Molecular Imaging I

Author: Wolfhard Semmler,Markus Schwaiger

Publisher: Springer Science & Business Media

ISBN: 3540727183

Category: Medical

Page: 280

View: 8631

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Biomedical Imaging

The Chemistry of Labels, Probes and Contrast Agents

Author: Martin Braddock,David Rotella

Publisher: Royal Society of Chemistry

ISBN: 1849730148

Category: Medical

Page: 533

View: 8721

The focus of this new book is for medicinal chemists on the chemical agents that have been used, or might be required in the future, and the methods of synthesis for inserting the reporter groups. A key reference for academics, postgraduates, researchers, industrialists and professionals working in or joining this field.

MRT in der Gastroenterologie

MRT und bildgebende Differenzialdiagnose ; 29 Tabellen

Author: Henning E. Adamek

Publisher: Georg Thieme Verlag

ISBN: 9783131492913

Category: Gastrointestinale Krankheit - NMR-Tomographie - Lehrbuch

Page: 225

View: 2237


Molecular Imaging II

Author: Wolfhard Semmler,Markus Schwaiger

Publisher: Springer Science & Business Media

ISBN: 3540774963

Category: Medical

Page: 365

View: 9540

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Comprehensive Biomedical Physics

Author: N.A

Publisher: Newnes

ISBN: 0444536337

Category: Science

Page: 4056

View: 6865

Comprehensive Biomedical Physics is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color

Handbook of Targeted Delivery of Imaging Agents

Author: Vladimir P. Torchilin

Publisher: CRC Press

ISBN: 9780849383083

Category: Medical

Page: 752

View: 870

This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Handbook of Medical Imaging

Processing and Analysis Management

Author: N.A

Publisher: Academic Press

ISBN: 9780080533100

Category: Technology & Engineering

Page: 901

View: 9589

In recent years, the remarkable advances in medical imaging instruments have increased their use considerably for diagnostics as well as planning and follow-up of treatment. Emerging from the fields of radiology, medical physics and engineering, medical imaging no longer simply deals with the technology and interpretation of radiographic images. The limitless possibilities presented by computer science and technology, coupled with engineering advances in signal processing, optics and nuclear medicine have created the vastly expanded field of medical imaging. The Handbook of Medical Imaging is the first comprehensive compilation of the concepts and techniques used to analyze and manipulate medical images after they have been generated or digitized. The Handbook is organized in six sections that relate to the main functions needed for processing: enhancement, segmentation, quantification, registration, visualization as well as compression storage and telemedicine. * Internationally renowned authors(Johns Hopkins, Harvard, UCLA, Yale, Columbia, UCSF) * Includes imaging and visualization * Contains over 60 pages of stunning, four-color images

Grainger & Allison's Diagnostic Radiology E-Book

Author: Andy Adam,Adrian K. Dixon,Jonathan H Gillard,Cornelia Schaefer-Prokop,Ronald G. Grainger,David J. Allison

Publisher: Elsevier Health Sciences

ISBN: 070206128X

Category: Medical

Page: 2144

View: 8821

Effectively apply the latest techniques and approaches with complete updates throughout including 4 new sections (Abdominal Imaging, The Spine, Oncological Imaging, and Interventional Radiology) and 28 brand new chapters. Gain the fresh perspective of two new editors—Jonathan Gillard and Cornelia Schaefer-Prokop -- eight new section editors -- Michael Maher, Andrew Grainger, Philip O’Connor, Rolf Jager, Vicky Goh, Catherine Owens, Anna Maria Belli, Michael Lee -- and 135 new contributors. Stay current with the latest developments in imaging techniques such as CT, MR, ultrasound, and coverage of hot topics such as: Image guided biopsy and ablation techniques and Functional and molecular imaging. Solve even your toughest diagnostic challenges with guidance from nearly 4,000 outstanding illustrations. Quickly grasp the fundamentals you need to know through a more concise, streamlined format.

Molecular Imaging

Principles and Practice

Author: Ralph Weissleder

Publisher: PMPH-USA

ISBN: 9781607950059

Category: Medical

Page: 1357

View: 3099

The field of molecular imaging of living subjects have evolved considerably and have seen spectacular advances in chemistry, engineering and biomedical applications. This textbook was designed to fill the need for an authoritative source for this multi-disciplinary field. We have been fortunate to recruit over 80 leading authors contributing 75 individual chapters. Given the multidisciplinary nature of the field, the book is broken into six different sections: "Molecular Imaging technologies", "Chemistry", "Molecular Imaging in Cell and Molecular Biology", "Applications of Molecular Imaging", "Molecular Imaging in Drug Evaluation" with the final section comprised of chapters on computation, bioinformatics and modeling. The organization of this large amount of information is logical and strives to avoid redundancies among chapters. It encourages the use of figures to illustrate concepts and to provide numerous molecular imaging examples.

