Mathematical Models in Biology

Author: Leah Edelstein-Keshet

Publisher: SIAM

ISBN: 9780898719147

Category: Biology

Page: 586

View: 6465

Mathematical Models in Biology is an introductory book for readers interested in biological applications of mathematics and modeling in biology. A favorite in the mathematical biology community, it shows how relatively simple mathematics can be applied to a variety of models to draw interesting conclusions. Connections are made between diverse biological examples linked by common mathematical themes. A variety of discrete and continuous ordinary and partial differential equation models are explored. Although great advances have taken place in many of the topics covered, the simple lessons contained in this book are still important and informative. Audience: the book does not assume too much background knowledge--essentially some calculus and high-school algebra. It was originally written with third- and fourth-year undergraduate mathematical-biology majors in mind; however, it was picked up by beginning graduate students as well as researchers in math (and some in biology) who wanted to learn about this field.

Mathematical Biology

Author: James D. Murray

Publisher: Springer Science & Business Media

ISBN: 3662085429

Category: Mathematics

Page: 770

View: 5665

Mathematics has always benefited from its involvement with developing sciences. Each successive interaction revitalises and enhances the field. Biomedical science is clearly the premier science of the foreseeable future. For the continuing health of their subject mathematicians must become involved with biology. With the example of how mathematics has benefited from and influenced physics, it is clear that if mathematicians do not become involved in the biosciences they will simply not be a part of what are likely to be the most important and exciting scientific discoveries of all time. Mathematical biology is a fast growing, well recognised, albeit not clearly defined, subject and is, to my mind, the most exciting modern application of mathematics. The increasing use of mathematics in biology is inevitable as biol ogy becomes more quantitative. The complexity of the biological sciences makes interdisciplinary involvement essential. For the mathematician, biology opens up new and exciting branches while for the biologist mathematical modelling offers another research tool commmensurate with a new powerful laboratory technique but only if used appropriately and its limitations recognised. However, the use of esoteric mathematics arrogantly applied to biological problems by mathemati cians who know little about the real biology, together with unsubstantiated claims as to how important such theories are, does little to promote the interdisciplinary involvement which is so essential. Mathematical biology research, to be useful and interesting, must be relevant biologically.

Dynamic Models in Biology

Author: Stephen P. Ellner,John Guckenheimer

Publisher: Princeton University Press

ISBN: 1400840961

Category: Science

Page: 352

View: 5677

From controlling disease outbreaks to predicting heart attacks, dynamic models are increasingly crucial for understanding biological processes. Many universities are starting undergraduate programs in computational biology to introduce students to this rapidly growing field. In Dynamic Models in Biology, the first text on dynamic models specifically written for undergraduate students in the biological sciences, ecologist Stephen Ellner and mathematician John Guckenheimer teach students how to understand, build, and use dynamic models in biology. Developed from a course taught by Ellner and Guckenheimer at Cornell University, the book is organized around biological applications, with mathematics and computing developed through case studies at the molecular, cellular, and population levels. The authors cover both simple analytic models--the sort usually found in mathematical biology texts--and the complex computational models now used by both biologists and mathematicians. Linked to a Web site with computer-lab materials and exercises, Dynamic Models in Biology is a major new introduction to dynamic models for students in the biological sciences, mathematics, and engineering.

A Biologist's Guide to Mathematical Modeling in Ecology and Evolution

Author: Sarah P. Otto,Troy Day

Publisher: Princeton University Press

ISBN: 1400840910

Category: Science

Page: 744

View: 6618

Thirty years ago, biologists could get by with a rudimentary grasp of mathematics and modeling. Not so today. In seeking to answer fundamental questions about how biological systems function and change over time, the modern biologist is as likely to rely on sophisticated mathematical and computer-based models as traditional fieldwork. In this book, Sarah Otto and Troy Day provide biology students with the tools necessary to both interpret models and to build their own. The book starts at an elementary level of mathematical modeling, assuming that the reader has had high school mathematics and first-year calculus. Otto and Day then gradually build in depth and complexity, from classic models in ecology and evolution to more intricate class-structured and probabilistic models. The authors provide primers with instructive exercises to introduce readers to the more advanced subjects of linear algebra and probability theory. Through examples, they describe how models have been used to understand such topics as the spread of HIV, chaos, the age structure of a country, speciation, and extinction. Ecologists and evolutionary biologists today need enough mathematical training to be able to assess the power and limits of biological models and to develop theories and models themselves. This innovative book will be an indispensable guide to the world of mathematical models for the next generation of biologists. A how-to guide for developing new mathematical models in biology Provides step-by-step recipes for constructing and analyzing models Interesting biological applications Explores classical models in ecology and evolution Questions at the end of every chapter Primers cover important mathematical topics Exercises with answers Appendixes summarize useful rules Labs and advanced material available

