Molecular Imaging I

Author: Wolfhard Semmler,Markus Schwaiger

Publisher: Springer Science & Business Media

ISBN: 3540727183

Category: Medical

Page: 280

View: 1888

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Biomedical Imaging

The Chemistry of Labels, Probes and Contrast Agents

Author: Martin Braddock,David Rotella

Publisher: Royal Society of Chemistry

ISBN: 1849730148

Category: Medical

Page: 533

View: 8910

The focus of this new book is for medicinal chemists on the chemical agents that have been used, or might be required in the future, and the methods of synthesis for inserting the reporter groups. A key reference for academics, postgraduates, researchers, industrialists and professionals working in or joining this field.

MRT in der Gastroenterologie

MRT und bildgebende Differenzialdiagnose ; 29 Tabellen

Author: Henning E. Adamek

Publisher: Georg Thieme Verlag

ISBN: 9783131492913

Category: Gastrointestinale Krankheit - NMR-Tomographie - Lehrbuch

Page: 225

View: 3610


Molecular Imaging II

Author: Wolfhard Semmler,Markus Schwaiger

Publisher: Springer

ISBN: 9783540774495

Category: Medical

Page: 365

View: 3350

The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is beeing addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

Comprehensive Biomedical Physics

Author: N.A

Publisher: Newnes

ISBN: 0444536337

Category: Science

Page: 4056

View: 960

Comprehensive Biomedical Physics is a new reference work that provides the first point of entry to the literature for all scientists interested in biomedical physics. It is of particularly use for graduate and postgraduate students in the areas of medical biophysics. This Work is indispensable to all serious readers in this interdisciplinary area where physics is applied in medicine and biology. Written by leading scientists who have evaluated and summarized the most important methods, principles, technologies and data within the field, Comprehensive Biomedical Physics is a vital addition to the reference libraries of those working within the areas of medical imaging, radiation sources, detectors, biology, safety and therapy, physiology, and pharmacology as well as in the treatment of different clinical conditions and bioinformatics. This Work will be valuable to students working in all aspect of medical biophysics, including medical imaging and biomedical radiation science and therapy, physiology, pharmacology and treatment of clinical conditions and bioinformatics. The most comprehensive work on biomedical physics ever published Covers one of the fastest growing areas in the physical sciences, including interdisciplinary areas ranging from advanced nuclear physics and quantum mechanics through mathematics to molecular biology and medicine Contains 1800 illustrations, all in full color

Grainger & Allison's Diagnostic Radiology E-Book

Author: Andy Adam,Adrian K. Dixon,Jonathan H Gillard,Cornelia Schaefer-Prokop,Ronald G. Grainger,David J. Allison

Publisher: Elsevier Health Sciences

ISBN: 070206128X

Category: Medical

Page: 2144

View: 6638

Effectively apply the latest techniques and approaches with complete updates throughout including 4 new sections (Abdominal Imaging, The Spine, Oncological Imaging, and Interventional Radiology) and 28 brand new chapters. Gain the fresh perspective of two new editors—Jonathan Gillard and Cornelia Schaefer-Prokop -- eight new section editors -- Michael Maher, Andrew Grainger, Philip O’Connor, Rolf Jager, Vicky Goh, Catherine Owens, Anna Maria Belli, Michael Lee -- and 135 new contributors. Stay current with the latest developments in imaging techniques such as CT, MR, ultrasound, and coverage of hot topics such as: Image guided biopsy and ablation techniques and Functional and molecular imaging. Solve even your toughest diagnostic challenges with guidance from nearly 4,000 outstanding illustrations. Quickly grasp the fundamentals you need to know through a more concise, streamlined format.