Handbook of Radiopharmaceuticals

Radiochemistry and Applications

Author: Michael J. Welch

Publisher: John Wiley & Sons

ISBN: 9780471495604

Category: Medical

Page: 848

View: 4289

The Handbook of Radiopharmaceuticals is an up-to-date,authoritative reference that introduces key issues relating to theproduction and application of radiopharmaceuticals. The book coversa wide range of radiochemistry and clinical applications includingthe production of various radionuclides, positron emissiontomography (PET) and drug development. Discussions on the uses ofradiopharmaceuticals in the diagnosis and therapy of cancer andother diseases are also included. Features include: * 28 Chapters contributed by world-renowned experts in thefield * All aspects of radiopharmaceutical production and applicationsare discussed Written by internationally recognised authors, the Handbook ofRadiopharmaceuticals is an invaluable resource for advancedgraduates and researchers within radiochemistry, analytical andorganic chemistry, drug delivery and pharmacokinetics, biochemistryand pharmacology. This book will also be of interest to clinicians,radiologists and radiographers involved in nuclear medicine andradiology. Radiopharmaceuticals are being increasingly utilized assurrogate markers in drug evaluations. This book will be useful toscientists involved in drug development.

Magnetresonanzbildgebung

Theorie und Praxis

Author: Marinus T. Vlaardingerbroek,Jacques A. Boer

Publisher: Springer-Verlag

ISBN: 3642186971

Category: Science

Page: 535

View: 9593

Das bekannte Lehrbuch zur Physik und Technik der kernmagnetischen Resonanz liegt jetzt auch in deutscher Sprache vor. Es beschreibt den physikalischen Hintergrund der Scan-Methoden und ihren Einsatz in der medizinischen Diagnostik. In diesem Zusammenhang werden auch neue Wege und Verfahren aufgezeigt. Besondere Aufmerksamkeit gilt der Behandlung von Artefakten und ihrer mathematischen Beschreibung. Das Buch ist mit vielen Illustrationen zu Scan-Verfahren, wie z.B. RARE, GRASE, EPI, Balanced FFE und Spiralscan ausgestattet. Detaillierte Aussagen über Echoamplituden in Multi-Echosequenzen, wie TSE, FFE und BURST sind in einem besonderen Kapitel mit Hilfe der Konfigurationstheorie ausführlich abgehandelt. Eine kurze Einführung in die Geschichte der MR-Bildgebung rundet dieses Buch ab.

Handbook of Cannabis

Author: Roger Pertwee

Publisher: OUP Oxford

ISBN: 0191639702

Category: Science

Page: 632

View: 602

Truly global in scope and with contributions from leading researchers around the world, The Handbook of Cannabis is the definitive resource on this fascinating drug. Combining scientific perspectives and clinical applications, it covers a vast array of topics, from why over the centuries cannabis has been used as a medicine, through the regulations facing those wishing to self-administer cannabis or provide cannabis-based medicines, to the chemical structure of its many constituents and the rapidly growing group of synthetic cannabinoids that are currently being used for 'legal highs'. With each chapter written by a group of one or more internationally recognised subject experts, it provides academics and researchers with authoritative scientific material on the main pharmacological actions and their effects, as well as their pharmacokinetics, metabolism, and forensic detection. In addition it also examines the complex morphology, cultivation, harvesting, and processing of cannabis and the ways in which the plant's chemical composition can be controlled. As well as offering a raft of scientific information there is extensive coverage of cannabinoid-based medicines. Helping readers to identify and evaluate their benefits, chapters explore pharmacological actions and the effects that seem to underlie approved therapeutic uses, how they are currently used to treat certain disorders, and the ever-growing number of wide-ranging potential clinical applications. There is also coverage of both the legal and illegal sources of cannabis, including 'coffee shops' and 'cannabis dispensaries'. The complex issue of 'recreational cannabis' is also tackled. The sought-after and adverse psychological and non-psychological effects are described and discussions are included on how some adverse effects can be lessened by at least one constituent of cannabis, and that it might be possible to reduce the harm that cannabis does to some by changing current regulatory policies. The Handbook of Cannabis is a one-stop reference; essential reading for all clinicians, pharmacologists, psychologists, and psychiatrists interested in this drug, as well as those working in the field of public health.

