Foundations of Structural Biology

Author: Leonard J. Banaszak

Publisher: Elsevier

ISBN: 9780080521848

Category: Science

Page: 168

View: 4096

Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules. Key Features * Explains how to use coordinate databases and atomic coordinates of biological macromolecules * Teaches the skills of stereoviewing * Contains computer-generated stereographics * Describes the principles of symmetry and handedness in proteins and DNA * Introduces metal and lipid binding proteins and DNA-protein interactions * Explains the principles involved in understanding secondary and quaternary structure * Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions

Membrane Structural Biology

With Biochemical and Biophysical Foundations

Author: Mary Luckey

Publisher: Cambridge University Press

ISBN: 1107729335

Category: Science

Page: 400

View: 3927

This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.

Algorithms in Structural Molecular Biology

Author: Bruce R. Donald

Publisher: MIT Press

ISBN: 0262297841

Category: Science

Page: 464

View: 6865

Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules.Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility.The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.

Textbook of Structural Biology

Author: Anders Liljas

Publisher: World Scientific

ISBN: 9812772073

Category: Science

Page: 572

View: 3549

A textbook for undergraduate and graduate students in structural biology, chemistry, biochemistry, biology and medicine. It covers various aspects of proteins, nucleic acids and lipids, including the rise and fall of proteins, membranes and gradients, the structural biology of cells, and evolution - the comparative structural biology.

Present at the Flood

How Structural Molecular Biology Came about

Author: Richard Earl Dickerson

Publisher: Sinauer Associates Incorporated

ISBN: 9780878931682

Category: Science

Page: 307

View: 489

Present at the Flood tells the story of the rise of structural molecular biology-proteins and DNA-by immersing the reader in the original papers, written by the scientists who actually did the work. 187 pages from 42 essential scientific papers are reprinted, along with diagrams and commentaries to make them intelligible to the modern reader. The book achieves a personal note because the author was a worker in later years of the field and knew many of the key participants .

Foundations of Osteopathic Medicine

Author: Anthony G. Chila

Publisher: Lippincott Williams & Wilkins

ISBN: 0781766710

Category: Medical

Page: 1131

View: 405

Thoroughly revised for its Third Edition, "Foundations of Osteopathic Medicine" is the most comprehensive, current osteopathic text. This edition features expanded coverage of international practice and includes a new chapter on the structure of the profession.

Evolution As Entropy

Author: Daniel R. Brooks,E. O. Wiley

Publisher: University of Chicago Press

ISBN: 9780226075747

Category: Science

Page: 415

View: 9717

"By combining recent advances in the physical sciences with some of the novel ideas, techniques, and data of modern biology, this book attempts to achieve a new and different kind of evolutionary synthesis. I found it to be challenging, fascinating, infuriating, and provocative, but certainly not dull."—James H, Brown, University of New Mexico "This book is unquestionably mandatory reading not only for every living biologist but for generations of biologists to come."—Jack P. Hailman, Animal Behaviour, review of the first edition "An important contribution to modern evolutionary thinking. It fortifies the place of Evolutionary Theory among the other well-established natural laws."—R.Gessink,TAXON

Foundations of Comparative Genomics

Author: Arcady R. Mushegian

Publisher: Elsevier

ISBN: 9780080546094

Category: Science

Page: 280

View: 4300

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science

Biological Foundations of Emotion

Author: Robert Plutchik,Henry Kellerman

Publisher: Academic Press

ISBN: 1483269647

Category: Psychology

Page: 452

View: 5990

Biological Foundations of Emotion is a detailed account of the relations between brain structure, functions, and emotions based on the results of experimental work and theoretical modeling. A range of issues are examined, such as whether there are structures, circuits, or biochemical events in the brain that control emotional expressions or experience; the effects of lesions and electrical stimulation on emotions; and the role of genetics in the expression of emotion. Comprised of 16 chapters, this volume begins with a presentation of general models of brain functioning. The first chapter deals with the neural substrate for emotion and cites evidence showing that the conventional concept of a limbic system underlying all emotions is not adequate. The discussion then turns to ethological and evolutionary factors of emotion, with emphasis on neuroendocrine patterns of emotional response; ictal symptoms relating to the nature of affects and their cerebral substrate; the anatomy of emotions; and neural systems involved in emotion in primates. Subsequent chapters present different but overlapping brain models of aggression and examine the role of biochemistry in understanding emotions. This book will be of interest to biologists and psychologists.

Foundations of Biophysics

Author: A. L. Stanford

Publisher: Academic Press

ISBN: 1483276449

Category: Science

Page: 404

View: 6812

Foundations of Biophysics serves as an introductory textbook for physical science students to the principles and problems of the life sciences. The book offers to teach physical science students the basic vocabulary of the life sciences and the applications of physics and chemistry to a wide range of biological problems. Topics presented in the book include biological vocabulary and concepts; biological functions at the molecular level of each biological system; and commonly used tools of experimental biophysics. Students in the field of physics, chemistry, biology, and engineering will find the book a good learning material.

