Practical Nuclear Magnetic Resonance Relaxation for Chemists

Author: Vladimir I. Bakhmutov

Publisher: John Wiley & Sons

ISBN: 9780470094471

Category: Science

Page: 216

View: 898

This book demonstrates how NMR relaxation can be applied for structural diagnostics of chemical compounds, recognition of weak intermolecular interactions, determinations of internuclear distances and lengths of chemical bonds when compounds under investigation can exist only in solutions. Written as a textbook for chemists, demanding little background in physics and NMR Its practical approach helps the reader to apply the techniques in the lab First book to teach NMR Relaxation techniques to chemists

Nuclear Magnetic Resonance Spectroscopy

An Introduction to Principles, Applications, and Experimental Methods

Author: Joseph B. Lambert,Eugene Mazzola,Clark D. Ridge

Publisher: Wiley

ISBN: 1119295238

Category: Science

Page: 480

View: 3686

Combines clear and concise discussions of key NMR concepts with succinct and illustrative examples Designed to cover a full course in Nuclear Magnetic Resonance (NMR) Spectroscopy, this text offers complete coverage of classic (one-dimensional) NMR as well as up-to-date coverage of two-dimensional NMR and other modern methods. It contains practical advice, theory, illustrated applications, and classroom-tested problems; looks at such important ideas as relaxation, NOEs, phase cycling, and processing parameters; and provides brief, yet fully comprehensible, examples. It also uniquely lists all of the general parameters for many experiments including mixing times, number of scans, relaxation times, and more. Nuclear Magnetic Resonance Spectroscopy: An Introduction to Principles, Applications, and Experimental Methods, 2nd Edition begins by introducing readers to NMR spectroscopy - an analytical technique used in modern chemistry, biochemistry, and biology that allows identification and characterization of organic, and some inorganic, compounds. It offers chapters covering: Experimental Methods; The Chemical Shift; The Coupling Constant; Further Topics in One-Dimensional NMR Spectroscopy; Two-Dimensional NMR Spectroscopy; Advanced Experimental Methods; and Structural Elucidation. Features classical analysis of chemical shifts and coupling constants for both protons and other nuclei, as well as modern multi‐pulse and multi-dimensional methods Contains experimental procedures and practical advice relative to the execution of NMR experiments Includes a chapter-long, worked-out problem that illustrates the application of nearly all current methods Offers appendices containing the theoretical basis of NMR, including the most modern approach that uses product operators and coherence-level diagrams By offering a balance between volumes aimed at NMR specialists and the structure-determination-only books that focus on synthetic organic chemists, Nuclear Magnetic Resonance Spectroscopy: An Introduction to Principles, Applications, and Experimental Methods, 2nd Edition is an excellent text for students and post-graduate students working in analytical and bio-sciences, as well as scientists who use NMR spectroscopy as a primary tool in their work.

Nuclear Magnetic Resonance

Author: Royal Society of Chemistry

Publisher: Royal Society of Chemistry

ISBN: 085404115X

Category: Medical

Page: 500

View: 2082

For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.

Nuclear Magnetic Resonance Spectroscopy

Author: Frank A. Bovey,Peter A. Mirau,H. S. Gutowsky

Publisher: Elsevier

ISBN: 0080916996

Category: Science

Page: 653

View: 4178

Nuclear Magnetic Resonance Spectroscopy, Second Edition focuses on two-dimensional nuclear magnetic resonance (NMR) spectroscopy, high resolution NMR of solids, water suppression, multiple quantum spectroscopy, and NMR imaging. The selection first takes a look at the fundamental principles and experimental methods. Discussions focus on the NMR phenomenon, dipolar broadening and spin-spin relaxation, nuclear electric quadrupole relaxation, saturation, magnetic shielding and chemical shift, magnetic field, transitions between the nuclear energy levels, and resolution and sensitivity considerations. The manuscript then ponders on chemical shift, coupling of nuclear spins, and nuclear relaxation and chemical rate processes. Topics include spin lattice relaxation, spin-spin relaxation, spin decoupling and associated techniques, and description and analysis of spin systems. The text examines two-dimensional NMR spectroscopy, macromolecules, and NMR of solids, including magic angle spinning, cross polarization, proton dipolar broadening, biopolymers, and chain motion in macromolecules. The selection is a valuable source of data for readers interested in nuclear magnetic resonance spectroscopy.

