Introduction to Experimental Biophysics, Second Edition

Biological Methods for Physical Scientists

Author: Jay L. Nadeau,Jay Nadeau

Publisher: CRC Press

ISBN: 1317974522

Category: Medical

Page: 764

View: 1007

Praise for the First Edition “essential reading for any physical scientist who is interested in performing biological research.” ?Contemporary Physics "an ambitious text.... Each chapter contains protocols and the conceptual reasoning behind them, which is often useful to physicists performing biological experiments for the first time." –Physics Today This fully updated and expanded text is the best starting point for any student or researcher in the physical sciences to gain firm grounding in the techniques employed in molecular biophysics and quantitative biology. It includes brand new chapters on gene expression techniques, advanced techniques in biological light microscopy (super-resolution, two-photon, and fluorescence lifetime imaging), holography, and gold nanoparticles used in medicine. The author shares invaluable practical tips and insider’s knowledge to simplify potentially confusing techniques. The reader is guided through easy-to-follow examples carried out from start to finish with practical tips and insider’s knowledge. The emphasis is on building comfort with getting hands "wet" with basic methods and finally understanding when and how to apply or adapt them to address different questions. Jay L. Nadeau is a scientific researcher and head of the Biomedical Engineering in Advanced Applications of Quantum, Oscillatory, and Nanotechnological Systems (BEAAQONS) lab at Caltech and was previously associate professor of biomedical engineering and physics at McGill University.

Quantitative Understanding of Biosystems

An Introduction to Biophysics, Second Edition

Author: Thomas M. Nordlund,Peter M. Hoffmann

Publisher: CRC Press

ISBN: 1351801171

Category: Science

Page: 608

View: 486

Praise for the prior edition "The author has done a magnificent job... this book is highly recommended for introducing biophysics to the motivated and curious undergraduate student." ―Contemporary Physics "a terrific text ... will enable students to understand the significance of biological parameters through quantitative examples―a modern way of learning biophysics." ―American Journal of Physics "A superb pedagogical textbook... Full-color illustrations aid students in their understanding" ―Midwest Book Review This new edition provides a complete update to the most accessible yet thorough introduction to the physical and quantitative aspects of biological systems and processes involving macromolecules, subcellular structures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and computational tools. The authors have also incorporated additions to the multimedia component of video clips and animations, as well as interactive diagrams and graphs. Thomas Nordlund is professor emeritus in the Department of Physics at The University of Alabama at Birmingham. He is an elected fellow of the American Physical Society and has been studying biomolecular dynamics for over thirty years. Peter M. Hoffmann is a professor in the Department of Physics and Astronomy at Wayne State University in Detroit, Michigan, where he founded the biomedical physics program. He has been involved in soft matter and biophysics research for twenty-five years, and earned his PhD in materials science and engineering from Johns Hopkins University.

Systems Immunology

An Introduction to Modeling Methods for Scientists

Author: Jayajit Das,Ciriyam Jayaprakash

Publisher: CRC Press

ISBN: 1498717411

Category: Mathematics

Page: 334

View: 645

"Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.

Mass Spectrometry in Structural Biology and Biophysics

Architecture, Dynamics, and Interaction of Biomolecules

Author: Igor A. Kaltashov,Stephen J. Eyles

Publisher: John Wiley & Sons

ISBN: 0470937793

Category: Medical

Page: 289

View: 2553

With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and a brief overview of traditional biophysical techniques before outlining the more advanced concepts of mass spectrometry. The new edition gives an up-to-date and expanded coverage of experimental methodologies and a clear look at MS-based methods for studying higher order structures and biopolymers. A must for researchers in the field of biophysics, structural biology, and protein chemistry.