A Course in Mathematical Biology

Quantitative Modeling with Mathematical and Computational Methods

Author: Gerda de Vries,Thomas Hillen,Mark Lewis,Johannes Mller,Birgitt SchÓnfisch

Publisher: SIAM

ISBN: 0898718252

Category: Mathematics

Page: 309

View: 452

This is the only book that teaches all aspects of modern mathematical modeling and that is specifically designed to introduce undergraduate students to problem solving in the context of biology. Included is an integrated package of theoretical modeling and analysis tools, computational modeling techniques, and parameter estimation and model validation methods, with a focus on integrating analytical and computational tools in the modeling of biological processes. Divided into three parts, it covers basic analytical modeling techniques; introduces computational tools used in the modeling of biological problems; and includes various problems from epidemiology, ecology, and physiology. All chapters include realistic biological examples, including many exercises related to biological questions. In addition, 25 open-ended research projects are provided, suitable for students. An accompanying Web site contains solutions and a tutorial for the implementation of the computational modeling techniques. Calculations can be done in modern computing languages such as Maple, Mathematica, and MATLAB?.

Essential Mathematical Biology

Author: Nicholas F. Britton

Publisher: Springer Science & Business Media

ISBN: 1447100492

Category: Mathematics

Page: 335

View: 5283

This self-contained introduction to the fast-growing field of Mathematical Biology is written for students with a mathematical background. It sets the subject in a historical context and guides the reader towards questions of current research interest. A broad range of topics is covered including: Population dynamics, Infectious diseases, Population genetics and evolution, Dispersal, Molecular and cellular biology, Pattern formation, and Cancer modelling. Particular attention is paid to situations where the simple assumptions of homogenity made in early models break down and the process of mathematical modelling is seen in action.

Mathematical Models in Biology

An Introduction

Author: Elizabeth S. Allman,John A. Rhodes

Publisher: Cambridge University Press

ISBN: 9780521525862

Category: Mathematics

Page: 370

View: 5950

Linear and non-linear models of populations, molecular evolution, phylogenetic tree construction, genetics, and infectious diseases are presented with minimal prerequisites.

Introduction to the Foundations of Applied Mathematics

Author: Mark H. Holmes

Publisher: Springer Science & Business Media

ISBN: 0387877657

Category: Mathematics

Page: 468

View: 7241

FOAM. This acronym has been used for over ?fty years at Rensselaer to designate an upper-division course entitled, Foundations of Applied Ma- ematics. This course was started by George Handelman in 1956, when he came to Rensselaer from the Carnegie Institute of Technology. His objective was to closely integrate mathematical and physical reasoning, and in the p- cess enable students to obtain a qualitative understanding of the world we live in. FOAM was soon taken over by a young faculty member, Lee Segel. About this time a similar course, Introduction to Applied Mathematics, was introduced by Chia-Ch’iao Lin at the Massachusetts Institute of Technology. Together Lin and Segel, with help from Handelman, produced one of the landmark textbooks in applied mathematics, Mathematics Applied to - terministic Problems in the Natural Sciences. This was originally published in 1974, and republished in 1988 by the Society for Industrial and Applied Mathematics, in their Classics Series. This textbook comes from the author teaching FOAM over the last few years. In this sense, it is an updated version of the Lin and Segel textbook.

Mathematical Models

Mechanical Vibrations, Population Dynamics, and Traffic Flow

Author: Richard Haberman

Publisher: SIAM

ISBN: 0898714087

Category: Mathematics

Page: 402

View: 2609

The author uses mathematical techniques to give an in-depth look at models for mechanical vibrations, population dynamics, and traffic flow.

Mathematics in Medicine and the Life Sciences

Author: Frank C. Hoppensteadt,Charles Peskin

Publisher: Springer Science & Business Media

ISBN: 1475741316

Category: Mathematics

Page: 252

View: 6089

The aim of this book is to introduce the subject of mathematical modeling in the life sciences. It is intended for students of mathematics, the physical sciences, and engineering who are curious about biology. Additionally, it will be useful to students of the life sciences and medicine who are unsatisfied with mere description and who seek an understanding of biological mechanism and dynamics through the use of mathematics. The book will be particularly useful to premedical students, because it will introduce them not only to a collection of mathematical methods but also to an assortment of phenomena involving genetics, epidemics, and the physiology of the heart, lung, and kidney. Because of its introductory character, mathematical prerequisites are kept to a minimum; they involve only what is usually covered in the first semester of a calculus sequence. The authors have drawn on their extensive experience as modelers to select examples which are simple enough to be understood at this elementary level and yet realistic enough to capture the essence of significant biological phenomena drawn from the areas of population dynamics and physiology. Because the models presented are realistic, the book can serve not only as an introduction to mathematical methods but also as a mathematical introduction to the biological material itself. For the student, who enjoys mathematics, such an introduction will be far more stimulating and satisfying than the purely descriptive approach that is traditional in the biological sciences.

