Design and Analysis of Cross-Over Trials, Third Edition

Author: Byron Jones,Michael G. Kenward

Publisher: CRC Press

ISBN: 1439861420

Category: Mathematics

Page: 438

View: 4275

Design and Analysis of Cross-Over Trials is concerned with a specific kind of comparative trial known as the cross-over trial, in which subjects receive different sequences of treatments. Such trials are widely used in clinical and medical research, and in other diverse areas such as veterinary science, psychology, sports science, and agriculture. The first edition of this book was the first to be wholly devoted to the subject. The second edition was revised to mirror growth and development in areas where the design remained in widespread use and new areas where it had grown in importance. This new Third Edition: Contains seven new chapters written in the form of short case studies that address re-estimating sample size when testing for average bioequivalence, fitting a nonlinear dose response function, estimating a dose to take forward from phase two to phase three, establishing proof of concept, and recalculating the sample size using conditional power Employs the R package Crossover, specially created to accompany the book and provide a graphical user interface for locating designs in a large catalog and for searching for new designs Includes updates regarding the use of period baselines and the analysis of data from very small trials Reflects the availability of new procedures in SAS, particularly proc glimmix Presents the SAS procedure proc mcmc as an alternative to WinBUGS for Bayesian analysis Complete with real data and downloadable SAS code, Design and Analysis of Cross-Over Trials, Third Edition provides a practical understanding of the latest methods along with the necessary tools for implementation.

Design and Analysis of Cross-Over Trials, Second Edition

Author: Byron Jones,Michael G. Kenward

Publisher: CRC Press

ISBN: 9780412606403

Category: Mathematics

Page: 408

View: 8449

The first edition of Design and Analysis of Cross-Over Trials quickly became the standard reference on the subject and has remained so for more than 12 years. In that time, however, the use of cross-over trials has grown rapidly, particularly in the pharmaceutical arena, and researchers have made a number of advances in both the theory and methods applicable to these trials. Completely revised and updated, the long-awaited second edition of this classic text retains its predecessor's careful balance of theory and practice while incorporating new approaches, more data sets, and a broader scope. Enhancements in the second edition include: A new chapter on bioequivalence Recently developed methods for analyzing longitudinal continuous and categorical data Real-world examples using the SAS system A comprehensive catalog of designs, datasets, and SAS programs available on a companion Web site at www.crcpress.com The authors' exposition gives a clear, unified account of the design and analysis of cross-over trials from a statistical perspective along with their methodological underpinnings. With SAS programs and a thorough treatment of design issues, Design and Analysis of Cross-Over Trials, Second Edition sets a new standard for texts in this area and undoubtedly will be of direct practical value for years to come.

Clinical Trials

A Methodologic Perspective

Author: Steven Piantadosi

Publisher: John Wiley & Sons

ISBN: 1118959205

Category: Mathematics

Page: 920

View: 5516

Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. This book is accompanied by downloadable files available below under the DOWNLOADS tab. These files include: MATHEMATICA program – A set of downloadable files that tracks the chapters, containing code pertaining to each. SAS PROGRAMS and DATA FILES used in the book. The following software programs, included in the downloadables, were developed by the author, Steven Piantadosi, M.D., Ph.D: RANDOMIZATION – This program generates treatment assignments for a clinical trial using blocked stratified randomization. CRM – Implements the continual reassessment methods for dose finding clinical trials. OPTIMAL – Calculates two-stage optimal phase II designs using the Simon method. POWER – This is a power and sample size program for clinical trials. Executables for installing these programs can also be found at https://risccweb.csmc.edu/biostats/. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.

International Workshop on Evidence-Based Technology Enhanced Learning

Author: Pierpaolo Vittorini,Rosella Gennari,Ivana Marenzi,Fernando de la Prieta,Juan M. Corchado Rodríguez

Publisher: Springer Science & Business Media

ISBN: 3642288014

Category: Computers

Page: 142

View: 912

Research on Technology Enhanced Learning (TEL) investigates how information and communication technologies can be designed in order to support pedagogical activities. The workshop proceedings collects contributions concerning evidence based TEL systems, like their design following EBD principles as well as studies or best practices that educators, education stakeholders or psychologists used to diagnose or improve their students' learning skills, including students with specific difficulties. The international ebTEL’12 workshop wants to be a forum in which TEL researchers and practitioners alike can discuss ideas, projects, and lessons related to ebTEL. The workshop takes place in Salamanca, Spain, on March 28th-30th 2012.