Quantitative Understanding of Biosystems

An Introduction to Biophysics, Second Edition

Author: Thomas Nordlund,Peter M. Hoffmann

Publisher: CRC Press

ISBN: 9781138633414

Category: Biophysics

Page: 608

View: 431

Praise for the prior edition "The author has done a magnificent job... this book is highly recommended for introducing biophysics to the motivated and curious undergraduate student." ―Contemporary Physics "a terrific text ... will enable students to understand the significance of biological parameters through quantitative examples―a modern way of learning biophysics." ―American Journal of Physics "A superb pedagogical textbook... Full-color illustrations aid students in their understanding" ―Midwest Book Review This new edition provides a complete update to the most accessible yet thorough introduction to the physical and quantitative aspects of biological systems and processes involving macromolecules, subcellular structures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and computational tools. The authors have also incorporated additions to the multimedia component of video clips and animations, as well as interactive diagrams and graphs. Thomas Nordlund is professor emeritus in the Department of Physics at The University of Alabama at Birmingham. He is an elected fellow of the American Physical Society and has been studying biomolecular dynamics for over thirty years. Peter M. Hoffmann is a professor in the Department of Physics and Astronomy at Wayne State University in Detroit, Michigan, where he founded the biomedical physics program. He has been involved in soft matter and biophysics research for twenty-five years, and earned his PhD in materials science and engineering from Johns Hopkins University. ures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and computational tools. The authors have also incorporated additions to the multimedia component of video clips and animations, as well as interactive diagrams and graphs. Thomas Nordlund is professor emeritus in the Department of Physics at The University of Alabama at Birmingham. He is an elected fellow of the American Physical Society and has been studying biomolecular dynamics for over thirty years. Peter M. Hoffmann is a professor in the Department of Physics and Astronomy at Wayne State University in Detroit, Michigan, where he founded the biomedical physics program. He has been involved in soft matter and biophysics research for twenty-five years, and earned his PhD in materials science and engineering from Johns Hopkins University. Hopkins University.

The Physics of Proteins

An Introduction to Biological Physics and Molecular Biophysics

Author: Hans Frauenfelder

Publisher: Springer Science & Business Media

ISBN: 9781441910448

Category: Science

Page: 448

View: 5612

Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding

From Molecules to Networks

An Introduction to Cellular and Molecular Neuroscience

Author: Ruth Heidelberger,M. Neal Waxham,John H. Byrne,James L. Roberts

Publisher: Academic Press

ISBN: 9780080920832

Category: Science

Page: 656

View: 1321

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. • Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook • Discusses emerging new understanding of non-classical molecules that affect neuronal signaling • Full colour, professional graphics throughout • Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease.

Compiler

Prinzipien, Techniken und Werkzeuge

Author: Alfred V. Aho

Publisher: Pearson Deutschland GmbH

ISBN: 9783827370976

Category: Compiler

Page: 1253

View: 2408


Bioinformatics

A Practical Guide to the Analysis of Genes and Proteins

Author: Andreas D. Baxevanis,B. F. Francis Ouellette

Publisher: John Wiley & Sons

ISBN: 0471461016

Category: Computers

Page: 504

View: 3603

"In this book, Andy Baxevanis and Francis Ouellette . . . haveundertaken the difficult task of organizing the knowledge in thisfield in a logical progression and presenting it in a digestibleform. And they have done an excellent job. This fine text will makea major impact on biological research and, in turn, on progress inbiomedicine. We are all in their debt." —Eric Lander from the Foreword Reviews from the First Edition "...provides a broad overview of the basic tools for sequenceanalysis ... For biologists approaching this subject for the firsttime, it will be a very useful handbook to keep on the shelf afterthe first reading, close to the computer." —Nature Structural Biology "...should be in the personal library of any biologist who usesthe Internet for the analysis of DNA and protein sequencedata." —Science "...a wonderful primer designed to navigate the novice throughthe intricacies of in scripto analysis ... The accomplished genesearcher will also find this book a useful addition to theirlibrary ... an excellent reference to the principles ofbioinformatics." —Trends in Biochemical Sciences This new edition of the highly successful Bioinformatics:A Practical Guide to the Analysis of Genes and Proteinsprovides a sound foundation of basic concepts, with practicaldiscussions and comparisons of both computational tools anddatabases relevant to biological research. Equipping biologists with the modern tools necessary to solvepractical problems in sequence data analysis, the Second Editioncovers the broad spectrum of topics in bioinformatics, ranging fromInternet concepts to predictive algorithms used on sequence,structure, and expression data. With chapters written by experts inthe field, this up-to-date reference thoroughly covers vitalconcepts and is appropriate for both the novice and the experiencedpractitioner. Written in clear, simple language, the book isaccessible to users without an advanced mathematical or computerscience background. This new edition includes: All new end-of-chapter Web resources, bibliographies, andproblem sets Accompanying Web site containing the answers to the problems,as well as links to relevant Web resources New coverage of comparative genomics, large-scale genomeanalysis, sequence assembly, and expressed sequence tags A glossary of commonly used terms in bioinformatics andgenomics Bioinformatics: A Practical Guide to the Analysis of Genesand Proteins, Second Edition is essential reading forresearchers, instructors, and students of all levels in molecularbiology and bioinformatics, as well as for investigators involvedin genomics, positional cloning, clinical research, andcomputational biology.

Biophysik

Eine Einführung

Author: Rodney Cotterill

Publisher: John Wiley & Sons

ISBN: 9783527406869

Category: Biophysics

Page: 395

View: 4657

Was eignet sich besser zum Einstieg in ein neues Fachgebiet als ein in der Muttersprache verfasster Text? So manch angehender Biophysiker hätte sich den englischen 'Biophysics' von Cotterill schon lange als deutsche Übersetzung gewünscht. Hier ist sie: sorgfältig strukturiert und ausgewogen wie das englische Original, mit dem Vorzug der schnelleren Erfaßbarkeit. Vom Molekül bis zum Bewusstsein deckt der "Cotterill" alle Ebenen ab. Er setzt nur wenig Grundwissen voraus und ist damit für die Einführungsvorlesung nach dem Vordiplom ideal. Zusätzliche Anhänge mit mathematischen und physikalischen Grundlagen machen das Lehrbuch auch für Chemiker und Biologen attraktiv.

