environment: (1) the hydrosphere (water), (2) the atmosphere (air), (3) the geosphere (solid Earth), (4) the biosphere (life), and (5) the anthrosphere (the part of the environment made and used by humans). The first chapter defines environmental chemistry and each of the five environmental spheres. The second chapter presents the basics of toxicological chemistry and its relationship to environmental chemistry. Subsequent chapters are grouped by sphere, beginning with the hydrosphere and its environmental chemistry, water pollution, sustainability, and water as nature’s most renewable resource. Chapters then describe the atmosphere, its structure and importance for protecting life on Earth, air pollutants, and the sustainability of atmospheric quality. The author explains the nature of the geosphere and discusses soil for growing food as well as geosphere sustainability. He also describes the biosphere and its sustainability. The final sphere described is the anthrosphere. The text explains human influence on the environment, including climate, pollution in and by the anthrosphere, and means of sustaining this sphere. It also discusses renewable, nonpolluting energy and introduces workplace monitoring. For readers needing additional basic chemistry background, the book includes two chapters on general chemistry and organic chemistry. This updated edition includes three new chapters, new examples and figures, and many new homework problems.
Sustainable Science, Fourth Edition
Author: Stanley E. Manahan
Publisher: CRC Press
Die Physiologie des Menschen für Studierende der Medizin und Ärzte
Author: William F. Ganong
Auf Einladung der Deutschen Forschungsgemeinschaft (DFG) fand am 9. und 10. März 2000 ein Rundgespräch über heutige und künftige Möglichkeiten des Biomonitoring in Arbeits- und Umweltmedizin statt. Das Biomonitoring hat nicht zuletzt durch die unmittelbare Umsetzung der Arbeitsergebnisse der Senatskommission zur Prüfung gesundheitsschädlicher Arbeitsstoffe in geltendes Recht durch die deutsche Arbeitsschutzgesetzgebung in den letzten dreißig Jahren in Deutschland ein hohes Niveau erreicht. Das vorliegende Buch führt die Expertise verschiedener Fachdisziplinen von der Toxikologie, Arbeitsmedizin, Immunologie und Humangenetik bis hin zur Analytik und Epidemiologie zusammen. Hierbei wird die diagnostische Aussagekraft von zytogenetischen Parametern sowie von biochemischen und biologischen Effektmarkern für die Prävention von schadstoffbedingter Erkrankungen ausführlich erörtert. Das geführte Rundgespräch hat somit einen ersten Gedankenaustausch ermöglicht, aus dem sich künftige Forschung entwickeln soll, um die führende Rolle Deutschlands auf diesem wichtigen und sich dynamisch entwickelnden Forschungsgebiet zu halten.
Heutige und Kunftige Moglichkeiten in der Arbeits- und Umweltmedizin
Author: Jurgen Angerer
Publisher: John Wiley & Sons
Completely revised and updated, Fundamentals of Ecotoxicology, Second Edition presents a treatment of ecotoxicology ranging from molecular to global perspectives. The authors focus first on lower levels of organization and then extend their discussion to include landscape, regional, and biospheric topics, imparting a perspective as broad as the the problems facing practicing professionals. See what's new in this edition: A comprehensive chapter on the nature, transport, and fate of major classes of contaminants in terrestrial, freshwater, and marine systems Side bars containing vignettes by leaders in the field let you benefit from the experience of diverse practitioners in the field An appendix covering European environmental regulations The authors detail key contaminants of concern, explore their fate and cycling in the biosphere, and discuss bioaccumulation and the effects of contaminants at increasing levels of ecological organization. They cover regulatory aspects of the field in separate chapters that address the technical issues of risk assessment and discuss key U.S. and European legislation in the appendices. Complete with study questions, a detailed glossary, and vignettes by various experts exploring special topics in ecotoxicology, Fundamentals of Ecotoxicology, Second Edition is an ideal introductory textbook for both undergraduate- and graduate-level courses, as well as a valuable reference for professionals.
Author: Michael C. Newman,Michael A. Unger
Publisher: CRC Press
Author: T. Haferlach,H. Begemann,J. Rastetter
This modern textbook stands out from other standard textbooks. The framework for the learning units is based on fundamental principles of inorganic chemistry, such as symmetry, coordination, and periodicity. Specific examples of chemical reactions are presented to exemplify and demonstrate these principles. Numerous new illustrations, a new layout, and large numbers of exercises following each chapter round out this new edition.