Handbook of Radiopharmaceuticals

Radiochemistry and Applications

Author: Michael J. Welch

Publisher: John Wiley & Sons

ISBN: 9780471495604

Category: Medical

Page: 848

View: 9142

The Handbook of Radiopharmaceuticals is an up-to-date,authoritative reference that introduces key issues relating to theproduction and application of radiopharmaceuticals. The book coversa wide range of radiochemistry and clinical applications includingthe production of various radionuclides, positron emissiontomography (PET) and drug development. Discussions on the uses ofradiopharmaceuticals in the diagnosis and therapy of cancer andother diseases are also included. Features include: * 28 Chapters contributed by world-renowned experts in thefield * All aspects of radiopharmaceutical production and applicationsare discussed Written by internationally recognised authors, the Handbook ofRadiopharmaceuticals is an invaluable resource for advancedgraduates and researchers within radiochemistry, analytical andorganic chemistry, drug delivery and pharmacokinetics, biochemistryand pharmacology. This book will also be of interest to clinicians,radiologists and radiographers involved in nuclear medicine andradiology. Radiopharmaceuticals are being increasingly utilized assurrogate markers in drug evaluations. This book will be useful toscientists involved in drug development.

Magnetresonanzbildgebung

Theorie und Praxis

Author: Marinus T. Vlaardingerbroek,Jacques A. Boer

Publisher: Springer-Verlag

ISBN: 3642186971

Category: Science

Page: 535

View: 1417

Das bekannte Lehrbuch zur Physik und Technik der kernmagnetischen Resonanz liegt jetzt auch in deutscher Sprache vor. Es beschreibt den physikalischen Hintergrund der Scan-Methoden und ihren Einsatz in der medizinischen Diagnostik. In diesem Zusammenhang werden auch neue Wege und Verfahren aufgezeigt. Besondere Aufmerksamkeit gilt der Behandlung von Artefakten und ihrer mathematischen Beschreibung. Das Buch ist mit vielen Illustrationen zu Scan-Verfahren, wie z.B. RARE, GRASE, EPI, Balanced FFE und Spiralscan ausgestattet. Detaillierte Aussagen über Echoamplituden in Multi-Echosequenzen, wie TSE, FFE und BURST sind in einem besonderen Kapitel mit Hilfe der Konfigurationstheorie ausführlich abgehandelt. Eine kurze Einführung in die Geschichte der MR-Bildgebung rundet dieses Buch ab.

Handbook of Cannabis

Author: Roger Pertwee

Publisher: OUP Oxford

ISBN: 0191639702

Category: Medical

Page: 632

View: 7368

Truly global in scope and with contributions from leading researchers around the world, The Handbook of Cannabis is the definitive resource on this fascinating drug. Combining scientific perspectives and clinical applications, it covers a vast array of topics, from why over the centuries cannabis has been used as a medicine, through the regulations facing those wishing to self-administer cannabis or provide cannabis-based medicines, to the chemical structure of its many constituents and the rapidly growing group of synthetic cannabinoids that are currently being used for 'legal highs'. With each chapter written by a group of one or more internationally recognised subject experts, it provides academics and researchers with authoritative scientific material on the main pharmacological actions and their effects, as well as their pharmacokinetics, metabolism, and forensic detection. In addition it also examines the complex morphology, cultivation, harvesting, and processing of cannabis and the ways in which the plant's chemical composition can be controlled. As well as offering a raft of scientific information there is extensive coverage of cannabinoid-based medicines. Helping readers to identify and evaluate their benefits, chapters explore pharmacological actions and the effects that seem to underlie approved therapeutic uses, how they are currently used to treat certain disorders, and the ever-growing number of wide-ranging potential clinical applications. There is also coverage of both the legal and illegal sources of cannabis, including 'coffee shops' and 'cannabis dispensaries'. The complex issue of 'recreational cannabis' is also tackled. The sought-after and adverse psychological and non-psychological effects are described and discussions are included on how some adverse effects can be lessened by at least one constituent of cannabis, and that it might be possible to reduce the harm that cannabis does to some by changing current regulatory policies. The Handbook of Cannabis is a one-stop reference; essential reading for all clinicians, pharmacologists, psychologists, and psychiatrists interested in this drug, as well as those working in the field of public health.

Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology

Author: Saura C. Sahu,Daniel A. Casciano

Publisher: John Wiley & Sons

ISBN: 1118855868

Category: Science

Page: 440

View: 5746

The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.

CNS Injuries

Cellular Responses and Pharmacological Strategies

Author: Martin Berry,Ann Logan

Publisher: CRC Press

ISBN: 9781420048544

Category: Medical

Page: 240

View: 5216

The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date examination of new developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including inflammatory and immune reactions scarring neuron death demyelination and remyelination axonal regeneration re-establishment of neuronal connectivity Providing a record of recent advances that will help point the way to future developments, this enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including: neurology, pharmacology, pathology, toxicology, immunology, and many others.

Drug Discovery and Development - E-Book

Technology in Transition

Author: Raymond G Hill

Publisher: Elsevier Health Sciences

ISBN: 0702053163

Category: Medical

Page: 368

View: 4839

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Comprehensive Handbook of Psychopathology

Author: Henry E. Adams,Patricia B. Sutker

Publisher: Springer Science & Business Media

ISBN: 0306473771

Category: Psychology

Page: 970

View: 9627

The purpose of this handbook, originally published in 1984, was to provide a compreh- sive review of current clinical descriptions, research , and theories of psychopathology. Descriptive psychopathology is a ?eld that forms the foundation of clinical practice and research in clinical psychology, psychiatry, psychiatric social work, psychiatric nursing, and allied professions in mental health. Since the 1st edition, the editors have devised and updated a handbook to cover both general and speci?c topics in psychopathology that would be useful to researchers, practitioners, and graduate or other advanced students in the mental health and behavioral medicine professions. To implement this plan, we have very carefully chosen colleagues whom we respect for their expertise in particular ?elds. These authors include both clinicians and researchers who have outstanding national reputations, as well as more junior behavioral scientists and clinicians who, in our opinion, will achieve similar recognition in the future. The excellent chapters in this book lead us to believe that we have chosen wisely. We would like to express our appreciation to these authors for their outstanding contributions and cooperation.

Handbook of Medical Imaging

Processing and Analysis Management

Author: N.A

Publisher: Academic Press

ISBN: 9780080533100

Category: Technology & Engineering

Page: 901

View: 8259

In recent years, the remarkable advances in medical imaging instruments have increased their use considerably for diagnostics as well as planning and follow-up of treatment. Emerging from the fields of radiology, medical physics and engineering, medical imaging no longer simply deals with the technology and interpretation of radiographic images. The limitless possibilities presented by computer science and technology, coupled with engineering advances in signal processing, optics and nuclear medicine have created the vastly expanded field of medical imaging. The Handbook of Medical Imaging is the first comprehensive compilation of the concepts and techniques used to analyze and manipulate medical images after they have been generated or digitized. The Handbook is organized in six sections that relate to the main functions needed for processing: enhancement, segmentation, quantification, registration, visualization as well as compression storage and telemedicine. * Internationally renowned authors(Johns Hopkins, Harvard, UCLA, Yale, Columbia, UCSF) * Includes imaging and visualization * Contains over 60 pages of stunning, four-color images

PET/CT-Atlas

Ein interdisziplinärer Leitfaden der onkologischen PET/CT-Diagnostik

Author: Wolfgang Mohnike,Gustav Hör,Heinrich Schelbert

Publisher: Springer-Verlag

ISBN: 3540312153

Category: Medical

Page: 516

View: 7915

Synthese aus praxisrelevanten Informationen, beruhend auf eigenen Erfahrungen, kombiniert mit Literatur- und Studiendaten. Einmalig im deutschsprachigen Raum: Dieses Werk ermöglicht Praktikern, Lehrenden, Lernenden und interessierten Betroffenen den fundierten Einblick in die diagnostischen Möglichkeiten der PET/CT. Mit umfangreicher ausgewählter Fachliteratur, geeignet als Nachschlagewerk und Lehrbuch. Dieser Atlas bietet Orientierung über das einzigartige bildgebende Diagnoseverfahren - basierend auf dem Stoffwechsel der Krebszelle. Plus: CD-ROM mit noch mehr PET/CT-Bildern und vollständiger Bibliographie der ca. 15.000 Literaturstellen.