Nonlinear Dynamics in Physiology and Medicine

Author: Anne Beuter,Leon Glass,Michael C. Mackey,Michele S. Titcombe

Publisher: Springer Science & Business Media

ISBN: 0387216405

Category: Mathematics

Page: 436

View: 9079

Introduces concepts from nonlinear dynamics using an almost exclusively biological setting for motivation, and includes examples of how these concepts are used in experimental investigations of biological and physiological systems. One novel feature of the book is the inclusion of classroom-tested computer exercises. This book will appeal to students and researchers working in the natural and physical sciences wanting to learn about physiological systems from a mathematical perspective.

The Nature of Mathematical Modeling

Author: Neil A. Gershenfeld

Publisher: Cambridge University Press

ISBN: 9780521570954

Category: Mathematics

Page: 344

View: 4478

This book first covers exact and approximate analytical techniques (ordinary differential and difference equations, partial differential equations, variational principles, stochastic processes); numerical methods (finite differences for ODE's and PDE's, finite elements, cellular automata); model inference based on observations (function fitting, data transforms, network architectures, search techniques, density estimation); as well as the special role of time in modeling (filtering and state estimation, hidden Markov processes, linear and nonlinear time series). Each of the topics in the book would be the worthy subject of a dedicated text, but only by presenting the material in this way is it possible to make so much material accessible to so many people. Each chapter presents a concise summary of the core results in an area, providing an orientation to what they can (and cannot) do, enough background to use them to solve typical problems, and pointers to access the literature for particular applications.

Mathematics in Nature

Modeling Patterns in the Natural World

Author: John A. Adam

Publisher: Princeton University Press

ISBN: 1400841011

Category: Mathematics

Page: 392

View: 9143

From rainbows, river meanders, and shadows to spider webs, honeycombs, and the markings on animal coats, the visible world is full of patterns that can be described mathematically. Examining such readily observable phenomena, this book introduces readers to the beauty of nature as revealed by mathematics and the beauty of mathematics as revealed in nature. Generously illustrated, written in an informal style, and replete with examples from everyday life, Mathematics in Nature is an excellent and undaunting introduction to the ideas and methods of mathematical modeling. It illustrates how mathematics can be used to formulate and solve puzzles observed in nature and to interpret the solutions. In the process, it teaches such topics as the art of estimation and the effects of scale, particularly what happens as things get bigger. Readers will develop an understanding of the symbiosis that exists between basic scientific principles and their mathematical expressions as well as a deeper appreciation for such natural phenomena as cloud formations, halos and glories, tree heights and leaf patterns, butterfly and moth wings, and even puddles and mud cracks. Developed out of a university course, this book makes an ideal supplemental text for courses in applied mathematics and mathematical modeling. It will also appeal to mathematics educators and enthusiasts at all levels, and is designed so that it can be dipped into at leisure.

An Invitation to Applied Mathematics

Differential Equations, Modeling, and Computation

Author: Carmen Chicone

Publisher: Academic Press

ISBN: 0128041544

Category: Mathematics

Page: 878

View: 3827

An Invitation to Applied Mathematics: Differential Equations, Modeling, and Computation introduces the reader to the methodology of modern applied mathematics in modeling, analysis, and scientific computing with emphasis on the use of ordinary and partial differential equations. Each topic is introduced with an attractive physical problem, where a mathematical model is constructed using physical and constitutive laws arising from the conservation of mass, conservation of momentum, or Maxwell's electrodynamics. Relevant mathematical analysis (which might employ vector calculus, Fourier series, nonlinear ODEs, bifurcation theory, perturbation theory, potential theory, control theory, or probability theory) or scientific computing (which might include Newton's method, the method of lines, finite differences, finite elements, finite volumes, boundary elements, projection methods, smoothed particle hydrodynamics, or Lagrangian methods) is developed in context and used to make physically significant predictions. The target audience is advanced undergraduates (who have at least a working knowledge of vector calculus and linear ordinary differential equations) or beginning graduate students. Readers will gain a solid and exciting introduction to modeling, mathematical analysis, and computation that provides the key ideas and skills needed to enter the wider world of modern applied mathematics. Presents an integrated wealth of modeling, analysis, and numerical methods in one volume Provides practical and comprehensible introductions to complex subjects, for example, conservation laws, CFD, SPH, BEM, and FEM Includes a rich set of applications, with more appealing problems and projects suggested