LC-NMR and Other Hyphenated NMR Techniques

Overview and Applications

Author: Maria V. Silva Elipe

Publisher: John Wiley & Sons

ISBN: 1118135385

Category: Science

Page: 256

View: 9964

This practical guide provides a basic overview of the pros and cons of NMR spectroscopy as both a hyphenated and non-hyphenated technique. The book begins with a description of basic NMR concepts for the structural elucidation of organic compounds and then details the historical development of NMR and hyphenated NMR in the structural elucidation world, followed by applications of hyphenated NMR as LC-NMR and LC-MS-NMR in industry and academia. It also contains updated information on the latest advancements and applications of LC-NMR in such areas as degradation products, drug metabolism, food analysis, and drug discovery. An essential resource for scientists in industry and academia who work in the areas of organic chemistry, medicinal chemistry, process chemistry, and analytical chemistry.

High-resolution NMR Techniques in Organic Chemistry

Author: Timothy D. W. Claridge

Publisher: Newnes

ISBN: 0080546285

Category: Mathematics

Page: 383

View: 3293

"Nuclear Magnetic Resonance (NMR) Spectroscopy remains the foremost analytical technique for the structure elucidation of organic molecules and an indispensable tool for the synthetic, medicinal and natural product chemist. New techniques continue to emerge and the application of NMR methods continues to expand. High-Resolution NMR Techniques in Organic Chemistry is designed for use in academic and industrial NMR facilities, as a text for graduate-level NMR courses, and as an accessible reference for the chemist's or spectroscopist's desk." --Book Jacket.

Dynamic Nuclear Magnetic Resonance Spectroscopy

Author: Lloyd Jackman

Publisher: Elsevier

ISBN: 032314358X

Category: Science

Page: 676

View: 3737

Dynamic Nuclear Magnetic Resonance Spectroscopy provides an overview of the state of knowledge in dynamic nuclear magnetic resonance (DNMR) spectroscopy. The early chapters describe the theoretical basis and practical techniques which have or will be used for extracting kinetic data from DNMR spectra. The subsequent chapters provide reviews of the many areas in which DNMR spectroscopy has been applied. Key topics covered include nuclear exchange processes; band-shape analysis; application of nonselective pulsed NMR experiments: diffusion and chemical exchange; spin-spin relaxation time determination; rotation about single and double bonds in organic molecules; and dynamic molecular processes in inorganic and organometallic compounds. Also discussed are studies on stereochemical nonrigidity in organometallic and metal carbonyl compounds; fluxional allyl complexes; carbonium ion rearrangements; and proton transfer processes. It is hoped that this volume will provide a literature guide, source book, and progress report which will be helpful to all those who will continue or will begin work in this field.

Understanding NMR Spectroscopy

Author: James Keeler

Publisher: John Wiley & Sons

ISBN: 1119964938

Category: Science

Page: 526

View: 6150

This text is aimed at people who have some familiarity with high-resolution NMR and who wish to deepen their understanding of how NMR experiments actually ‘work’. This revised and updated edition takes the same approach as the highly-acclaimed first edition. The text concentrates on the description of commonly-used experiments and explains in detail the theory behind how such experiments work. The quantum mechanical tools needed to analyse pulse sequences are introduced set by step, but the approach is relatively informal with the emphasis on obtaining a good understanding of how the experiments actually work. The use of two-colour printing and a new larger format improves the readability of the text. In addition, a number of new topics have been introduced: How product operators can be extended to describe experiments in AX2 and AX3 spin systems, thus making it possible to discuss the important APT, INEPT and DEPT experiments often used in carbon-13 NMR. Spin system analysis i.e. how shifts and couplings can be extracted from strongly-coupled (second-order) spectra. How the presence of chemically equivalent spins leads to spectral features which are somewhat unusual and possibly misleading, even at high magnetic fields. A discussion of chemical exchange effects has been introduced in order to help with the explanation of transverse relaxation. The double-quantum spectroscopy of a three-spin system is now considered in more detail. Reviews of the First Edition “For anyone wishing to know what really goes on in their NMR experiments, I would highly recommend this book” – Chemistry World “…I warmly recommend for budding NMR spectroscopists, or others who wish to deepen their understanding of elementary NMR theory or theoretical tools” – Magnetic Resonance in Chemistry

