Foundations of Structural Biology

Author: Leonard J. Banaszak

Publisher: Elsevier

ISBN: 9780080521848

Category: Science

Page: 168

View: 2490

Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules. Key Features * Explains how to use coordinate databases and atomic coordinates of biological macromolecules * Teaches the skills of stereoviewing * Contains computer-generated stereographics * Describes the principles of symmetry and handedness in proteins and DNA * Introduces metal and lipid binding proteins and DNA-protein interactions * Explains the principles involved in understanding secondary and quaternary structure * Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions

Fundamentals of Molecular Structural Biology

Author: Subrata Pal

Publisher: Academic Press

ISBN: 9780128148556

Category: Science

Page: 500

View: 2588

Fundamentals of Molecular Structural Biology reviews the mathematical and physical foundations of molecular structural biology and, based on these fundamental concepts, utilizes later chapters to describe molecular structure and explain basic genetic mechanisms. Given the increasingly interdisciplinary nature of research, early career researchers and those shifting into an adjacent field often require a "fundamentals" book to get them quickly up to speed on the foundations of a particular field, and this volume fills that niche. Provides a current and easily digestible resource on molecular structural biology, discussing both foundations and the latest advances Addresses critical issues surrounding macromolecular structures, such as structure-based drug discovery, single-particle analysis, computational molecular biology/molecular dynamic simulation, cell signaling and immune response, macromolecular assemblies, and systems biology Presents discussions that ultimately lead the reader toward a more detailed understanding of the basis and origin of disease

Membrane Structural Biology

With Biochemical and Biophysical Foundations

Author: Mary Luckey

Publisher: Cambridge University Press

ISBN: 1107729335

Category: Science

Page: 400

View: 2441

This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.

Foundations of Comparative Genomics

Author: Arcady R. Mushegian

Publisher: Elsevier

ISBN: 9780080546094

Category: Science

Page: 280

View: 7069

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science

Algorithms in Structural Molecular Biology

Author: Bruce R. Donald,Sorin Istrail,Pavel A. Pevzner,Michael S. Waterman

Publisher: MIT Press

ISBN: 0262015595

Category: Computers

Page: 429

View: 6752

An overview of algorithms important to computational structural biology that addresses such topics as NMR and design and analysis of proteins. Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules. Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility. The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

Biological Foundations of Linguistic Communication

Towards a biocybernetics of language

Author: Thomas T. Ballmer

Publisher: John Benjamins Publishing

ISBN: 9027280584

Category: Language Arts & Disciplines

Page: 161

View: 9728

This is the second of two volumes – the first volume being Waltraud Brennenstuhl’s Control and Ability (P&B III:4) – treating biocybernetical questions of language. This book starts out from an investigation of the (neuro-)biological relevancy of natural language from the point of view of grammar and the lexicon. Furthermore, the basic mechanisms of the self-organization of organisms in their environments are discussed, in so far as they lead to linguistic control and abilities.

Foundations of Mathematical Biology

Supercellular Systems

Author: Robert J. Rosen

Publisher: Academic Press

ISBN: 1483271854

Category: Science

Page: 430

View: 8088

Foundations of Mathematical Biology, Volume III, is devoted to the treatment of behavior of whole organisms and groups of organisms. The viewpoint taken throughout the book is a holistic, phenomenological one. That is, the integrated behavior of these organisms and groups of organisms is not, in general, referred back to specific structural properties of interacting subunits (as in a reductionist scheme), but is rather treated on its own terms without invoking the properties of lower levels of organization. The book begins with an overview of organization and control in physiological systems, with emphasis on the mathematical techniques involved in more detailed investigations of specific physiological mechanisms. Separate chapters cover the cardiovascular system, with particular reference to blood flow; gross problems of organic form; a relational overview of physics, biology, and sociology; the automata theory in the context of the central nervous system; and populations of interacting organisms. The final chapter discusses the material presented in the entire work, some of its philosophical presuppositions and implications, and the possibility of constructing a unified theory of mathematical biology.

