Tells the story of human development from egg to adult, showing how the understanding of how human beings come to be has been transformed in recent years.
How the Human Body Creates Itself
Author: Jamie A. Davies
Publisher: Oxford University Press
Where did I come from? Why do I have two arms but just one head? How is my left leg the same size as my right one? Why are the fingerprints of identical twins not identical? How did my brain learn to learn? Why must I die? Questions like these remain biology's deepest and most ancient challenges. They force us to confront a fundamental biological problem: how can something as large and complex as a human body organize itself from the simplicity of a fertilized egg? A convergence of ideas from embryology, genetics, physics, networks, and control theory has begun to provide real answers. Based on the central principle of 'adaptive self-organization', it explains how the interactions of many cells, and of the tiny molecular machines that run them, can organize tissue structures vastly larger than themselves, correcting errors as they go along and creating new layers of complexity where there were none before. Life Unfolding tells the story of human development from egg to adult, from this perspective, showing how our whole understanding of how we come to be has been transformed in recent years. Highlighting how embryological knowledge is being used to understand why bodies age and fail, Jamie A. Davies explores the profound and fascinating impacts of our newfound knowledge.
How the human body creates itself
Author: Jamie A. Davies
Publisher: OUP Oxford
Seventy years ago, Erwin Schrodinger posed a profound question: 'What is life, and how did it emerge from non-life?' This problem has puzzled biologists and physical scientists ever since. Living things are hugely complex and have unique properties, such as self-maintenance and apparently purposeful behaviour which we do not see in inert matter. So how does chemistry give rise to biology? What could have led the first replicating molecules up such a path? Now, developments in the emerging field of 'systems chemistry' are unlocking the problem. Addy Pross shows how the different kind of stability that operates among replicating molecules results in a tendency for chemical systems to become more complex and acquire the properties of life. Strikingly, he demonstrates that Darwinian evolution is the biological expression of a deeper, well-defined chemical concept: the whole story from replicating molecules to complex life is one continuous process governed by an underlying physical principle. The gulf between biology and the physical sciences is finally becoming bridged. This new edition includes an Epilogue describing developments in the concepts of fundamental forms of stability discussed in the book, and their profound implications. Oxford Landmark Science books are 'must-read' classics of modern science writing which have crystallized big ideas, and shaped the way we think.
How Chemistry Becomes Biology
Author: Addy Pross
Publisher: Oxford University Press
A physicist describes how life emerges from the random motion of atoms through sophisticated cellular machinery and describes the long quest to determine the true nature of life from ancient Greece to the study of modern nanotechnology. 20,000 first printing.
How Molecular Machines Extract Order from Chaos
Author: Peter M. Hoffmann
Publisher: Basic Books
Oxygen takes the reader on an enthralling journey, as gripping as a thriller, as it unravels the unexpected ways in which oxygen spurred the evolution of life and death. The book explains far more than the size of ancient insects: it shows how oxygen underpins the origin of biological complexity, the birth of photosynthesis, the sudden evolution of animals, the need for two sexes, the accelerated ageing of cloned animals like Dolly the sheep, and the surprisingly long lives of bats and birds. Drawing on this grand evolutionary canvas, Oxygen offers fresh perspectives on our own lives and deaths, explaining modern killer diseases, why we age, and what we can do about it.
The Molecule that Made the World
Author: Nick Lane
Publisher: Oxford University Press, USA
Here's a rich pictorial review of normal and abnormal human prenatal development. For each body system or region, you'll find a brief description of the developmental plan, with key concepts and terminology, followed by discussions of histological principles, the classification of congenital defects, and basic cellular, molecular, and genetic concepts; An emphasis on morphological patterns in the embryo and fetus makes it easy to understand the structure and function of the adult body and the embryonic basis of birth defects. Summary tables and terminology sections at the end of each chapter, plus an appendix with all major congenital defects and their embryonic basis, make it easy to review course material and prepare for the USMLE.
Author: Larry R. Cochard
Publisher: Elsevier Health Sciences
The author, a molecular biologist, uses the relatively new science of quantum mechanics to explain how life originally evolved on the planet. Reprint.
