Fundamentals of Enzyme Kinetics

Author: Athel Cornish-Bowden

Publisher: Elsevier

ISBN: 1483161196

Category: Science

Page: 244

View: 2682

Fundamentals of Enzyme Kinetics details the rate of reactions catalyzed by different enzymes and the effects of varying the conditions on them. The book includes the basic principles of chemical kinetics, especially the order of a reaction and its rate constraints. The text also gives an introduction to enzyme kinetics - the idea of an enzyme-substrate complex; the Michaelis-Menten equation; the steady state treatment; and the validity of its assumption. Practical considerations, the derivation of steady-state rate equations, inhibitors and activators, and two-substrate reactions are also explained. Problems after the end of each chapter have also been added, as well as their solutions at the end of the book, to test the readers' learning. The text is highly recommended for undergraduate students in biochemistry who wish to study about enzymes or focus completely on enzymology, as most of the mathematics used in this book, which have been explained in detail to remove most barriers of understanding, is elementary.


fundamentals of enzyme deactivation kinetics

Author: Ajit Sadana

Publisher: N.A


Category: Science

Page: 431

View: 1859

Fundamentals of Receptor, Enzyme, and Transport Kinetics (1993)

Author: John C. Matthews

Publisher: CRC Press

ISBN: 135136457X

Category: Medical

Page: 182

View: 4637

Fundamentals of Receptor, Enzyme, and Transport Kinetics is the first book to pull together the most important topics in receptor, enzyme, and transport kinetics into a concise, easy-to-use format. Numerous equations are included, and key equations are graphed. For each graphed equation, important features are carefully explained. The book is organized so that simple material is presented first, providing a firm foundation on which to cover the advanced topics which appear later. Terminology used throughout the book is consistent with that used in scientific literature, and concepts are explained using analogies from daily life. The book also features two important appendices that will be particularly useful learning tools. The first appendix outlines all of the key equations from the text and indicates their use. The second appendix is a set of sample calculation problems and their solutions. Fundamentals of Receptor, Enzyme, and Transport Kinetics is an excellent text/reference for pharmacologists, biological chemists, experimental biologists, neurochemists, neurotoxicologists, physiologists, and toxicologists. It is also suitable as a graduate-level text in pharmacology and medical pharmacology.


Theorie und Methoden

Author: Hans Bisswanger

Publisher: Wiley-Blackwell

ISBN: 9783527300969

Category: Science

Page: 282

View: 2892

Mit diesem Buch verfügen Biochemiker, Biologen und Mediziner - Studierende und Wissenschaftler - über eines der ausführlichsten Werke auf dem Gebiet der Enzymkinetik in aktualisierter und erweiterter Form. Der Text ist eine benutzerfreundliche, ausgewogene Mischung aus Theorie und Praxis. Alle wichtigen theoretischen Aspekte werden auch dem Einsteiger verständlich vermittelt. Dabei wird Wert darauf gelegt, daß stets der Bezug zum biologischen System sichtbar bleibt. Ein ausführlicher methodischer Teil gibt dem Praktiker im Labor eine wertvolle Unterstützung für die optimale Planung und Durchführung seiner Versuche. Methoden zur Bestimmung multipler Gleichgewichte, Kalorimetrie, die Messung schneller Reaktionen sowie elektrochemische und spektroskopische Methoden werden eingehend beschrieben. Das besondere Plus: die CD-ROM mit der weiterentwickelten und benutzerfreundlichen Version des zugehörigen Enzymkinetikprogramms.

Enzyme Technology

Author: Martin F. Chaplin,C. Bucke

Publisher: CUP Archive

ISBN: 9780521348843

Category: Science

Page: 264

View: 6409

This textbook provides a clear and authoritative guide to the principles and practice of the utilization of enzymes in biotechnology. Enzymes have increasingly important applications in the food and pharmaceutical industry, in medicine, and as biosensors.

Enzyme Kinetics: Catalysis and Control

A Reference of Theory and Best-Practice Methods

Author: Daniel L. Purich

Publisher: Elsevier

ISBN: 0123809258

Category: Science

Page: 920

View: 9204

Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Enzyme Kinetics in Drug Metabolism

