p53 in the Clinics

Author: Pierre Hainaut,Magali Olivier,Klas G. Wiman

Publisher: Springer Science & Business Media

ISBN: 1461436761

Category: Medical

Page: 358

View: 2159

This project follows on the success of the book "25 years of p53", published by Springer in 2006. Since this publication, there have been considerable advances on the potential application of p53 into the clinics. The goal of this book is to capture these developments and to appeal to a clinical and medical audience beyond the one which was the primary target of "25 years of p53".

Breast Cancer Chemosensitivity

Author: Dihua Yu,Mien-Chie Hung

Publisher: Springer Science & Business Media

ISBN: 0387740392

Category: Medical

Page: 175

View: 9518

In Breast Cancer Chemosensitivity, a group of world leading experts review critical aspects of resistance to systemic therapy in breast cancer patients. Beginning with a clinical overview of the problem, the book then focuses on the latest findings of molecular mechanisms of drug resistance. Coverage provides an example of using novel approaches for chemosensitization of breast cancer cells that gives readers an idea about the future direction in breast cancer treatment. It allows those who are interested in breast cancer therapy to get a jump-start on critical issues in breast cancer therapeutic resistance.

25 Years of p53 Research

Author: Pierre Hainaut,Klas G. Wiman

Publisher: Springer Science & Business Media

ISBN: 9781402065644

Category: Medical

Page: 446

View: 6332

p53 has emerged as a key tumor suppressor and important target for novel cancer therapy. This book, written by world-leading p53 researchers including many of those who have shaped the field over the past 25 years, provides unique insights into the progress of the field and the prospects for better cancer diagnosis and therapy in the future.

The P53 Protein

From Cell Regulation to Cancer

Author: Arnold J. Levine,Guillermina Lozano

Publisher: N.A

ISBN: 9781621821335

Category: Medical

Page: 504

View: 3768

Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.


The Gene that Cracked the Cancer Code

Author: Sue Armstrong

Publisher: Bloomsbury Publishing

ISBN: 1472910532

Category: Health & Fitness

Page: 288

View: 3525

All of us have lurking in our DNA a most remarkable gene, which has a crucial job ? it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures ? the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge. This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives.

Lung Cancer, An Issue of Clinics in Chest Medicine - E-Book

Author: Lynn T. Tanoue,Richard A. Matthay

Publisher: Elsevier Health Sciences

ISBN: 1455709719

Category: Medical

Page: 311

View: 2922

Carcinoma of the lung is one of the most prevalent and aggressive types of cancer, and rates of lung cancer are on the rise. This issue gives a comprehensive review of the most recent advances in Lung Cancer. Epidemiology, etiology, and prevention of lung cancer is first discussed, followed by articles on pre-invasive evaluation and management, screening, pathology and molecular biology. There is an article on the approach to the ground glass nodule. Of great importance is the revised staging classification of Lung Cancer, which is discussed here in detail. Articles on PET imaging, interventional pulmonary, and functional evaluation before Lung Resection are also included. The issue then focuses on advances in treatment for early stage lung cancer, high risk patients with early stage lung cancer, advances in the treatment of Advanced Stage Lung Cancer, Small Cell Lung Cancer, and gene therapy for lung neoplasms.

Clinical Cytogenetics, An Issue of Clinics in Laboratory Medicine - E-Book

Author: Caroline Astbury

Publisher: Elsevier Health Sciences

ISBN: 1455709352

Category: Medical

Page: 385

View: 9614

This issue of Clinics in Laboratory Medicine, Guest Edited by Caroline Astbury, PhD, FACMG, will focus on Cytogenetics, with topics including: Chronic lymphocytic leukemia; Acute lymphocytic leukemia; Acute myelogenous leukemia; Chronic myelogenous leukemia; Plasma cell myeloma; Lymphomas; Solid tumors; Myelodysplastic syndromes; SNP arrays in clinical practice; Prenatal arrays; FISH (including Paraffin-embedded (PET) FISH); New and old microdeletion and microduplication syndromes; Sex chromosome and sex chromosome abnormalities; Autosomal aneuploidy; Microarray-CGH interpretation and Genomic Integrity; Structural chromosome rearrangements and complex chromosome rearrangements; and UPD/imprinting.

Pediatric Otolaryngology Challenges in Multi-System Disease, An Issue of Otolaryngologic Clinics - E-Book

Author: Austin Rose

Publisher: Elsevier Health Sciences

ISBN: 1455744247

Category: Medical

Page: 207

View: 966

Special "hazards" for otolaryngologists to be cognizant of in working with pediatric patients with concomitant disease are noted in this resource. Topics include: Hemangiomas in pediatric otolaryngology; Otolaryngologic manifestations of craniofacial syndromes; Pediatric otolaryngology manifestations of skeletal dysplasia; The otolaryngologist's approach to the down syndrome patient; Management of allergic fungal sinusitis in children; Multi-System disease and pediatric laryngotracheal reconstruction; Evaulation and management of velopalatal insufficiency; Recurrent Respiratory Papilomatosis; Pierre Robin Sequence – evaluation, management, timing of surgery and pitfalls; and Endoscopic skull base techniques for juvenile nasopharyngeal angiofibroma.