Author: Johnjoe McFadden
Publisher: W. W. Norton & Company
The cell is the basic building block of life. In its 3.5 billion years on the planet, it has proven to be a powerhouse, spreading life first throughout the seas, then across land, developing the rich and complex diversity of life that populates the planet today. With The Cell: A Visual Tour of the Building Block of Life, Jack Challoner treats readers to a visually stunning tour of these remarkable molecular machines. Most of the living things we’re familiar with—the plants in our gardens, the animals we eat—are composed of billions or trillions of cells. Most multicellular organisms consist of many different types of cells, each highly specialized to play a particular role—from building bones or producing the pigment in flower petals to fighting disease or sensing environmental cues. But the great majority of living things on our planet exist as single cell. These cellular singletons are every bit as successful and diverse as multicellular organisms, and our very existence relies on them. The book is an authoritative yet accessible account of what goes on inside every living cell—from building proteins and producing energy to making identical copies of themselves—and the importance of these chemical reactions both on the familiar everyday scale and on the global scale. Along the way, Challoner sheds light on many of the most intriguing questions guiding current scientific research: What special properties make stem cells so promising in the treatment of injury and disease? How and when did single-celled organisms first come together to form multicellular ones? And how might scientists soon be prepared to build on the basic principles of cell biology to build similar living cells from scratch.
A Visual Tour of the Building Block of Life
Author: Jack Challoner
Publisher: University of Chicago Press
Over a decade ago, as the Human Genome Project completed its mapping of the entire human genome, hopes ran high that we would rapidly be able to use our knowledge of human genes to tackle many inherited diseases, and understand what makes us unique among animals. But things didn't turn out that way. For a start, we turned out to have far fewer genes than originally thought -- just over 20,000, the same sort of number as a fruit fly or worm. What's more, the proportion of DNA consisting of genes coding for proteins was a mere 2%. So, was the rest of the genome accumulated 'junk'? Things have changed since those early heady days of the Human Genome Project. But the emerging picture is if anything far more exciting. In this book, John Parrington explains the key features that are coming to light - some, such as the results of the international ENCODE programme, still much debated and controversial in their scope. He gives an outline of the deeper genome, involving layers of regulatory elements controlling and coordinating the switching on and off of genes; the impact of its 3D geometry; the discovery of a variety of new RNAs playing critical roles; the epigenetic changes influenced by the environment and life experiences that can make identical twins different and be passed on to the next generation; and the clues coming out of comparisons with the genomes of Neanderthals as well as that of chimps about the development of our species. We are learning more about ourselves, and about the genetic aspects of many diseases. But in its complexity, flexibility, and ability to respond to environmental cues, the human genome is proving to be far more subtle than we ever imagined.
Why There Is More to the Human Genome Than Meets the Eye
Author: John Parrington
Publisher: Oxford University Press
Category: Human genome
As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.
Author: Bruce Alberts
Publisher: Garland Science
Life is beautiful, ruthless, and very, very strange. In the evolutionary arms race that has raged on since life began, organisms have developed an endless variety of survival strategies. From sharp claws to brute strength, camouflage to venom—all these tools and abilities share one purpose: to keep their bearer alive long enough to reproduce, helping the species avoid extinction. Every living thing on this planet has developed a time-tested arsenal of weapons and defenses. Some of these weapons and defenses, however, are decidedly more unusual than others. In Strange Survivors, biologist Oné R. Pagán takes us on a tour of the improbable, the ingenious, and the just plain bizarre ways that creatures fight for life. Inside this funny, fascinating field guide to nature’s most colorful characters, you’ll meet killer snails, social bacteria, and an animal with toxic elbows. But Strange Survivors is more than a collection of curiosities—it is a love letter to science and an argument for the continuing relevance of this evolutionary battle as we face the threat of resistant bacteria and the need for novel medical therapies. Whether discussing blood-thinning bats and electric fish or pondering the power of cooperation, Pagán reveals the surprising lessons found in some of life’s natural oddities and how the tactics they employ to live might aid our own survival.
How Organisms Attack and Defend in the Game of Life
Author: One R. Pagan
Publisher: BenBella Books
The struggle to understand the infant-parent bond ranks as one of the great quests of modern psychology, one that touches us deeply because it holds so many clues to how we become who we are. How are our personalities formed? How do our early struggles with our parents reappear in the way we relate to others as adults? Why do we repeat with our own children--seemingly against our will--the very behaviors we most disliked about our parents? In Becoming Attached, psychologist and noted journalist Robert Karen offers fresh insight into some of the most fundamental and fascinating questions of emotional life. Karen begins by tracing the history of attachment theory through the controversial work of John Bowlby, a British psychoanalyst, and Mary Ainsworth, an American developmental psychologist, who together launched a revolution in child psychology. Karen tells about their personal and professional struggles, their groundbreaking discoveries, and the recent flowering of attachment theory research in universities all over the world, making it one of the century's most enduring ideas in developmental psychology. In a world of working parents and makeshift day care, the need to assess the impact of parenting styles and the bond between child and caregiver is more urgent than ever. Karen addresses such issues as: What do children need to feel that the world is a positive place and that they have value? Is day care harmful for children under one year? What experiences in infancy will enable a person to develop healthy relationships as an adult?, and he demonstrates how different approaches to mothering are associated with specific infant behaviors, such as clinginess, avoidance, or secure exploration. He shows how these patterns become ingrained and how they reveal themselves at age two, in the preschool years, in middle childhood, and in adulthood. And, with thought-provoking insights, he gives us a new understanding of how negative patterns and insecure attachment can be changed and resolved throughout a person's life. The infant is in many ways a great mystery to us. Every one of us has been one; many of us have lived with or raised them. Becoming Attached is not just a voyage of discovery in child emotional development and its pertinence to adult life but a voyage of personal discovery as well, for it is impossible to read this book without reflecting on one's own life as a child, a parent, and an intimate partner in love or marriage.