The Evolutionary Foundations of Economics

Author: Kurt Dopfer

Publisher: Cambridge University Press

ISBN: 9781139443234

Category: Business & Economics

Page: N.A

View: 5935

It is widely recognised that mainstream economics has failed to translate micro consistently into macro economics and to provide endogenous explanations for the continual changes in the economic system. Since the early 1980s, a growing number of economists have been trying to provide answers to these two key questions by applying an evolutionary approach. This new departure has yielded a rich literature with enormous variety, but the unifying principles connecting the various ideas and views presented are, as yet, not apparent. This 2005 volume brings together fifteen original articles from scholars - each of whom has made a significant contribution to the field - in their common effort to reconstruct economics as an evolutionary science. Using meso economics as an analytical entity to bridge micro and macro economics as well as static and dynamic realms, a unified economic theory emerges.

Foundations of Biophilosophy

Author: Martin Mahner,Mario Bunge,Professor Mario Bunge

Publisher: Springer Science & Business Media

ISBN: 9783540618386

Category: Medical

Page: 423

View: 8803

Over the past three decades, the philosophy of biology has emerged from the shadow of the philosophy of physics to become a respectable and thriving philosophical subdiscipline. In their book, the authors take a fresh look at the life sciences and their philosophy from a strictly realist and emergentist-naturalist perspective. They outline a unified and science-oriented philosophical framework that enables them to clarify many foundational and philosophical issues in biology. Thus, this book should be of interest to both life scientists and philosophers and is suitable as a textbook for courses at the advanced levels as well as for independent study.

Foundations of Factor Analysis, Second Edition

Author: Stanley A Mulaik

Publisher: CRC Press

ISBN: 1420099817

Category: Mathematics

Page: 548

View: 1040

Providing a practical, thorough understanding of how factor analysis works, Foundations of Factor Analysis, Second Edition discusses the assumptions underlying the equations and procedures of this method. It also explains the options in commercial computer programs for performing factor analysis and structural equation modeling. This long-awaited edition takes into account the various developments that have occurred since the publication of the original edition. New to the Second Edition A new chapter on the multivariate normal distribution, its general properties, and the concept of maximum-likelihood estimation More complete coverage of descriptive factor analysis and doublet factor analysis A rewritten chapter on analytic oblique rotation that focuses on the gradient projection algorithm and its applications Discussions on the developments of factor score indeterminacy A revised chapter on confirmatory factor analysis that addresses philosophy of science issues, model specification and identification, parameter estimation, and algorithm derivation Presenting the mathematics only as needed to understand the derivation of an equation or procedure, this textbook prepares students for later courses on structural equation modeling. It enables them to choose the proper factor analytic procedure, make modifications to the procedure, and produce new results.

Cognitive Foundations of Natural History

Towards an Anthropology of Science

Author: Scott Atran

Publisher: Cambridge University Press

ISBN: 9780521438711

Category: Science

Page: 360

View: 9754

Inspired by a debate between Noam Chomsky and Jean Piaget, this work traces the development of natural history from Aristotle to Darwin, and demonstrates how the science of plants and animals has emerged from the common conceptions of folkbiology.

Computational Chemistry Methods in Structural Biology

Author: N.A

Publisher: Academic Press

ISBN: 0123864860

Category: Science

Page: 360

View: 3618

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Computational Chemistry methods in Structural Biology. Essential resource for protein chemists This volume features articles on Computational Chemistry methods in Structural Biology

Algorithmic Foundations of Robotics VI

Author: Michael Erdmann,David Hsu,Mark Overmars,A. Frank van der Stappen

Publisher: Springer Science & Business Media

ISBN: 9783540257288

Category: Technology & Engineering

Page: 456

View: 4787

Robot algorithms are abstractions of computational processes that control or reason about motion and perception in the physical world. Because actions in the physical world are subject to physical laws and geometric constraints, the design and analysis of robot algorithms raise a unique combination of questions in control theory, computational and differential geometry, and computer science. Algorithms serve as a unifying theme in the multi-disciplinary field of robotics. This volume consists of selected contributions to the sixth Workshop on the Algorithmic Foundations of Robotics. This is a highly competitive meeting of experts in the field of algorithmic issues related to robotics and automation.