NMR Probeheads for Biophysical and Biomedical Experiments

Theoretical Principles and Practical Guidelines Second Edition

Author: Joël Mispelter,Mihaela Lupu,André Briguet

Publisher: World Scientific Publishing Company

ISBN: 1783268042

Category: Technology & Engineering

Page: 756

View: 906

NMR Probeheads for Biophysical and Biomedical Experiments 2nd Edition is essential reading for anyone in the field of NMR or MRI, from students to medical or biological scientists performing experiments under certain physical and/or geometrical conditions, unattainable by conventional or available probes. The material guides the reader through the most basic and comprehensive stages in accomplishing a correct probe design, from a very basic oscillating circuit to much more elaborate designs. This new edition has been revised and updated to include a chapter dedicated to RF components, which are commonly used for probes realization and their frequency-dependent characteristics. Another completely revised chapter concerns the multiple coil systems and discusses arrays coils, different decoupling methods, and some principles for interfacing coils with low-noise preamplifiers. The principles of linear circuit analysis are presented in a dedicated chapter. Last but not least, accompanying files containing updated software for probe design have been made available from the publisher's website. Request Inspection Copy

Kurze Antworten auf große Fragen

Author: Stephen Hawking

Publisher: Klett-Cotta

ISBN: 3608115102

Category: Political Science

Page: 160

View: 7309

Stephen Hawkings Vermächtnis In seinem letzten Buch gibt Stephen Hawking Antworten auf die drängendsten Fragen unserer Zeit und nimmt uns mit auf eine persönliche Reise durch das Universum seiner Weltanschauung. Seine Gedanken zu Ursprung und Zukunft der Menschheit sind zugleich eine Mahnung, unseren Heimatplaneten besser vor den Gefahren unserer Gegenwart zu schützen. Zugänglich und klar finden Sie in diesem Buch Hawkings Antworten auf die drängendsten Fragen unserer Zeit. - Warum gibt es uns Menschen überhaupt? - Und woher kommen wir? - Gibt es im Weltall andere intelligente Lebewesen? - Existiert Gott? - In welchem Zustand befindet sich unser Heimatplanet? - Werden wir auf der Erde überleben? - Retten oder zerstören uns Naturwissenschaften und Technik? - Hilft uns die künstliche Intelligenz, die Erde zu bewahren? - Können wir den Weltraum bevölkern? - Wie werden wir die Schwächsten – Kinder, Kranke, alte Menschen – schützen? - Wie werden wir unsere Kinder erziehen? Brillanter Physiker, revolutionärer Kosmologe, unerschütterlicher Optimist. Für Stephen Hawking bergen die Weiten des Universums nicht nur naturwissenschaftliche Geheimnisse. In seinem persönlichsten Buch beantwortet der Autor die großen Fragen des menschlichen Lebens und spricht die wichtigsten Themen unserer Zeit an. Zugänglich und klar erläutert er die Folgen des menschlichen Fortschritts – vom Klimawandel bis hin zu künstlicher Intelligenz – und diskutiert seine Gefahren. Hier finden Sie Hawkings Antworten auf die Urfragen der Menschheit. Ein großer Appell an politische Machthaber und jeden Einzelnen von uns, unseren bedrohten Heimatplaneten besser zu schützen.

Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics

Lecture Notes of the Les Houches Summer School 2004

Author: Didier Chatenay,Simona Cocco,Remi Monasson

Publisher: Gulf Professional Publishing

ISBN: 9780444520814

Category: Computers

Page: 354

View: 2463

Dedicated to the multiple aspects, that is, biological, physical and computational of DNA and RNA molecules, this book is divided into three main sections. It is intended to be a reference for advanced graduate students or young researchers to acquire an interdisciplinary understanding of the multiple aspects of DNA and RNA.

Biocolloids

A Textbook for an Introductory Course with Laboratory Experiments

Author: Martin William Lisse

Publisher: N.A

ISBN: N.A

Category: Biochemistry

Page: 318

View: 2367


Introduction to Proteins

Structure, Function, and Motion

Author: Amit Kessel,Nir Ben-Tal

Publisher: CRC Press

ISBN: 9781439810729

Category: Medical

Page: 654

View: 1612

As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.