Prinzipien von Struktur und Reaktivität
Author: James Huheey,Ellen Keiter,Richard Keiter
Publisher: Walter de Gruyter GmbH & Co KG
5 Tage für innere Ruhe - Strukturiert und konzentriert bekommen Sie hier die prüfungsrelevante Innere Medizin in 5 Tagen. Für alle, die sich kurz vor knapp auf das "Hammerexamen" vorbereiten und während des PJs kaum Zeit haben ist dieses Buch "der Hammer". Die Inhalte sind nach ihrer Häufigkeit in den IMPP-Fragen gewichtet. So können Sie sicher sein, nicht stundenlang Exoten zu lernen, die dann doch nie geprüft werden. Die Texte sind stichpunktartig geschrieben, sinnvolle Tabellen und Hinweise auf Prüfungsfallen und Verwechslungsgefahren ergänzen die Fakten. Platz für eigene Notizen bietet die Randspalte, so können Sie auch ganz spezielle Inhalte für die mündliche Prüfung festhalten. Und natürlich können Sie die Lerneinheiten auch auf eine längere Zeit verteilen. Kürzer und kompakter geht es für die Prüfung nun wirklich nicht.
Author: Wolfram Karges,Sascha Al Dahouk
Handbook of the Toxicology of Metals is the standard reference work for physicians, toxicologists and engineers in the field of environmental and occupational health. This new edition is a comprehensive review of the effects on biological systems from metallic elements and their compounds. An entirely new structure and illustrations represent the vast array of advancements made since the last edition. Special emphasis has been placed on the toxic effects in humans with chapters on the diagnosis, treatment and prevention of metal poisoning. This up-to-date reference provides easy access to a broad range of basic toxicological data and also gives a general introduction to the toxicology of metallic compounds. * Covers up-to-date toxicological information on 31 metallic elements and their compounds, each in a separate chapter * New chapters on general chemistry, biological monitoring and biomarkers, essential metals, principles for prevention of the toxic effects of metals, and more
Author: Monica Nordberg,Gunnar F. Nordberg,Bruce A. Fowler,Lars Friberg
Im Leben eines Biologen und auch in dem eines Chemikers kommt irgendwann der Tag, an dem plötzlich die Biochemie vor der Tür steht oder gleich hineinpoltert. "Biochemie für Dummies" bereitet Sie auf diesen Tag vor oder hilft Ihnen, die Folgen zu verkraften. Von Zellstrukturen über Kohlenwasserstoffe, Aminosäuren und Proteine erklärt Ihnen das was Sie über Biochemie wissen müssen. So einfach wie möglich, so komplex wie nötig werden Sie hier in die Welt der Lipide, Vitamine und Hormone eingeführt und erfahren, was ATP jenseits des Tennisplatzes bedeutet.
Author: John W. Moore
Publisher: John Wiley & Sons
This book deals with the methods and scientific basis of inhalation toxicology. It describes devices and facilities needed to expose animals to inhaled particles and gases as well as approaches to estimating or measuring the fraction of the inhaled material that is retained in the respiratory tract. The book then reviews the evergrowing repertoire of techniques that can be used to measure the responses elicited by the exposure. Quantitative and qualitative anatomical, physiological, and biochemical strategies are discussed in detail. We believe that the toxicology of inhaled materials is an important and timely topic for several'reasons. During the past decade, morbidity and mortality attributable to cardiovascular disease have significantly decreased. Progress in combatting cancer, the second most important cause of death, has been slower, and lung cancer actually became the leading cause of death in men and the second leading cause of cancer death in women. In addition, the incidence of non-neo plastic respiratory diseases such as emphysema, fibrosis, and chronic bronchitis has increased the past decade. In the United States, the National Institutes of Health (NIH) has recently reported that chronic obstructive pulmonary disease affects nearly 10 miliion persons and accounts for 59,000 deaths yearly; indeed, it ranks as the fifth leading cause of death. Because the incidence is increasing, the NIH estimates that it may become the nation's fourth or even third leading cause of death by the year 2000.
General Principles of Inhalation Toxicology
Author: H.P. Witschi,J.D. Brain
Publisher: Springer Science & Business Media
Author: Trevor J. Franklin,George A. Snow
Category: Toxicological interactions