Molecular Pathology: An Update, An Issue of the Clinics in Laboratory Medicine, Ebook

Author: Martin H. Bluth

Publisher: Elsevier Health Sciences

ISBN: 0323610730

Category: Medical

Page: N.A

View: 8458

This updated issue of Clinics in Laboratory Medicine, edited by Martin H. Bluth, will focus on Molecular Pathology. Topics include, but are not limited to, The Impact of Molecular Pathology on the Practice of Pathology; Molecular pathology techniques; Clinical Implication of MicroRNAs in Molecular Pathology; Diagnostic Molecular Microbiology; Molecular Pathology in Transfusion Medicine; Molecular Diagnosis of Hematopoietic Neoplasms; Molecular Diagnostics in Colorectal Carcinoma; Molecular Diagnostics in the Neoplasms of Small Intestine and Appendix; Molecular Diagnostics in Esophageal and Gastric Neoplasms; Molecular Diagnostics in the Neoplasms of the Pancreas, Liver, Gall Bladder, and Extrahepatic Biliary Tract; Current Applications of Molecular Genetic Technologies to the Diagnosis and Treatment of Cutaneous Melanocytic Neoplasms; Breast Carcinoma; and Gynecologic Cancers.

Testes Cancer, An Issue of Hematology/Oncology Clinics of North America - E-Book

Author: Timothy Gilligan

Publisher: Elsevier Health Sciences

ISBN: 1455712566

Category: Medical

Page: 208

View: 5995

Dr. Gilligan has recruited global experts to contribute articles on the topic of testes cancer. The issue is organized to mimic the clinical process of detection, treatment, and management. Included in the issue are articles on the biology, interpretation, and imaging of germ cell tumors; early stage and stage II of seminomas and nonseminomas; first, second, and third line of chemotherapy for disseminated germ cell tumors, resection of residual masses, and treatment of brain metastases.

Management of Gastric Cancer, An Issue of Surgical Oncology Clinics - E-Book

Author: Neal Wilkinson

Publisher: Elsevier Health Sciences

ISBN: 1455743178

Category: Medical

Page: 204

View: 3340

This issue of Surgical Oncology Clinics of North America, Guest Edited by Neal Wilkinson, MD, is devoted to the Management of Gastric Cancer. Articles in this issue will focus on Epidemiology; Genetics and Prophylactic Surgery; Endoscopic Diagnosis & Staging; Gastric Stromal Tumors (GIST); Management of Early Stage Gastric Cancer; Endoscopic Mucosal Resection (EMR); Tailored Lymphadenectomy; Laparoscopic Resection Gastric Cancer - Western Experience; Gastric Cancer - Eastern Experience; Update of Gastric Cancer Clinical Trials; Preoperative and Postoperative Chemotherapy for Gastric Cancer; and Phase I and II Clinical Trials.

Evaluation of the Surgical Margin, An Issue of Oral and Maxillofacial Clinics of North America, E-Book

Author: Joshua Lubek,Kelly Magliocca

Publisher: Elsevier Health Sciences

ISBN: 0323532489

Category: Medical

Page: N.A

View: 920

This issue of Oral and Maxillofacial Surgery Clinics of North America focuses on Evaluation of the Surgical Margin, and is edited by Drs. Joshua E. Lubek and Kelly Magliocca. Articles will include: Understanding the Surgical Margin: A Pathologist’s Perspective; Understanding the Surgical Margin: A Molecular Assessment; Margin Analysis: Squamous Cell Carcinoma of the Oral Cavity; Margin Analysis: Squamous Cell Carcinoma of the Oropharynx; Bone Margin Analysis: Segmental Versus Marginal Resection in Malignant Disease; Bone Margin Analysis for Benign Odontogenic Tumors; Bone Margin Analysis for Osteonecrosis and Osteomyelitis of the Jaws; Margin Analysis: Malignant Salivary Gland Neoplasms of the Head and Neck; Margin Analysis: Benign Salivary Gland Neoplasms of the Head and Neck; Margin Analysis: Cutaneous Malignancy of the Head and Neck; Margin Analysis: Sarcoma of the Head and Neck; Has Reconstruction Improved Tumor Surgery Outcomes?; and more!