The Nonlinear Universe

Chaos, Emergence, Life

Author: Alwyn C. Scott

Publisher: Springer Science & Business Media

ISBN: 3540341536

Category: Science

Page: 364

View: 8819

Written in Alwyn Scott’s inimitable style, one that readers will find both lucid and accessible, this masterwork elucidates the explosion of activity in nonlinear science in recent decades. The book explains the wide-ranging implications of nonlinear phenomena for future developments in many areas of modern science, including mathematics, physics, engineering, chemistry, biology, and neuroscience. Arguably as important as quantum theory, modern nonlinear science is essential for understanding the scientific developments of the twenty-first century.

Nanophysik und Nanotechnologie

Eine Einführung in die Konzepte der Nanowissenschaft

Author: Edward L. Wolf

Publisher: John Wiley & Sons

ISBN: 3527687386

Category: Technology & Engineering

Page: 328

View: 2004

Noch hat das Motto “Alles muss kleiner werden” nicht an Faszination verloren. Physikern, Ingenieuren und Medizinern erschließt sich mit der Nanotechnologie eine neue Welt mit faszinierenden Anwendungen. E.L. Wolf, Physik-Professor in Brooklyn, N.Y., schrieb das erste einführende Lehrbuch zu diesem Thema, in dem er die physikalischen Grundlagen ebenso wie die Anwendungsmöglichkeiten der Nanotechnologie diskutiert. Mittlerweile ist es in der 3. Aufl age erschienen und liegt jetzt endlich auch auf Deutsch vor. Dieses Lehrbuch bietet eine einzigartige, in sich geschlossene Einführung in die physikalischen Grundlagen und Konzepte der Nanowissenschaften sowie Anwendungen von Nanosystemen. Das Themenspektrum reicht von Nanosystemen über Quanteneff ekte und sich selbst organisierende Strukturen bis hin zu Rastersondenmethoden. Besonders die Vorstellung von Nanomaschinen für medizinische Anwendungen ist faszinierend, wenn auch bislang noch nicht praktisch umgesetzt. Der dritten Aufl age, auf der diese Übersetzung beruht, wurde ein neuer Abschnitt über Graphen zugefügt. Die Diskussion möglicher Anwendungen in der Energietechnik, Nanoelektronik und Medizin wurde auf neuesten Stand gebracht und wieder aktuelle Beispiele herangezogen, um wichtige Konzepte und Forschungsinstrumente zu illustrieren. Der Autor führt mit diesem Lehrbuch Studenten der Physik, Chemie sowie Ingenieurwissenschaften von den Grundlagen bis auf den Stand der aktuellen Forschung. Die leicht zu lesende Einführung in dieses faszinierende Forschungsgebiet ist geeignet für fortgeschrittene Bachelor- und Masterstudenten mit Vorkenntnissen in Physik und Chemie. Stimmen zur englischen Vorauflage „Zusammenfassend ist festzustellen, dass Edward L. Wolf trotz der reichlich vorhandenen Literatur zur Nanotechnologie ein individuell gestaltetes einführendes Lehrbuch gelungen ist. Es eignet sich – nicht zuletzt dank der enthaltenen Übungsaufgaben – bestens zur Vorlesungsbegleitung für Studierende der Natur- und Ingenieurwissenschaften sowie auch spezieller nanotechnologisch orientierter Studiengänge.“ Physik Journal „... eine sehr kompakte, lesenswerte und gut verständliche Einführung in die Quantenmechanik sowie ihre Auswirkungen auf die Materialwissenschaften ...“ Chemie Ingenieur Technik

Physical Principles of Medical Ultrasonics

Author: C. R. Hill,J. C. Bamber,G. R. ter Haar

Publisher: John Wiley & Sons

ISBN: 047009396X

Category: Medical

Page: 528

View: 7592

The physical properties of ultrasound, particularly its highly directional beam behaviour, and its complex interactions with human tissues, have led to its becoming a vitally important tool in both investigative and interventional medicine, and one that still has much exciting potential. This new edition of a well-received book treats the phenomenon of ultrasound in the context of medical and biological applications, systematically discussing fundamental physical principles and concepts. Rather than focusing on earlier treatments, based largely on the simplifications of geometrical acoustics, this book examines concepts of wave acoustics, introducing them in the very first chapter. Practical implications of these concepts are explored, first the generation and nature of acoustic fields, and then their formal descriptions and measurement. Real tissues attenuate and scatter ultrasound in ways that have interesting relationships to their physical chemistry, and the book includes coverage of these topics. Physical Principles of Medical Ultrasonics also includes critical accounts and discussions of the wide variety of diagnostic and investigative applications of ultrasound that are now becoming available in medicine and biology. The book also encompasses the biophysics of ultrasound, its practical applications to therapeutic and surgical objectives, and its implications in questions of hazards to both patient and operator.