Handbook of Targeted Delivery of Imaging Agents

Author: Vladimir P. Torchilin

Publisher: CRC Press

ISBN: 9780849383083

Category: Medical

Page: 752

View: 9439

This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Clinical Nuclear Cardiology: State of the Art and Future Directions E-Book

Author: Barry L. Zaret,George A. Beller

Publisher: Elsevier Health Sciences

ISBN: 0323085725

Category: Medical

Page: 896

View: 8507

Clinical Nuclear Cardiology—now in its fourth edition—covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters—Digital/Fast SPECT, Imaging in Revascularized Patients, and more—this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at expertconsult.com includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text. Includes access to the fully searchable contents of the book online at expertconsult.com, along with highly illustrated case studies that let you see the problem using a variety of imaging modalities. Features 20 new chapters including Cellular Mechanisms of Tracer Uptake and Clearance; Attenuation/Scatter Corrections: Clinical Aspects; Hybrid Imaging; Digital/Fast SPECT; Imaging in Revascularized Patients; and more. Focuses on perfusion imaging in a section dedicated to this hot topic so you get all the information you need to stay current.

Handbook of Pediatric Neuropsychology

Author: Andrew S. Davis, PhD,Rik Carl D'Amato

Publisher: Springer Publishing Company

ISBN: 9780826157379

Category: Psychology

Page: 1400

View: 9234

ìBy far, the most comprehensive and detailed coverage of pediatric neuropsychology available in a single book today, Davis provides coverage of basic principles of pediatric neuropsychology, but overall the work highlights applications to daily practice and special problems encountered by the pediatric neuropsychologist.î Cecil R. Reynolds, PhD Texas A&M University "The breadth and depth of this body of work is impressive. Chapters written by some of the best researchers and authors in the field of pediatric neuropsychology address every possible perspective on brain-behavior relationships culminating in an encyclopedic textÖ. This [book] reflects how far and wide pediatric neuropsychology has come in the past 20 years and the promise of how far it will go in the next." Elaine Fletcher-Janzen, EdD, NCSP, ABPdN The Chicago School of Professional Psychology "...it would be hard to imagine a clinical situation in pediatric neuropsychology in whichthis book would fail as a valuable resource."--Archives of Clinical Neuropsychology "I believe there is much to recommend this hefty volume. It is a solid reference that I can see appreciating as a resource as I update my training bibliography."--Journal of the International Neuropsychological Society This landmark reference covers all aspects of pediatric neuropsychology from a research-based perspective, while presenting an applied focus with practical suggestions and guidelines for clinical practice. Useful both as a training manual for graduate students and as a comprehensive reference for experienced practitioners, it is an essential resource for those dealing with a pediatric population. This handbook provides an extensive overview of the most common medical conditions that neuropsychologists encounter while dealing with pediatric populations. It also discusses school-based issues such as special education law, consulting with school staff, and reintegrating children back into mainstream schools. It contains over 100 well-respected authors who are leading researchers in their respective fields. Additionally, each of the 95 chapters includes an up-to-date review of available research, resulting in the most comprehensive text on pediatric neuropsychology available in a single volume. Key Features: Provides thorough information on understanding functional neuroanatomy and development, and on using functional neuroimaging Highlights clinical practice issues, such as legal and ethical decision-making, dealing with child abuse and neglect, and working with school staff Describes a variety of professional issues that neuropsychologists must confront during their daily practice, such as ethics, multiculturalism, child abuse, forensics, and psychopharmacology