Wahrscheinlichkeit

Author: Alʹbert Nikolaevich Shiri︠a︡ev,Hans Jürgen Engelbert

Publisher: N.A

ISBN: N.A

Category: Probabilities

Page: 592

View: 9602


Lebenslinien

Eine Selbstbiographie

Author: Wilhelm Ostwald

Publisher: BoD – Books on Demand

ISBN: 384302233X

Category: Fiction

Page: 808

View: 9666

Wilhelm Ostwald: Lebenslinien. Eine Selbstbiographie Erstdruck: Berlin (Klasing) 1926/1927. Vollständige Neuausgabe. Herausgegeben von Karl-Maria Guth. Berlin 2013. Textgrundlage ist die Ausgabe: Ostwald, Wilhelm: Lebenslinien. Eine Selbstbiographie, 3 Teile, Berlin: Klasing, 1926/1927. Die Paginierung obiger Ausgabe wird in dieser Neuausgabe als Marginalie zeilengenau mitgeführt. Umschlaggestaltung von Thomas Schultz-Overhage unter Verwendung des Bildes: Wilhelm Ostwald (1903). Gesetzt aus Minion Pro, 11 pt. Über den Autor: Neben dessen Gründer Ernst Haeckel war der Freimaurer und Chemie-Nobelpreisträger Wilhelm Ostwald einer der führenden Köpfe des Deutschen Monistenbundes, der eine wissenschaftlich begründbare Weltanschauung nach dem Prinzip der Einheit von Natur und Geist vertrat und dabei christlicher Dogmatik widersprach. Er schlug unter dem Namen »Weltdeutsch« ein vereinfachtes Deutsch als internationale Plansprache vor und setzte sich für ein Weltgeld ein. Nach Differenzen mit der Universität Leipzig legte er seinen Lehrstuhl nieder und lebte als Privatforscher bis zu seinem Lebensende 1932 auf seinem Landsitz in Großbothen.

Angewandte Statistik

Methodensammlung mit R

Author: Lothar Sachs,Jürgen Hedderich

Publisher: Springer-Verlag

ISBN: 3540321616

Category: Mathematics

Page: 702

View: 9196

Computer unterstützen heutzutage die Anwendung statistischer Methoden. Das Programm R ist hierfür ein leicht erlernbares und flexibel einzusetzendes Werkzeug. Die 12., vollständig neu bearbeitete Auflage veranschaulicht Anwendung und Nutzen anhand zahlreicher durchgerechneter Beispiele. Sie erläutert statistische Ansätze und gibt anschaulich und praxisnah Anwendern mit unterschiedlichen Vorkenntnissen die notwendigen Details, um Daten zu gewinnen, zu beschreiben und zu beurteilen. Neben Hinweisen zur Planung und Auswertung von Studien ermöglichen Beispiele, Querverweise und ein ausführliches Sachverzeichnis den gezielten Zugang zur Statistik.

Zeitreihenmodelle

Author: Andrew C. Harvey

Publisher: Walter de Gruyter GmbH & Co KG

ISBN: 3486786741

Category: Business & Economics

Page: 396

View: 9243

Gegenstand des Werkes sind Analyse und Modellierung von Zeitreihen. Es wendet sich an Studierende und Praktiker aller Disziplinen, in denen Zeitreihenbeobachtungen wichtig sind.

Grundbegriffe der Wahrscheinlichkeitsrechnung

Author: A. Kolomogoroff

Publisher: Springer-Verlag

ISBN: 3642498884

Category: Mathematics

Page: 62

View: 8331

Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.

Newtons Werk

Die Begründung der modernen Naturwissenschaft

Author: FAUVEL,FLOOD,SHORTLAND,WILSON

Publisher: Springer-Verlag

ISBN: 3034862237

Category: Juvenile Nonfiction

Page: 325

View: 1764


Matlab für Dummies

Author: Jim Sizemore

Publisher: John Wiley & Sons

ISBN: 352780871X

Category: Computers

Page: 416

View: 4294

Ob Naturwissenschaftler, Mathematiker, Ingenieur oder Datenwissenschaftler - mit MATLAB haben Sie ein mächtiges Tool in der Hand, das Ihnen die Arbeit mit Ihren Daten erleichtert. Aber wie das mit manch mächtigen Dingen so ist - es ist auch ganz schön kompliziert. Aber keine Sorge! Jim Sizemore führt Sie in diesem Buch Schritt für Schritt an das Programm heran - von der Installation und den ersten Skripten bis hin zu aufwändigen Berechnungen, der Erstellung von Grafiken und effizienter Fehlerbehebung. Sie werden begeistert sein, was Sie mit MATLAB alles anstellen können.

Algorithmen für Dummies

Author: John Paul Mueller,Luca Massaron

Publisher: John Wiley & Sons

ISBN: 3527809775

Category: Computers

Page: 320

View: 1227

Wir leben in einer algorithmenbestimmten Welt. Deshalb lohnt es sich zu verstehen, wie Algorithmen arbeiten. Das Buch präsentiert die wichtigsten Anwendungsgebiete für Algorithmen: Optimierung, Sortiervorgänge, Graphentheorie, Textanalyse, Hashfunktionen. Zu jedem Algorithmus werden jeweils Hintergrundwissen und praktische Grundlagen vermittelt sowie Beispiele für aktuelle Anwendungen gegeben. Für interessierte Leser gibt es Umsetzungen in Python, sodass die Algorithmen auch verändert und die Auswirkungen der Veränderungen beobachtet werden können. Dieses Buch richtet sich an Menschen, die an Algorithmen interessiert sind, ohne eine Doktorarbeit zu dem Thema schreiben zu wollen. Wer es gelesen hat, versteht, wie wichtige Algorithmen arbeiten und wie man von dieser Arbeit beispielsweise bei der Entwicklung von Unternehmensstrategien profitieren kann.