NMR in Structural Biology

A Collection of Papers by Kurt Wuthrich

Author: Kurt Wthrich

Publisher: World Scientific

ISBN: 9789810223847

Category: Science

Page: 760

View: 3247

The volume presents a survey of the research by Kurt Wthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

Foundations of Neuroscience

Author: Marcus Jacobson

Publisher: Springer Science & Business Media

ISBN: 9780306445408

Category: Medical

Page: 387

View: 7412

The author makes a unique contribution to the field by discussing the history and philosophy of the neurosciences, and then developing critical approaches which integrate techniques, theory, and ethics. Taken as a whole, Jacobson's work will provide a coherent and humane framework for future research programs. The paperback edition of this highly successful text, first published in 1993, is now available! The author brings the ethics of neuroscience into a closer relationship with empirical research. Covering the field's history, philosophy, theories, and techniques, this volume provides the necessary moral and ethical framework to evaluate neuroscience research.

Foundations of Biogeography

Classic Papers with Commentaries

Author: Mark V. Lomolino,Dov F. Sax,James H. Brown,International Biogeography Society,National Center for Ecological Analysis and Synthesis

Publisher: University of Chicago Press

ISBN: 9780226492360

Category: Science

Page: 1291

View: 3838

Foundations of Biogeography provides facsimile reprints of seventy-two works that have proven fundamental to the development of the field. From classics by Georges-Louis LeClerc Compte de Buffon, Alexander von Humboldt, and Charles Darwin to equally seminal contributions by Ernst Mayr, Robert MacArthur, and E. O. Wilson, these papers and book excerpts not only reveal biogeography's historical roots but also trace its theoretical and empirical development. Selected and introduced by leading biogeographers, the articles cover a wide variety of taxonomic groups, habitat types, and geographic regions. Foundations of Biogeography will be an ideal introduction to the field for beginning students and an essential reference for established scholars of biogeography, ecology, and evolution. List of Contributors John C. Briggs, James H. Brown, Vicki A. Funk, Paul S. Giller, Nicholas J. Gotelli, Lawrence R. Heaney, Robert Hengeveld, Christopher J. Humphries, Mark V. Lomolino, Alan A. Myers, Brett R. Riddle, Dov F. Sax, Geerat J. Vermeij, Robert J. Whittaker

The Molecular Foundations of Psychiatry

Author: Steven E. Hyman,Eric Jonathan Nestler

Publisher: American Psychiatric Pub

ISBN: 9780880483537

Category: Medical

Page: 239

View: 2176

This text offers a comprehensive introduction to molecular biology, genetics, and neurobiology relevant to psychiatry. Generously illustrated chapters are organized to be read at both an introductory and a more advanced level. Both beginners and advanced professionals will benefit from this text's discussion of how psychotropic drugs work and how gene-environment interactions may contribute to the pathogenesis of psychiatric disorders. The authors demonstrate how molecular investigations in psychiatry will revolutionize the field by leading to improved diagnostic testing, to new and more effective treatments, and ultimately to the development of preventive measures for mental illness.

The Philosophical Foundations of Modern Medicine

Author: K. Lee

Publisher: Springer

ISBN: 0230353258

Category: Science

Page: 233

View: 8824

An exploration of the philosophical foundation of modern medicine which explains why such a medicine possesses the characteristics it does and where precisely its strengths as well as its weaknesses lie. Written in plain English, it should be accessible to anyone who is intellectually curious, lay persons and medical professionals alike.