Ocular Theraputics and Drug Delivery

Author: Indra K. Reddy

Publisher: CRC Press

ISBN: 9781566762137

Category: Medical

Page: 587

View: 7185

Since ocular therapeutics and drug delivery is a subject of interest to specialists from various disciplines such as chemical, biochemical, medical, pharmaceutical, and toxicological, it truly presents a unique situation requiring a multi-disciplinary approach in understanding and addressing various problems. Yet we see that scientists associated with these areas are working, by and large, independently of one another, thus limiting dissemination of knowledge, experience and ideas that would greatly enhance the overall progress in this area of research. Regrettably, the information currently available in ocular therapeutics and drug delivery, though extensive, is still fragmented into various disciplines making meaningful synthesis difficult. Several books are available that cover one or two aspects of the multi-disciplinary fields on an individual basis; however, none is available that covers all of them. The chapters contained in this book are specific to various interrelated areas of ocular therapeutics and drug delivery and are written by acknowledged experts from both academia and industry. The book itself is divided into five parts, namely: (I) overview,basic principles, and methodology; (II) pathopharmacology and clinical applications; (III) chemical/ biochemical approaches to ocular drug delivery; (IV) formulation and drug delivery considerations; and (V) industrial and regulatory considerations. Individual chapters in each section, apart from presenting a concise text, entail an extensive listing of references.

Ocular Therapeutics

Eye on New Discoveries

Author: Thomas Yorio,Abbott Clark,Martin B Wax

Publisher: Academic Press

ISBN: 9780080556772

Category: Science

Page: 536

View: 815

Ocular Therapeutics: Eye on New Discovery focuses on emerging areas in ocular research, from new approaches to dry eye to gene therapy in the management of retinal diseases. This comprehensive book features more than 25 chapters of information that will be vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. It is the intent of this book to provide not only information on current approaches to treatment, but also in giving the reader a greater understanding as to what may become available for treating a number of important eye diseases. Each chapter features some new aspect of treatment that holds great promise for the future. The approach has been to concentrate on those areas of ocular diseases that are more prevalent. It also features new insight for drug delivery and for managing devasting diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States. This book will serve as an important resource as it contains a number of relevant references highlighted for their importance to the field. New investigators will be able to obtain an historical perspective for each of the topics and to develop an understanding of the new research directions that are underway. Ocular Therapeutics: Eye on New Discovery is more than a reference book, as it also provides an important glimpse into the near future. * Contains information that is vital for ocular investigators and ophthalmologists bringing them new information on promising therapeutics. * Provides not only information on current approaches to treatment, but also gives the reader a greater understanding as to what may become available for treating a number of important eye diseases. * Historical perspective for each of the topics as well as an important glimpse into the near future to develop an understanding of the new research directions underway. * New insight for drug delivery and for managing devastating diseases, such as macula edema and glaucoma, two of the leading causes of blindness in the United States

Pharmacology of Ocular Therapeutics

Author: Thirumurthy Velpandian

Publisher: Springer

ISBN: 3319254987

Category: Medical

Page: 535

View: 6859

This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular drug therapy by compiling all key aspects of the pharmacology, toxicology, pharmaceutical science, ocular biochemistry and cell biology of these agents. Chapters detail drug transfer across barriers, systemic toxicity of topically applied drugs, autonomic drugs used for diagnostics, as well as anti-inflammatory, antiallergic, glaucoma and antimicrobial therapies, and avenues for the development of new ocular drugs. Applications of extemporaneously prepared formulations are described to inform day-to-day clinical practice. The use of mucoadhesive polymers in tear substitutes, ocular drug delivery systems, stem cell therapy, pharmacogenomics and antiangiogenic ocular chemotherapy are also explored. The book also provides insights from drugs of herbal origin, and a historical perspective on drugs for ocular use. Practicing and resident ophthalmologists, optometrists, pharmacists, nursing professionals, scholars in ocular drug research and students will equally benefit from this comprehensive guide.