Biomolecular Thermodynamics

From Theory to Application

Author: Douglas Barrick

Publisher: CRC Press

ISBN: 1439800200

Category: Medical

Page: 524

View: 5288

"an impressive text that addresses a glaring gap in the teaching of physical chemistry, being specifically focused on biologically-relevant systems along with a practical focus.... the ample problems and tutorials throughout are much appreciated." –Tobin R. Sosnick, Professor and Chair of Biochemistry and Molecular Biology, University of Chicago "Presents both the concepts and equations associated with statistical thermodynamics in a unique way that is at visual, intuitive, and rigorous. This approach will greatly benefit students at all levels." –Vijay S. Pande, Henry Dreyfus Professor of Chemistry, Stanford University "a masterful?tour de force.... Barrick's rigor and scholarship come through in every chapter." –Rohit V. Pappu, Edwin H. Murty Professor of Engineering, Washington University in St. Louis This book provides a comprehensive, contemporary introduction to developing a quantitative understanding of how biological macromolecules behave using classical and statistical thermodynamics. The author focuses on practical skills needed to apply the underlying equations in real life examples. The text develops mechanistic models, showing how they connect to thermodynamic observables, presenting simulations of thermodynamic behavior, and analyzing experimental data. The reader is presented with plenty of exercises and problems to facilitate hands-on learning through mathematical simulation. Douglas E. Barrick is a professor in the Department of Biophysics at Johns Hopkins University. He earned his Ph.D. in biochemistry from Stanford University, and a Ph.D. in biophysics and structural biology from the University of Oregon.

Foundations of Comparative Genomics

Author: Arcady R. Mushegian

Publisher: Elsevier

ISBN: 9780080546094

Category: Science

Page: 280

View: 7883

This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science

Protein Structure and Function

Author: Gregory A. Petsko,Dagmar Ringe

Publisher: New Science Press

ISBN: 0878936637

Category: Science

Page: 195

View: 2842

Published by New Science Press and distributed in the U.S. and Canada by Oxford University PressThis text introduces general principles of protein structure, folding, and function, then goes beyond these basics to tackle the conceptual basis of inferring structure and function from genomic sequence. It is the first book in a series, Primers in Biology, employing a modular design in whichchapters are divided into topics, each occupying one two-page spread that includes the relevant text, illustrations (in full color), definitions, and references.The book has five chapters. The first is an introduction to the principles of protein structure and folding, with emphasis on proteins' biophysical properties. The second describes the principles of the main biochemical functions of proteins, namely binding and catalysis, with a short section on theproperties of structural proteins. Chapter 3 covers the regulation of protein function, containing concise descriptions of all the regulatory mechanisms that operate on proteins, from pH to phosphorylation, with several sections on protein switches based on nucleotide hydrolysis. Chapter 4introduces the principles whereby structure and function are deduced from sequence, with illustrative examples. The final chapter addresses how data on protein structure is gathered, interpreted, and presented.Written for upper-level undergraduates and beginning graduate students, Protein Structure and Function is also be for working scientists needing an up-to-date introduction to the field.

NMR in Structural Biology

A Collection of Papers by Kurt Wuthrich

Author: Kurt Wthrich

Publisher: World Scientific

ISBN: 9789810223847

Category: Science

Page: 760

View: 985

The volume presents a survey of the research by Kurt Wthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding.

Skeletal Muscle Structure, Function, and Plasticity

Author: Richard L. Lieber

Publisher: Lippincott Williams & Wilkins

ISBN: 9780781730617

Category: Medical

Page: 369

View: 8706

In its Second Edition, this text addresses basic and applied physiological properties of skeletal muscle in the context of the physiological effects from clinical treatment. Many concepts are expanded and recent studies on human muscle have been added. This new edition also includes more clinically relevant cases and stories. A two-page full color insert of muscle sections is provided to ensure integral understanding of the concepts presented in the text. Anyone interested in human movement analysis and the understanding of generation and control from the musculoskeletal and neuromuscular systems in implementing movement will find this a valuable resource.

Molecular Biology of the Cell

Author: Bruce Alberts

Publisher: Garland Science

ISBN: 1317563743

Category: Science

Page: 1464

View: 7208

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Biological Foundations of Linguistic Communication

Towards a biocybernetics of language

Author: Thomas T. Ballmer

Publisher: John Benjamins Publishing

ISBN: 9027280584

Category: Language Arts & Disciplines

Page: 161

View: 1691

This is the second of two volumes – the first volume being Waltraud Brennenstuhl’s Control and Ability (P&B III:4) – treating biocybernetical questions of language. This book starts out from an investigation of the (neuro-)biological relevancy of natural language from the point of view of grammar and the lexicon. Furthermore, the basic mechanisms of the self-organization of organisms in their environments are discussed, in so far as they lead to linguistic control and abilities.

Foundations of Mathematical Biology

Supercellular Systems

Author: Robert J. Rosen

Publisher: Academic Press

ISBN: 1483271854

Category: Science

Page: 430

View: 9755

Foundations of Mathematical Biology, Volume III, is devoted to the treatment of behavior of whole organisms and groups of organisms. The viewpoint taken throughout the book is a holistic, phenomenological one. That is, the integrated behavior of these organisms and groups of organisms is not, in general, referred back to specific structural properties of interacting subunits (as in a reductionist scheme), but is rather treated on its own terms without invoking the properties of lower levels of organization. The book begins with an overview of organization and control in physiological systems, with emphasis on the mathematical techniques involved in more detailed investigations of specific physiological mechanisms. Separate chapters cover the cardiovascular system, with particular reference to blood flow; gross problems of organic form; a relational overview of physics, biology, and sociology; the automata theory in the context of the central nervous system; and populations of interacting organisms. The final chapter discusses the material presented in the entire work, some of its philosophical presuppositions and implications, and the possibility of constructing a unified theory of mathematical biology.

Advances in Biological Solid-State NMR

Proteins and Membrane-Active Peptides

Author: Frances Separovic,Akira Naito

Publisher: Royal Society of Chemistry

ISBN: 1849739102

Category: Science

Page: 608

View: 7764

Advances in Biological NMR brings the reader up to date with chapters from international leaders of this growing field, covering the most recent developments in the methodology and applications of solid state NMR to studies of membrane interactions and molecular motions.