Nuclear Magnetic Resonance Probes of Molecular Dynamics

Author: R. Tycko

Publisher: Springer Science & Business Media

ISBN: 9781402014598

Category: Science

Page: 551

View: 6009

Nuclear Magnetic Resonance Probes of Molecular Dynamics describes the theoretical basis and experimental techniques that make modern NMR spectroscopy a powerful and flexible tool for probing molecular dynamics in chemical, physical, and biochemical systems. Individual chapters, written by leaders in the development and application of NMR from around the world, treat systems that range from synthetic polymers, liquid crystals, and catalysts to proteins and oligonucleotides and techniques that include deuterium NMR, magic angle spinning, multidimensional spectroscopy, and magnetic resonance imaging. A combination of elementary and advanced material makes the book a useful introduction to the field for students at the graduate level as well as an important reference for practising NMR spectroscopists.

Spin Dynamics

Basics of Nuclear Magnetic Resonance

Author: Malcolm H. Levitt

Publisher: Wiley

ISBN: 0470517123

Category: Science

Page: 744

View: 7345

Spin Dynamics: Basics of Nuclear Magnetic Resonance, Second Edition is a comprehensive and modern introduction which focuses on those essential principles and concepts needed for a thorough understanding of the subject, rather than the practical aspects. The quantum theory of nuclear magnets is presented within a strong physical framework, supported by figures. The book assumes only a basic knowledge of complex numbers and matrices, and provides the reader with numerous worked examples and exercises to encourage understanding. With the explicit aim of carefully developing the subject from the beginning, the text starts with coverage of quarks and nucleons and progresses through to a detailed explanation of several important NMR experiments, including NMR imaging, COSY, NOESY and TROSY. Completely revised and updated, the Second Edition features new material on the properties and distributions of isotopes, chemical shift anisotropy and quadrupolar interactions, Pake patterns, spin echoes, slice selection in NMR imaging, and a complete new chapter on the NMR spectroscopy of quadrupolar nuclei. New appendices have been included on Euler angles, and coherence selection by field gradients. As in the first edition, all material is heavily supported by graphics, much of which is new to this edition. Written for undergraduates and postgraduate students taking a first course in NMR spectroscopy and for those needing an up-to-date account of the subject, this multi-disciplinary book will appeal to chemical, physical, material, life, medical, earth and environmental scientists. The detailed physical insights will also make the book of interest for experienced spectroscopists and NMR researchers. • An accessible and carefully written introduction, designed to help students to fully understand this complex and dynamic subject • Takes a multi-disciplinary approach, focusing on basic principles and concepts rather than the more practical aspects • Presents a strong pedagogical approach throughout, with emphasis placed on individual spins to aid understanding • Includes numerous worked examples, problems, further reading and additional notes Praise from the reviews of the First Edition: "This is an excellent book... that many teachers of NMR spectroscopy will cherish... It deserves to be a ‘classic’ among NMR spectroscopy texts." NMR IN BIOMEDICINE "I strongly recommend this book to everyone…it is probably the best modern comprehensive description of the subject." ANGEWANDTE CHEMIE, INTERNATIONAL EDITION