Ocular Therapeutics

Author: Ashok Garg

Publisher: JP Medical Ltd

ISBN: 9350903202

Category: Medical

Page: 1094

View: 4265

The third edition of Ocular Therapeutics brings practitioners up to date with the latest advances in ophthalmic drugs. Divided into three sections, the book begins with discussion on the physiology of the eye, drug administration and the fundamental role of ocular therapeutics. The second section examines the application of ocular therapeutics in ophthalmic surgery for many different disorders and the final section discusses recent advances and future developments. This new edition has been fully updated with the addition of new drugs and delivery systems, covering all groups of drugs used worldwide in different clinical conditions of the eye. Written by recognised international experts, many from the USA, the book is presented in an easy to read format and includes nearly 430 well-illustrated colour figures, tables, flow diagrams and chemical formulas. Key points New edition bringing ophthalmologists up to date with latest advances in ophthalmic drugs Includes new drugs and delivery systems for all groups of drugs used worldwide Written by recognised international experts Nearly 430 figures, tables, flow diagrams and chemical formulas Previous edition published in 2006

Ocular Angiogenesis

Diseases, Mechanisms, and Therapeutics

Author: Joyce Tombran-Tink,Colin J. Barnstable

Publisher: Springer Science & Business Media

ISBN: 1597450472

Category: Medical

Page: 412

View: 7721

Leading academic and pharmaceutical researchers and clinicians from many disciplines synthesize and summarize current clinical and basic knowledge concerning abnormal growth of blood vessels in the eye, the cause of major neovascular eye diseases. The authors also identify and assess the most promising approaches with potential for commercial exploitation and discuss the challenges encountered in developing therapeutics for ocular neovascular diseases. Highlights include illuminating chapters on gene therapy and novel drug delivery systems and excellent summaries of the newest therapeutic approaches.

Ocular Drug Delivery: Advances, Challenges and Applications

Author: Richard T. Addo

Publisher: Springer

ISBN: 3319476912

Category: Medical

Page: 185

View: 6350

The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye. Therefore, ocular drug delivery has been a major challenge to drug delivery researchers. There are on-going studies, in search of treatment especially for the diseases affecting the posterior segment of the eye. This book gives and overview of the background of ocular drug delivery and is unique for pharmacists, medical practitioners, students and drug delivery researchers.

Nanoarchitectonics for Smart Delivery and Drug Targeting

Author: Alina Maria Holban,Alexandru Mihai Grumezescu

Publisher: William Andrew

ISBN: 0323477224

Category: Technology & Engineering

Page: 970

View: 5492

Nanoarchitectonics for Smart Delivery and Drug Targeting is one of the first books on the market to exclusively focus on the topic of nanoarchitectonics, a rapidly developing area of nanotechnology which allows scientists to arrange nanoscale structural units, typically a group of atoms or molecules, in an intended configuration. This book assesses novel applications of nanomaterials in the areas of smart delivery and drug targeting using nanoarchitectonics and discusses the advantages and disadvantages of each application. Provides a scholarly introduction to the uses of nanoarchitectonics in drug delivery and targeting Explores novel opportunities and ideas for developing and improving nanoscale drug delivery systems through the use of nanoarchitectonics, allowing scientists to see how this exciting new technology is used in practice Assesses the pros and cons of each application, allowing readers to assess when it is most appropriate to use nanoarchitectonics in drug delivery

Ocular Pharmacology and Therapeutics

A Primary Care Guide

Author: Michael J. Doughty

Publisher: Butterworth-Heinemann Medical

ISBN: 9780750645201

Category: Medical

Page: 132

View: 4213

This is the third volume in the series based on a popular and well-received set of articles published in Optician magazine, and thoroughly updated to incorporate the latest drug information. It is comprehensive in its coverage of all issues relating to ocular therapeutics -- from record keeping for patient medications through to the basic pharmacology of drug delivery to the eye; systemic medications and drugs with their indications and contraindications for use.