Fundamentals and Applications

Author: Swati Nagar,Upendra Argikar,Donald Tweedie

Publisher: Humana Press

ISBN: 9781493960460

Category: Medical

Page: 538

View: 9633

Drug metabolism and transport are very important facets within the discipline of pharmaceutical sciences, with enzyme kinetic concepts utilized regularly in characterizing and modeling the disposition and elimination of drugs. Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications focuses on very practical aspects of applying kinetic principles to drug metabolizing enzymes and transporters. Divided into five convenient sections, topics include the fundamental principles of enzyme kinetics, the kinetics of oxidative and conjugative drug metabolizing enzymes and drug transporters, modeling approaches for both drug metabolizing enzymes and transporters including novel systems biology approaches, understanding of variability both experimental and interindividual (pharmacogenomic), and case studies that provide real life examples of applying these principles. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics especially suitable for the novice, in some cases step-by-step, readily reproducible protocols, and insights to help with troubleshooting and avoiding known pitfalls with extensive cross referencing to assist in learning. Authoritative and easily accessible, Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications serves as a very practical teaching tool for novice, non-mathematically trained scientists interested in these fundamental concepts and as an aid for their supervisors in teaching these principles.

Enzyme Kinetics

Principles and Methods

Author: Hans Bisswanger

Publisher: John Wiley & Sons

ISBN: 3527622039

Category: Science

Page: 320

View: 8492

This new, expanded and updated edition of the user-friendly and comprehensive treatise on enzyme kinetics expertly balances theory and practice. This is an indispensable aid for advanced students and professionals working with enzymes, whether biochemists, biotechnologists, chemical biologists, pharmacologists or bioengineers in academia, industry and clinical research.

Comprehensive Enzyme Kinetics

Author: Vladimir Leskovac

Publisher: Springer Science & Business Media

ISBN: 0306483904

Category: Science

Page: 438

View: 9130

Welcome to your study of enzyme kinetics, the subject that underlies all enzymology, which in turn underlies all aspects of biochemistry. This text will give you an introduction to a wide range of topics that constitute the modern enzyme kinetics. This textbook is directed at graduate students in biochemistry, chemistry, and life sciences, for advanced courses in enzyme kinetics, enzymology, and enzyme chemistry. For this reason, the whole book is organized in a systematic and scholarly fashion. It is unlikely that the student will be expected to cover everything in the text, but in a later career she or he may find it an invaluable reference for topics that are needed in practice. The concepts, definitions and detailed algebra of enzyme kinetics are laid out in accurate detail. For that reason, this textbook can also serve as a handbook for enzyme kinetics for research workers in the field. The research worker will find it a useful source, which can be used for solving the daily experimental problems in the laboratory. The preparation of the manuscript for this book was under the constant surveillance of W. Wallace Cleland, Professor of Chemical Science at the University of Wisconsin in Madison, and one of the founders of modern enzyme kinetics. Without his help and advice, this bookwould not be possible. Several versions of the manuscript were constantly corrected and improved by Svetlana Professor of Biochemistry at the University of Novi Sad.

Enzyme Kinetics

From Diastase to Multi-enzyme Systems

Author: Arthur R. Schulz

Publisher: Cambridge University Press

ISBN: 9780521449502

Category: Medical

Page: 246

View: 3235

Problems are included at the end of each chapter and their solutions are found at the end of the book.

A Study of Enzymes

Author: Stephen A. Kuby

Publisher: CRC Press

ISBN: 9780849369872

Category: Medical

Page: 488

View: 543

This comprehensive monograph consists of two parts: Volume I, entitled Enzyme Catalysis, Kinetics, and Substrate Binding; and Volume II, entitled Mechanism of Enzyme Action. Volume I focuses on several aspects of enzyme catalytic behavior, their steady-state and transient-state kinetics, and the thermodynamic properties of substrate binding. Packed with figures, tables, schemes, and photographs, this volume contains over 1,000 references, including references regarding enzymology's fascinating history. This comprehensive book is of particular interest to enzymology students, teachers, and researchers. Volume II presents selected "cutting edge" examples of techniques and approaches being pursued in biochemistry. This up-to-date resource includes 11 chapters, which illustrate important theoretical and practical aspects of enzyme mechanisms. It also features selected examples in which today's most important techniques, ideas, and theories are used to elaborate on the intricate nature of enzyme action mechanisms. This particular volume provides important information for both the novice and the seasoned investigator.

Fundamentals of Enzyme Engineering

Author: Young Je Yoo,Yan Feng,Yong-Hwan Kim,Camila Flor J. Yagonia

Publisher: Springer

ISBN: 9402410260

Category: Technology & Engineering

Page: 209

View: 1441

This book provides a comprehensive introduction to all aspects of enzyme engineering, from fundamental principles through to the state-of-the-art in research and industrial applications. It begins with a brief history, describing the milestones of advancement in enzyme science and technology, before going on to cover the fundamentals of enzyme chemistry, the biosynthesis of enzymes and their production. Enzyme stability and the reaction kinetics during enzymatic reactions are presented to show how enzymes function during catalysis and the factors that affect their activity. Methods to improve enzyme performance are also presented, such as cofactor regeneration and enzyme immobilization. The book emphasizes and elaborates on the performance and characteristics of enzymes at the molecular level. Finally, the book presents recent advances in enzyme engineering and some key industrial application of enzymes addressing the present needs of society. This book presents essential information not only for undergraduate and graduate students, but also for researchers in academia and industry, providing a valuable reference for the development of commercial applications of enzyme technology.