NMR Spectroscopy in Liquids and Solids

Author: Vladimir I. Bakhmutov

Publisher: CRC Press

ISBN: 148226272X

Category: Medical

Page: 360

View: 5605

NMR Spectroscopy in Liquids and Solids provides an introduction of the general concepts behind Nuclear Magnetic Resonance (NMR) and its applications, including how to perform adequate NMR experiments and interpret data collected in liquids and solids to characterize molecule systems in terms of their structure and dynamics. The book is composed of ten chapters. The first three chapters consider the theoretical basis of NMR spectroscopy, the theory of NMR relaxation, and the practice of relaxation measurements. The middle chapters discuss the general aspects of molecular dynamics and their relationships to NMR, NMR spectroscopy and relaxation studies in solutions, and special issues related to NMR in solutions. The remaining chapters introduce general principles and strategies involved in solid-state NMR studies, provide examples of applications of relaxation for the determination of molecular dynamics in diamagnetic solids, and discuss special issues related to solid state NMR— including NMR relaxation in paramagnetic solids. All chapters are accompanied by references and recommended literature for further reading. Many practical examples of multinuclear NMR and relaxation experiments and their interpretations are also presented. The book is ideal for scientists new to NMR, students, and investigators working in the areas of chemistry, biochemistry, biology, pharmaceutical sciences, or materials science.

NMR and Chemistry

An introduction to modern NMR spectroscopy, Fourth Edition

Author: J.W. Akitt,B. E. Mann

Publisher: CRC Press

ISBN: 9780748743445

Category: Science

Page: 400

View: 1900

Keeping mathematics to a minimum, this book introduces nuclear properties, nuclear screening, chemical shift, spin-spin coupling, and relaxation. It is one of the few books that provides the student with the physical background to NMR spectroscopy from the point of view of the whole of the periodic table rather than concentrating on the narrow applications of 1H and 13C NMR spectroscopy. Aids to structure determination, such as decoupling, the nuclear Overhauser effect, INEPT, DEPT, and special editing, and two dimensional NMR spectroscopy are discussed in detail with examples, including the complete assignment of the 1H and 13C NMR spectra of D-amygdain. The authors examine the requirements of a modern spectrometer and the effects of pulses and discuss the effects of dynamic processes as a function of temperature or pressure on NMR spectra. The book concludes with chapters on some of the applications of NMR spectroscopy to medical and non-medical imaging techniques and solid state chemistry of both I = F1/2 and I > F1/2 nuclei. Examples and problems, mainly from the recent inorganic/organometallic chemistry literature support the text throughout. Brief answers to all the problems are provided in the text with full answers at the end of the book.

NMR Spectroscopy Explained

Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology

Author: Neil E. Jacobsen

Publisher: John Wiley & Sons

ISBN: 9780470173343

Category: Science

Page: 640

View: 705

NMR Spectroscopy Explained : Simplified Theory, Applications and Examples for Organic Chemistry and Structural Biology provides a fresh, practical guide to NMR for both students and practitioners, in a clearly written and non-mathematical format. It gives the reader an intermediate level theoretical basis for understanding laboratory applications, developing concepts gradually within the context of examples and useful experiments. Introduces students to modern NMR as applied to analysis of organic compounds. Presents material in a clear, conversational style that is appealing to students. Contains comprehensive coverage of how NMR experiments actually work. Combines basic ideas with practical implementation of the spectrometer. Provides an intermediate level theoretical basis for understanding laboratory experiments. Develops concepts gradually within the context of examples and useful experiments. Introduces the product operator formalism after introducing the simpler (but limited) vector model.

Hyperpolarized Xenon-129 Magnetic Resonance

Concepts, Production, Techniques and Applications

Author: Thomas Meersmann,Eike Brunner

Publisher: Royal Society of Chemistry

ISBN: 1782628371

Category: Science

Page: 472

View: 3525

Providing the first comprehensive book on the current state of hyperpolarized Xenon-129 NMR and MRI, this book is guaranteed to appeal to a wide range of scientists interested in this growing field. It is intended to create synergy between the various communities working with this noble gas. Covering all topics from the production of the hyperpolarized gas to its applications, the editors have invited a leading team of experts to combine the physical chemistry within the various topics and across disciplines. The scope will range from the fundamental aspects of optical pumping to practical aspects of hyperpolarizers and hp-xenon handling. The applications section will focus on hyperpolarized xenon-129 detected in the dissolved phase or micro porous media where the chemical shift of xenon-129 can be used as a diagnostic probe. Appealing to researchers in the biomedical field and materials sciences, this reference book will provide background reading and future looking material in one place.