Peptide and Protein Delivery

Author: Chris Van Der Walle

Publisher: Academic Press

ISBN: 9780123849366

Category: Science

Page: 380

View: 503

The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market

Ocular Drug Delivery Systems

Barriers and Application of Nanoparticulate Systems

Author: Deepak Thassu,Gerald J. Chader

Publisher: CRC Press

ISBN: 1439848017

Category: Medical

Page: 473

View: 4504

Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends in the topical delivery of drugs to the posterior of the eye. With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book presents the state of the art in the use of nanoparticles in ocular drug delivery systems and also sets the stage for future developments. This volume provides both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist. It also explores areas where effective drugs may be currently available but yet need a safe, efficient, and efficacious delivery vehicle.

Drug Product Development for the Back of the Eye

Author: Uday B. Kompella,Henry F. Edelhauser

Publisher: Springer Science & Business Media

ISBN: 1441999205

Category: Medical

Page: 592

View: 9910

This comprehensive volume discusses approaches for a systematic selection of delivery systems for various classes of therapeutic agents including small molecule, protein, and nucleic acid drugs. Specific topics covered in this book include: Solution, suspension, gel, nanoparticle, microparticle, and implant dosage forms Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering. Refillable and microneedle devices Intravitreal, suprachoroidal, intrascleral, transscleral, systemic, and topical routes of delivery Physical methods including iontophoresis for drug delivery Rational selection of routes of administration and delivery systems Noninvasive and continuous drug monitoring Regulatory path to drug product development Clinical endpoints for drug product development Emerging and existing drugs and drug targets Drug Product Development for the Back of the Eye is authored by renowned ocular drug delivery experts, representing academic, clinical, and industrial organizations and serves as indispensable resource for ophthalmic researchers, drug formulation scientists, drug delivery and drug disposition scientists, as well as clinicians involved in designing and developing novel therapeutics for the back of the eye diseases. This book is also relevant for students in various disciplines including ophthalmology, pharmaceutical sciences, drug delivery, and biomedical engineering.

Textbook on Clinical Ocular Pharmacology & Therapeutics

Author: Renu Agarwal,Sushma Srivastava

Publisher: JP Medical Ltd

ISBN: 9351523411

Category: Medical

Page: 354

View: 2840

This book is a comprehensive guide to ocular pharmacology for trainees and practising ophthalmologists. Beginning with the basic physiological aspects of ocular pharmacology and ophthalmic drug administration, the following sections discuss different types of drugs used in the treatment of eye disease. The final sections examine contact lens care systems, nutritional supplements and adverse effects of systematically administered drugs into the eye. This useful, quick reference text is highly illustrated with more than 145 images and tables. Key points Comprehensive guide to ocular pharmacology for trainees and practising ophthalmologists Covers different drugs for treatment of eye diseases Includes section on adverse effects of systematically administered drugs Highly illustrated with more than 145 images and tables

Organic Materials as Smart Nanocarriers for Drug Delivery

Author: Alexandru Mihai Grumezescu

Publisher: William Andrew

ISBN: 0128136642

Category: Science

Page: 768

View: 1184

Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems

Treatise on Ocular Drug Delivery

Author: Ashim K. Mitra

Publisher: Bentham Science Publishers

ISBN: 1608051757

Category: Medical

Page: 301

View: 1931

A multidisciplinary approach is increasingly being adapted by the Pharmaceutical industry to tackle several challenges in developing efficacious treatment solutions. The field of Ophthalmology is no less different. Treatise on Ocular Drug Delivery is a unique collection of information put together by various experts in the field. One of the major goals behind this volume is to link clinical information with the current strategies employed in ocular drug delivery. This monograph covers a range of topics on ocular pharmacology. Chapters in the e-book cover several aspects of drug delivery research such as the biochemical background of specific eye diseases, challenges for ocular drug delivery, the role of influx and efflux transporters, novel drug delivery systems, pharmacokinetics, regulatory aspects, and patenting opportunities for researchers. This E-Book would serve as a suitable reference for pharmacy graduates, medical students, professional scientists and ophthalmic clinicians in academic and industrial laboratories.