Antipsychotics

Author: John G. Csernansky

Publisher: Springer Science & Business Media

ISBN: 3642610072

Category: Medical

Page: 539

View: 9995

Antipsychotic drugs were first discovered in 1953, and not since the late 1970s has the Handbook of Experimental Pharmacology taken up this topic. A new treatment of this topic would be due under any circumstances; however, this is now particularly true, since remarkable progress has been made on several fronts in furthering our understanding of the mechanisms of antipsychotic drug action. First, we have learned that schizophrenia is an illness with particu lar neuroanatomical abnormalities, many of which suggest that the illness is caused by errors in neurodevelopment. These findings have helped to form a context for understanding neurochemical aberrations in the illness and suggest new approaches for pharmacological treatment. Propelled forward by rapid advances in neurochemical anatomy, current pathophysiological hypotheses of schizophrenia and antipsychotic drug action have taken on the appearance of complex electrical circuit diagrams. Second, molecular biology studies have now revealed that there is a multiplicity of dopamine receptors (i. e. , D , DZshort' j DZlong, D , D , and D ), some of which may become entirely new targets for 3 4 s antipsychotic drug action. Ironically, the development of drugs that are selec tive for these receptors and that can be used to investigate their function lags behind; yet the discovery of these new receptors offers unparalleled opportu nities for developing drugs with improved efficacy and fewer side effects.

Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology

Author: Saura C. Sahu,Daniel A. Casciano

Publisher: John Wiley & Sons

ISBN: 1118855868

Category: Science

Page: 440

View: 5891

The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

CNS Injuries

Cellular Responses and Pharmacological Strategies

Author: Martin Berry,Ann Logan

Publisher: CRC Press

ISBN: 9781420048544

Category: Medical

Page: 240

View: 5688

The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date examination of new developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including inflammatory and immune reactions scarring neuron death demyelination and remyelination axonal regeneration re-establishment of neuronal connectivity Providing a record of recent advances that will help point the way to future developments, this enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including: neurology, pharmacology, pathology, toxicology, immunology, and many others.

Clinical Pharmacology of Antianginal Drugs

Author: U. Abshagen

Publisher: Springer Science & Business Media

ISBN: 3642695248

Category: Medical

Page: 552

View: 4825

When I was asked some years ago by the editors of the Handbook of Experimental Pharmacology to edit a new volume on Antianginal Drugs, I agreed on the condition that, in accordance with my scientific background, primary emphasis be given to clinical pharmacology and therapeutics. It soon turned out that, due to rapid developments in this field, nothing of the previous volume on Antianginal Drugs by Charlier (Vol. 31, 1971) could be retained apart from its basic idea of devoting considerable space to methodology. Since editors must operate within certain limits, I had to abstain from dealing with acute myocardial infarction in detail despite the well-known overlap between unstable angina, the preinfarction syndrome, and acute myocardial infarction. It was only possible for acute myocardial infarction and the concept of reduction of infarct size to be briefly discussed within the chapter on pathophysiology of acute coronary insufficiency. The chapter on invasive methods provided an opportunity to touch on new approaches to early intervention in acute myocardial infarction. Here, intracoronary streptokinase therapy and PTCA are considered, again with attention to the overlap between mechanical and pharmacological interventions.

Comprehensive Handbook of Psychopathology

Author: Henry E. Adams,Patricia B. Sutker

Publisher: Springer Science & Business Media

ISBN: 0306473771

Category: Psychology

Page: 970

View: 4097

The purpose of this handbook, originally published in 1984, was to provide a compreh- sive review of current clinical descriptions, research , and theories of psychopathology. Descriptive psychopathology is a ?eld that forms the foundation of clinical practice and research in clinical psychology, psychiatry, psychiatric social work, psychiatric nursing, and allied professions in mental health. Since the 1st edition, the editors have devised and updated a handbook to cover both general and speci?c topics in psychopathology that would be useful to researchers, practitioners, and graduate or other advanced students in the mental health and behavioral medicine professions. To implement this plan, we have very carefully chosen colleagues whom we respect for their expertise in particular ?elds. These authors include both clinicians and researchers who have outstanding national reputations, as well as more junior behavioral scientists and clinicians who, in our opinion, will achieve similar recognition in the future. The excellent chapters in this book lead us to believe that we have chosen wisely. We would like to express our appreciation to these authors for their outstanding contributions and cooperation.

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Author: Michelle A. Rudek,Cindy H. Chau,William D. Figg,Howard L. McLeod

Publisher: Springer Science & Business Media

ISBN: 1461491355

Category: Medical

Page: 836

View: 6692

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development