An Introduction to Mathematical Biology

Author: Linda J. S. Allen

Publisher: Prentice Hall

ISBN: 9780130352163

Category: Mathematics

Page: 348

View: 3437

KEY BENEFIT: This reference introduces a variety of mathematical models for biological systems, and presents the mathematical theory and techniques useful in analyzing those models. Material is organized according to the mathematical theory rather than the biological application. Contains applications of mathematical theory to biological examples in each chapter. Focuses on deterministic mathematical models with an emphasis on predicting the qualitative solution behavior over time. Discusses classical mathematical models from population , including the Leslie matrix model, the Nicholson-Bailey model, and the Lotka-Volterra predator-prey model. Also discusses more recent models, such as a model for the Human Immunodeficiency Virus - HIV and a model for flour beetles. KEY MARKET: Readers seeking a solid background in the mathematics behind modeling in biology and exposure to a wide variety of mathematical models in biology.

Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology

Author: Willem van Meurs

Publisher: McGraw Hill Professional

ISBN: 0071714464

Category: Technology & Engineering

Page: 224

View: 3012

THEORY AND PRACTICE OF MODELING AND SIMULATING HUMAN PHYSIOLOGY Written by a coinventor of the Human Patient Simulator (HPS) and past president of the Society in Europe for Simulation Applied to Medicine (SESAM), Modeling and Simulation in Biomedical Engineering: Applications in Cardiorespiratory Physiology is a compact and consistent introduction to this expanding field. The book divides the modeling and simulation process into five manageable steps--requirements, conceptual models, mathematical models, software implementation, and simulation results and validation. A framework and a basic set of deterministic, continuous-time models for the cardiorespiratory system are provided. This timely resource also addresses advanced topics, including sensitivity analysis and setting model requirements as part of an encompassing simulation and simulator design. Practical examples provide you with the skills to evaluate and adapt existing physiologic models or create new ones for specific applications. Coverage includes: Signals and systems Model requirements Conceptual models Mathematical models Software implementation Simulation results and model validation Cardiorespiratory system model Circulation Respiration Physiologic control Sensitivity analysis of a cardiovascular model Design of model-driven acute care training simulators “Uniquely qualified to author such a text, van Meurs is one of the original developers of CAE Healthcare’s Human Patient Simulator (HPS). ...His understanding of mathematics, human physiology, pharmacology, control systems, and systems engineering, combined with a conversational writing style, results in a readable text. ...The ample illustrations and tables also break up the text and make reading the book easier on the eyes. ...concise yet in conversational style, with real-life examples. This book is highly recommended for coursework in physiologic modeling and for all who are interested in simulator design and development. The book pulls all these topics together under one cover and is an important contribution to biomedical literature.” --IEEE Pulse, January 2014 “This book is written by a professional engineer who is unique in that he seems to have a natural understanding of 3 key areas as follows: the hardware involved with simulators, human physiology, and mathematical modeling. Willem van Meurs is one of the inventors of the model-driven human patient simulator (HPS), and so, he is very qualified to write this book. The book is written in a clear way, using the first person throughout, in a conversational manner, with a style that involves posing questions and answering them in subsequent text. ...The book starts with a very useful introduction and background chapter, setting out the scene for the rest of the book. ...I have used his book in enhancing my own talks and understanding human patient simulation and can strongly recommend it.” --Simulation in Healthcare December, 2012 Reviewed by Mark A. Tooley, Ph.D., Department of Medical Physics and Bioengineering, Royal United Hospital, Combe Park, Bath, UK.

Applied Mathematical Models in Human Physiology

Author: Johnny T. Ottesen,Mette S. Olufsen,Jesper K. Larsen

Publisher: SIAM

ISBN: 9780898718287

Category: Body fluids

Page: 298

View: 3784

This book introduces mathematicians to real applications from physiology. Using mathematics to analyze physiological systems, the authors focus on models reflecting current research in cardiovascular and pulmonary physiology. In particular, they present models describing blood flow in the heart and the cardiovascular system, as well as the transport of oxygen and carbon dioxide through the respiratory system and a model for baroreceptor regulation.

Mathematical Biology

An Introduction with Maple and Matlab

Author: Ronald W. Shonkwiler,James Herod

Publisher: Springer Science & Business Media

ISBN: 0387709843

Category: Science

Page: 551

View: 9569

This text presents mathematical biology as a field with a unity of its own, rather than only the intrusion of one science into another. The book focuses on problems of contemporary interest, such as cancer, genetics, and the rapidly growing field of genomics.