Plant Metabolic Networks

Author: Jörg Schwender

Publisher: Springer Science & Business Media

ISBN: 9780387787459

Category: Science

Page: 339

View: 8685

Plants are the basis for human nutrition and of increasing interest for the chemical industry as a source of chemical feed stocks. Fuels derived from plant biomass will increasingly replace fossil fuels in the future. In order to increase crop productivity, design new plant products, and create new energy crops, there is need for methods of qualitative and quantitative analysis of metabolism which are able to guide the rational re-design of metabolic networks. In this book, recent advances in qualitative and quantitative analysis of metabolism are summarized to give an overview of the current state of knowledge. Principles of the analysis of network structure, flux analysis, and kinetic modeling are described. Analytical methods necessary to produce the data needed for metabolic flux analysis and for kinetic modeling are described. The analysis of larger metabolic networks is only possible by using computer assistance. Therefore each chapter of the book shall also describe software available for this purpose.

Fundamentals of enzymology

Author: Nicholas C. Price,Lewis Stevens

Publisher: Oxford University Press


Category: Science

Page: 526

View: 8760

Now in a new edition, this book provides an up-to-date account of the field of enzymology. it describes the action of enzymes in systems of increasing complexity, and shows how these properties can be best utilized, both clinically and technically. The reader will find in-depth coverage purified enzymes, including full treatment of purification methods, structure, kinetics, mechanism of action, and the control of enzyme activity. The behavior of enzymes in more complex systems is discussed, and the intact cell is thoroughy examined. Fundamentals of Enzymology also provides complete information on enzyme turnover in vivo, clinical aspects of enzymes, and enzyme technology. This new edition pays close attention to new applications of recombinant-DNA technology, and includes the latest information on the production of enzymes, the determination of amin-acid sequences, and the analysis of enzyme structure and function using site-directed mutagenesis.

RÖMPP Lexikon Chemie, 10. Auflage, 1996-1999

Band 2: Cm - G

Author: Jürgen Falbe,Manfred Regitz

Publisher: Georg Thieme Verlag

ISBN: 3131999810

Category: Science

Page: 868

View: 4637

Die bewährte 10. Auflage der RÖMPP Enzyklopädie von 1999 enthält 44.000 Fachbegriffe, 5.000 Seiten in 6 Bänden, 120.000 Querverweise, 65.000 Literaturhinweise sowie 8.000 Abbildungen, Formeln und Tabellen rund um die Chemie und angrenzende Naturwissenschaften. Anwendungsbezogen und praxisnah werden die Stichwörter leicht verständlich erklärt, sodass auch Nicht-Chemiker den RÖMPP praktisch in Ihrem Arbeitsalltag einsetzen können. Folgende Fachgebiete sind in den 6 Bänden enthalten: Abfall, Analytik, Angewandte Chemie, Anorganik, Arbeitssicherheit, Biochemie, Biographien, Biologie, Biotechnologie, Elektrochemie, Farbstoffe, Fette/Tenside/Waschmittel, Firmenportraits, Gesetzgebung, Kohle- und Petrochemie, Labortechnik, Lebensmittelchemie, Makromolekulare Chemie, Medizin, Metallurgie, Mineralogie, Naturstoffe, Nomenklatur, Ökologie, Organik, Organisationen, Pflanzenschutz, Pharmazie, Physik, Physikalische Chemie, Radiochemie, Technische Chemie, Toxikologie und Umweltschutz, Warenzeichen.

Fundamentals of enzymology

rate enhancement, specificity, control, and applications

Author: G. P. Royer

Publisher: John Wiley & Sons


Category: Science

Page: 232

View: 6014

A balanced, intermediate treatise in enzymology that goes beyond the general biochemistry text. Presents principles and applications of enzyme catalysis.

Drug Metabolism

Current Concepts

Author: Corina Ionescu,Mino R. Caira

Publisher: Springer Science & Business Media

ISBN: 9781402041419

Category: Medical

Page: 420

View: 4023

Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.

Protein Engineering Handbook

Author: Stefan Lutz,Uwe Theo Bornscheuer

Publisher: John Wiley & Sons

ISBN: 3527667016

Category: Science

Page: 1015

View: 6875

Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.