First Relationships and how They Shape Our Capacity to Love
Author: Robert Karen
Publisher: Oxford University Press, USA
Category: Family & Relationships
The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work? There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. Figuring out how it all works Â? how your genes build your body Â? is a major challenge for researchers around the world. And what they're discovering is that far from genes being a fixed, deterministic blueprint, things are much more random and wobbly than anyone expected. Drawing on stories ranging from six toed cats and stickleback hips to Mickey Mouse mice and zombie genes Â? told by researchers working at the cutting edge of genetics Â? Kat Arney explores the mysteries in our genomes with clarity, flair and wit, creating a companion reader to the book of life itself.
Understanding how our genes work
Author: Kat Arney
Publisher: Bloomsbury Publishing
You are just 10% human. For every one of the cells that make up the vessel that you call your body, there are nine impostor cells hitching a ride. You are not just flesh and blood, muscle and bone, brain and skin, but also bacteria and fungi. Over your lifetime, you will carry the equivalent weight of five African elephants in microbes. You are not an individual but a colony. Until recently, we had thought our microbes hardly mattered, but science is revealing a different story, one in which microbes run our bodies and becoming a healthy human is impossible without them. In this riveting, shocking, and beautifully written book, biologist Alanna Collen draws on the latest scientific research to show how our personal colony of microbes influences our weight, our immune system, our mental health, and even our choice of partner. She argues that so many of our modern diseases—obesity, autism, mental illness, digestive disorders, allergies, autoimmunity afflictions, and even cancer—have their root in our failure to cherish our most fundamental and enduring relationship: that with our personal colony of microbes. Many of the questions about modern diseases left unanswered by the Human Genome Project are illuminated by this new science. And the good news is that unlike our human cells, we can change our microbes for the better. Collen's book is a revelatory and indispensable guide. It is science writing at its most relevant: life—and your body—will never seem the same again.
How Your Body's Microbes Hold the Key to Health and Happiness
Author: Alanna Collen
"This is a clear and engagingly written book," declared Nature, "recommended certainly to nonspecialists, but also to developmental biologists." Its exploration of how single cells multiply and develop offers an accessible look at a difficult subject. Easy-to-understand descriptions of experimental studies offer fascinating insights into aging, cancer, regeneration, and evolution. 1993 edition.
Author: Lewis Wolpert
Publisher: Courier Corporation
From the author of the acclaimed The Epigenetics Revolution (‘A book that would have had Darwin swooning’ – Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions – 98% of the human genome – were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself – and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.
A Journey Through the Dark Matter of the Genome
Author: Nessa Carey
Publisher: Icon Books
This third book by award-winning executive, leadership, and life coach Andria Corso takes you on her journey from grief and fear to life's natural, Divine flow. If you find it hard to trust that the dots will connect in your life and that everything will work out, Fear to Flow will show you how to identify your false fears and move through the F.L.O.W. steps of Feeling, Listening, Offering, and Witnessing to emerge flowing with Freedom, Love, Openness, and Wonder. Learn how to leave your struggles behind and allow life to unfold peacefully, joyfully, perfectly. Fall in love with your life, along with Andria, in this heartwarming journey to living in the flow.
How to Give Up Your Struggle and Allow Life to Unfold Perfectly
Author: Andria Corso
Publisher: Andriacorso & Company
In this multi-award-winning, bestselling novel, Margaret Atwood has created a stunning Orwellian vision of the near future. This is the story of Offred, one of the unfortunate “Handmaids” under the new social order who have only one purpose: to breed. In Gilead, where women are prohibited from holding jobs, reading, and forming friendships, Offred’s persistent memories of life in the “time before” and her will to survive are acts of rebellion. Provocative, startling, prophetic, and with Margaret Atwood’s devastating irony, wit, and acute perceptive powers in full force, The Handmaid’s Tale is at once a mordant satire and a dire warning.
Author: Margaret Atwood
Publisher: Emblem Editions