Ophthalmic Drugs

Diagnostic and Therapeutic Uses

Author: Graham Hopkins,Richard M. Pearson

Publisher: Elsevier Health Sciences

ISBN: 0750688645

Category: Medical

Page: 331

View: 5949

Providing information on ocular therapeutics, this edition offers a basic grounding in pharmacological principles and drug types. It then moves on to common ocular conditions, showing how they can be diagnosed and treated using ocular therapeutics. It also contains many clinical notes and ready-reference tables.

Ocular Therapeutics Handbook

A Clinical Manual

Author: Bruce E. Onofrey,Leonid Skorin,Nicky R. Holdeman

Publisher: Lippincott Williams & Wilkins

ISBN: 1451153708

Category: Medical

Page: 736

View: 8914

Ocular Therapeutics Handbook: A Clinical Manual is directed at the needs of optometrists, nurses and primary care physicians and provides succinct, rapid access information for most common ocular problems encountered in a primary care setting. It is divided into three sections: Quick Reference, Ocular Therapeutics and Appendices. The Quick Reference section covers such topics as ocular microbiology, lab tests and procedures, pharmaceutical agents, and side effects of medications. The Ocular Therapeutics section discusses diseases, traumatic injuries, and ocular urgencies and emergencies. The appendices provide a summary of abbreviations, conversion charts, case report sheets and important phone numbers. The chapters have been developed to serve as a snapshot, presenting the clinician with the most relevant information regarding the pathophysiology and etiology of diseases, patient demographics, signs and symptoms, lab tests, and recommended approaches to treatment.

Complement Therapeutics

Author: John D. Lambris,V. Michael Holers,Daniel Ricklin

Publisher: Springer Science & Business Media

ISBN: 146144117X

Category: Medical

Page: 320

View: 2041

This book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials. The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system.

Clinical Ocular Pharmacology

Author: Jimmy D. Bartlett

Publisher: Elsevier

ISBN: 1483193918

Category: Medical

Page: 944

View: 4517

Clinical Ocular Pharmacology, Second Edition covers the diagnostic and therapeutic clinical procedures in the administration of drugs to the eye. This book is organized into five parts encompassing 35 chapters that evaluate the basic pharmacologic principles that govern the different types of ophthalmic drugs. It addresses the pharmacologic agents useful in the diagnosis and treatment of ocular diseases. Some of the topics covered in the book are the basic science of ocular pharmacology; clinical administration of ocular drugs; drugs affecting the autonomic nervous system; types of local anesthetics; review of anti-inflammatory drugs; and examination of inhibitors of aqueous formation. Other parts deal with the development of contact lens solution in clinical practice and the pharmacologic management of strabismus. These topics are followed by discussions of the legal basis of using drugs in optometry and the systemic effects of ocular drugs. The concluding part is devoted to the diseases of the optic nerve. The book can provide useful information to doctors, optometrists, pediatricians, students, and researchers.

Antibody-Mediated Drug Delivery Systems

Concepts, Technology, and Applications

Author: Yashwant Pathak,Simon Benita

Publisher: John Wiley & Sons

ISBN: 0470612819

Category: Medical

Page: 505

View: 4513

This book covers various aspects of antibody mediated drug delivery systems – theoretical aspects, processing, viral and non–viral vectors, and fields where these systems find and /or are being evaluated for applications as therapeutics and diagnostic treatment. Chapters discuss actual applications of techniques used for formulation and characterization. Applications areas include cancer, pulmonary, ocular diseases; brain drug delivery; and vaccine delivery. The contributing authors represent over 10 different countries, covering recent developments happening around the globe.

Ocular Drug Delivery: Advances, Challenges and Applications

Author: Richard T. Addo

Publisher: Springer

ISBN: 3319476912

Category: Medical

Page: 185

View: 7757

The eye is a computerized system that has been designed for self-defense, and these defense mechanisms create challenges in administration of medications to the eye. Therefore, ocular drug delivery has been a major challenge to drug delivery researchers. There are on-going studies, in search of treatment especially for the diseases affecting the posterior segment of the eye. This book gives and overview of the background of ocular drug delivery and is unique for pharmacists, medical practitioners, students and drug delivery researchers.