Advances in Neurologic Therapy, An Issue of Neurologic Clinics - E-Book

Author: José Biller

Publisher: Elsevier Health Sciences

ISBN: 1455700444

Category: Medical

Page: 297

View: 9205

This issue of Neurologic Clinics offers a rounded view of the latest therapeutic advances for the most common neurologic disorders and contains the following articles: Management Controversy in Chronic Daily Headaches (Rahmadan); Neurostimulation in Headache Patients (Dafer); The Selection of Anti-epileptic Drugs for the Treatment of Epilepsy in Children and Adults (Asconape); Management of Status Epilepticus in Adults (Rabinstein); Management of Blood Pressure in Acute and Hemorrhagic Stroke (Schneck); Modern Management of Brainstem Cavernous Malformations (Duckworth); Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas (Narayanan); Management of Motor Complications of Parkinson’s Disease (Espay); Therapeutic Challenges in Dystonias (Kartha); Management of Voltage Gated Potassium Channel Antibody Disorders (Merchut); Management of Critical Care Neuromyopathies (Chawla, Gruener); Approaches to Peripheral Nerve Disorders (Toussaint, Anderson); Management of Idiopathic Intracranial Hypertension (Digre, Spencer); Management of Low Grade Gliomas (Prabhu); Management of Acute, Recurrent, and Chronic Meningitdes in Adults (Venna); and Treatment Options for Adult Parasomnias (Attarian).

Heart Diseases: Advances in Research and Treatment: 2011 Edition

Author: N.A

Publisher: ScholarlyEditions

ISBN: 1464921024

Category: Medical

Page: 758

View: 7662

Heart Diseases: Advances in Research and Treatment: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Heart Diseases. The editors have built Heart Diseases: Advances in Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Heart Diseases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Heart Diseases: Advances in Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

NanoOncology, An Issue of Clinics in Laboratory Medicine - E-Book

Author: Kewal Jain

Publisher: Elsevier Health Sciences

ISBN: 1455742899

Category: Medical

Page: 120

View: 4587

This issue of Clinics in Laboratory Medicine includes the following topics: Detection of cancer biomarkers by cerium oxide nanoparticles; Quantum dot-based assays for cancer biomarkers; Monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo diagnosis of cancer; RNA quantification with gold nanoprobes for cancer diagnostics; Nanostructured silica materials for imaging in cancer; and Nanoparticle-based cancer cell sorting.

Psoriasis: Advances in Knowledge and Care, An Issue of Dermatologic Clinics,

Author: Alan Menter

Publisher: Elsevier Health Sciences

ISBN: 0323341918

Category: Medical

Page: 194

View: 4747

Psoriasis is the most prevalent autoimmune disease in the U.S. • ~125 million people worldwide have psoriasis. Commonly misunderstood and interpreted as a “cosmetic problem, psoriasis is a complex and potentially debilitating disease; nearly 60% of people with psoriasis reported their disease to be a large problem in their everyday life. This issue of Dermatologic Clinics devoted exclusively to psoriasis is edited by two leaders of the International Psoriasis Council, Dr Alan Menter and Dr Chris Griffiths. Topics include: Genetics of psoriasis; Immunopathogenesis of psoriasis; Phenotypical expressions of psoriasis; Psoriasis as a systemic disease with multiple comorbidities; Outcomes measures in the assessment of psoriasis in clinical practice and trials; Update on topical therapies for mild to moderate psoriasis; Phototherapy and photochemotherapy (PUVA) for psoriasis; Current and future oral systemic therapies for psoriasis; Current biological therapies for psoriasis; Future biological therapies for psoriasis; Psoriatic arthritis for the dermatologist; Pharmacogenomics and the future of psoriasis therapies. This information that goes to the heart of clinical practice is equally appropriate, beyond dermatologists, for internal medicine clinicians, primary care physicians, bone & joint specialists; hematologists/oncologists, and researchers in genetic targeted therapy development.

Photodermatology, An Issue of Dermatologic Clinics,

Author: Henry Lim

Publisher: Elsevier Health Sciences

ISBN: 0323311806

Category: Medical

Page: 217

View: 8790

Dr Henry Lim, renown for expertise and research in photodermatology leads this issue of Dermatologic Clinics. Photodermatology in this issue addresses dermatoses brought on or accelerated by light as well as light forms for dermatology therapies. Photodermatology is used to diagnosis and treat many common conditions that bring patients to the dermatologist. Topics include: Introduction to photobiology; Evaluation of patients with photodermatologic conditions; Photoimmunology; Photoaging; Photocarcinogenesis; Polymorphous Light Eruption (PMLE); Actinic Prurigo; Hydroa vacciniforme and solar urticaria; Chronic actinic dermatitis; drug-induced photosensitivity; Cutaneous porphyrias; Photoaggravated dermatoses; Ultraviolet (UV) based therapy; Photodynamic therapy; Photoprotection. Dr Lim works with one his residents, So Yeon Paek, as his co-Editor on this issue.

Cytopathology, An Issue of Surgical Pathology Clinics,

Author: Tarik El Sheikh

Publisher: Elsevier Health Sciences

ISBN: 0323261337

Category: Medical

Page: 145

View: 1624

Topics that are essential to the surgical pathologist in cytopathology are included in this issue of Surgical Pathology Clinics. Topics include cytopathology of the Thyroid; Pancreas, Salivary glands; Lung; Urine; Gynecologic; Metastasis of unknown origin; and Preparation techniques and Cell transfer. Expert cytopathologist and prolific author and researcher and expert clinician Tarik Elsheikh leads this issue as Guest Editor.