Applied NMR Spectroscopy for Chemists and Life Scientists

Author: Oliver Zerbe,Simon Jurt

Publisher: John Wiley & Sons

ISBN: 3527677836

Category: Science

Page: 548

View: 5865

From complex structure elucidation to biomolecular interactions - this applicationoriented textbook covers both theory and practice of modern NMR applications. Part one sets the stage with a general description of NMR introducing important parameters such as the chemical shift and scalar or dipolar couplings. Part two describes the theory behind NMR, providing a profound understanding of the involved spin physics, deliberately kept shorter than in other NMR textbooks, and without a rigorous mathematical treatment of all the physico-chemical computations. Part three discusses technical and practical aspects of how to use NMR. Important phenomena such as relaxation, exchange, or the nuclear Overhauser effects and the methods of modern NMR spectroscopy including multidimensional experiments, solid state NMR, and the measurement of molecular interactions are the subject of part four. The final part explains the use of NMR for the structure determination of selected classes of complex biomolecules, from steroids to peptides or proteins, nucleic acids, and carbohydrates. For chemists as well as users of NMR technology in the biological sciences.

Multinuclear Solid-State Nuclear Magnetic Resonance of Inorganic Materials

Author: Kenneth J.D. MacKenzie,M.E. Smith

Publisher: Elsevier

ISBN: 9780080537108

Category: Science

Page: 748

View: 4401

Techniques of solid state nuclear magnetic resonance (NMR) spectroscopy are constantly being extended to a more diverse range of materials, pressing into service an ever-expanding range of nuclides including some previously considered too intractable to provide usable results. At the same time, new developments in both hardware and software are being introduced and refined. This book covers the most important of these new developments. With sections addressed to non-specialist researchers (providing accessible answers to the most common questions about the theory and practice of NMR asked by novices) as well as a more specialised and up-to-date treatment of the most important areas of inorganic materials research to which NMR has application, this book should be useful to NMR users whatever their level of expertise and whatever inorganic materials they wish to study.

NMR spectroscopy

basic principles, concepts, and applications in chemistry

Author: Harald Günther

Publisher: John Wiley & Sons Inc


Category: Science

Page: 581

View: 9230

As with its predecessor, this edition uses a practical non-mathematical approach. Features a number of recent developments in the field including two-dimensional methods, solid state NMR and an enlarged treatment of Fourier Transform methods. Contains numerous two-color diagrams.

Organic Structure Determination Using 2-D NMR Spectroscopy

A Problem-based Approach

Author: Jeffrey H. Simpson

Publisher: Academic Press

ISBN: 0123849705

Category: Science

Page: 574

View: 4907

"The second edition of this book comes with a number of new figures, passages, and problems. Increasing the number of figures from 290 to 448 has necessarily added considerable length, weight, and, expense. It is my hope that the book has not lost any of its readability and accessibility. I firmly believe that most of the concepts needed to learn organic structure determination using nuclear magnetic resonance spectroscopy do not require an extensive mathematical background. It is my hope that the manner in which the material contained in this book is presented both reflects and validates this belief"--

17 0 NMR Spectroscopy in Organic Chemistry

Author: David W. Boykin

Publisher: CRC Press

ISBN: 9780849348679

Category: Science

Page: 336

View: 4140

This book provides a comprehensive review of the application of 17O NMR spectroscopy to organic chemistry. Topics include the theoretical aspects of chemical shift, quadrupolar and J coupling; 17O enrichment; the effect of steric interactions on 17O chemical shifts of functional groups in flexible and rigid systems; the application of 17O NMR spectroscopy to hydrogen bonding investigations; mechanistic problems in organic and bioorganic chemistry; and 17O NMR spectroscopy of oxygen monocoordinated to carbon in alcohols, ethers, and derivatives. Recent results that show correlations between molecular geometry, determined by X-ray studies and estimated by molecular mechanics calculations, and 17O chemical shifts are also covered. 17O Spectroscopy in Organic Chemistry provides important reference information for organic chemists and other scientists interested in 17O NMR spectroscopy as a tool for obtaining new structural and chemical data about organic molecules.

Nuclear Magnetic Resonance

Author: R. K. Harris

Publisher: Royal Society of Chemistry

ISBN: 0851862527

Category: Medical

Page: 360

View: 3802

For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage.