The Biogenesis of Cellular Organelles

Author: Chris Mullins

Publisher: Springer Science & Business Media

ISBN: 0387268677

Category: Medical

Page: 181

View: 6226

The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.

Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis

Author: Jean-Pierre Gorvel

Publisher: Springer Science & Business Media

ISBN: 9780306478338

Category: Medical

Page: 301

View: 4517

This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Chapters are grouped into five sections: I. Endocytosis and phagocytosis. Collectively, the chapters of this section review basic knowledge regarding intracellular organelles are involved in membrane interactions with pathogen-containing vacuoles. II. Professional and non-professional phagocytes. Here the authors describe the major differences between the two host cell types, which can be infected by microorganisms. III. Maturation pathways of bacteria-containing vacuoles. Molecular interactions between vacuoles and intracellular organelles leading to the search of the Holy Grail, the replication niche, are described. IV. Host response. Host cells are able to react against intruders and eventually mount host responses. In these chapters the various types of host response mechanisms against intracellular intruders are reviewed. V. Co-evolution. In these final chapters, the question is addressed of whether knowledge of bacteria-host cell interactions will be acquired fast enough to find the necessary tools for controlling microorganism development.

Chloroplast Biogenesis

From Proplastid to Gerontoplast

Author: Udaya C. Biswal,M.K. Raval

Publisher: Springer Science & Business Media

ISBN: 9781402016028

Category: Science

Page: 353

View: 7797

Chloroplast is the organelle where the life-giving process photosynthesis takes place; it is the site where plants and algae produce food and oxygen that sustain our life. The story of how it originates from proplastids, and how it ultimately dies is beautifully portrayed by three authorities in the field: Basanti Biswal, Udaya Biswal and M. K. Raval. I consider it a great privilege and honor to have been asked to write this foreword. The book ' Chloroplast biogenesis: from proplastid to gerontoplast' goes much beyond photosynthesis. The character of the book is different from that of many currently available books because it provides an integrated approach to cover the entire life span of the organelle including its senescence and death. The books available are mostly confined to the topics relating to the 'build up' or development of chloroplast during greening. The story of organelle biogenesis without description of the events associated with its regulated dismantling during genetically programmed senescence is incomplete. A large volume of literature is available in this area of chloroplast senescence accumulated during the last 20 years. Although some of the findings in this field have been organized in the form of reviews, the data in the book are generalized and integrated with simple text and graphics. This book describes the structural features of prop las tid and its transformation to fully mature chloroplast, which is subsequently transformed into gerontoplast exhibiting senescence syndrome. The book consists of five major chapters.

Membrane Biogenesis and Protein Targetting

Author: W. Neupert,R. Lill

Publisher: Elsevier

ISBN: 9780080860824

Category: Science

Page: 340

View: 6739

This book provides a comprehensive overview of recent developments in the fast moving field of protein transport across and into intracellular membranes. The soluble and membrane-bound components assisting in these processes are introduced, and their functions described. Besides a detailed analysis of protein translocation across the bacterial plasma membrane, the mechanisms of protein targeting within the eukaryotic cell are discussed with special focus on the transport of proteins to the endoplasmic reticulum, vacuoles, peroxisomes, mitochondria, and chloroplasts. Providing stimulating hypotheses and models, the book is well suited for advanced students, graduate students, and for newcomers to the field seeking a general, yet accurate introduction to present knowledge in membrane transport of proteins.

Mitochondrial Function and Biogenesis

Author: Carla Koehler,Matthias F. Bauer

Publisher: Springer Science & Business Media

ISBN: 9783540214892

Category: Medical

Page: 333

View: 2984

This book provides the first modern and truly comprehensive coverage of the biochemistry, genetics, and pathology of mitochondria in different organisms. It particularly focuses on the recent advances in our understanding of basic mitochondrial research to the consequences of dysfunction at the molecular level. (Cover)

The Biogenesis of Mitochondria

Transcriptional, Translational and Genetic Aspects

Author: A Kroon

Publisher: Elsevier

ISBN: 0323145515

Category: Science

Page: 574

View: 3804

The Biogenesis of Mitochondria: Transcriptional, Translational and Genetic Aspects covers the symposium, ""Biogenesis of Mitochondria"", held in Rosa Marina near Bari, Italy in June 1973. Organized into three parts, this book first discusses the mechanism, products, and role of mitochondrial DNA in mitochondrial transcription, including the genetic aspects of the process. Subsequent parts elucidate the characteristics of the mitochondrial protein synthetic machinery, as well as the synthesis of mitochondrial proteins.

Biogenesis of Natural Compounds

Author: Peter Bernfeld

Publisher: Elsevier

ISBN: 1483184099

Category: Science

Page: 1224

View: 2100

Biogenesis of Natural Compounds, Second Edition is released to provide updated information on the biogenesis of natural compounds. Most of the chapters in this book are rewritten, and new author contributes a paper on the biogenesis of proteins. This edition also includes a new chapter that deals with the formation of carcinogenic polynuclear hydrocarbons. However, all other chapters are maintained; some of which have modified headings. This edition will help those studying the biogenesis of natural compounds and in need of more updated information compared to those presented in the previous edition.

Eukaryotic RNases and Their Partners in RNA Degradation and Biogenesis

Author: Guillaume Chanfreau,Fuyuhiko Tamanoi

Publisher: Academic Press

ISBN: 0124047408

Category: Medical

Page: 278

View: 6161

This special issue of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. Contributions from leading authorities Informs and updates on all the latest developments in the field

Eukaryotic RNases and their Partners in RNA Degradation and Biogenesis

Author: N.A

Publisher: Academic Press

ISBN: 0124047440

Category: Science

Page: 254

View: 2822

This special volume of The Enzymes is targeted towards researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses Eukaryotic RNases and their partners in RNA degradation and biogenesis. Contributions from leading authorities Informs and updates on all the latest developments in the field

Terpenoids: Structure, Biogenesis, and Distribution

Recent Advances in Phytochemistry

Author: V. C. Runeckles,T. J. Mabry

Publisher: Elsevier

ISBN: 1483220028

Category: Science

Page: 254

View: 9521

Recent Advances in Phytochemistry, Volume 6: Terpenoids: Structure, Biogenesis, and Distribution covers the advances in the chemistry and biochemistry of terpenoids, and the use of information regarding the occurrence of such compounds in genetics and population ecology. The book discusses the applications of physical methods to some structural and stereochemical problems in terpenes and steroids; novel sesquiterpenes isolated in composites; and the chemistry and biogenesis of the quassinoids (Simaroubolides). The text then describes the recent developments in the biosynthesis of plant triterpenes; the mechanisms of indole alkaloid biosynthesis, recognition of intermediacy and sequence by short-term incubation; and the biochemistry and physiology of lower terpenoids. The genetic and biosynthetic relationships of monoterpenes; and the confirmation of a clinal pattern of chemical differentiation in Juniperus virginiana from terpenoid data obtained in successive years are also encompassed. Botanists, biochemists, and people involved in the study of phytochemistry will find the book invaluable.

Mitochondria: Structure, Biogenesis and Transducing Functions

Author: H. Tedeschi

Publisher: Springer Science & Business Media

ISBN: 3709184126

Category: Medical

Page: 164

View: 3813

In the past few years, the body of experimental work on the structure, function and assembly processes of mitochondria has expanded rapidly. No one person can believe himself or herself completely in control of the burgeoning literature without possessing serious omissions or blind spots. In the present monograph I have attempted a critical evaluation of the literature. I believe that the common thread of single authorship outweighs the shortcomings of one person presenting many disparate viewpo,ints. It is my hope that the end product represents a comprehensive and coordinated review of the subject matter to the present date. Although the bulk of this monograph was completed by October 1974, I have made some attempts to update several of the sections at later times. Albany, N. Y. , November 1975 H. TEDESCHI Contents A. Structure of Mitochondria 1. General Organization . a) Conventional Thin Section Electron Microscopy b) Negative Staining Techniques . 3 c) Freeze-Cleavage . . . . . . . 4 2. Special Organization and Inclusions 10 a) Prismatic or Atypical Cristae 10 b) Filaments and Tubules . . 11 c) Amorphous Inclusions 12 d) Intramitochondrial Granules 12 e) DNA Containing Fibers 14 3. Topography of the Mitochondrial Transducing Systems 15 B. The Assembly of Mitochondria 18 1. Mitochondrial DNA and Its Genetic Role 19 2. Transcription of the Mitochondrial DNA . 28 a) mRNA . . . . . . . . . . . . . . 30 b) The Machinery for Transcription and Translation 32 c) Turnover of Mitochondrial RNA 36 3. Protein Synthesis . . . . . . . . 37 a) Mitochondrial Protein Synthesis and Its Characteristics 37 b) Role of Mitochondrial Protein Synthesis . .

Biogenesis of Antibiotic Substances

Author: Zdenko Vanek

Publisher: Elsevier

ISBN: 0323155839

Category: Science

Page: 324

View: 8167

Biogenesis of Antibiotic Substances covers the proceedings of a panel discussion on ""Basic Research and Practical Aspects of Antibiotic Production"" held during the Antibiotic Congress in Prague. This book is organized into 25 chapters that cover the regulating mechanisms of primary antibiotic metabolite biosynthesis. This text describes the relationship between secondary metabolite production and synthesis of cell matter or cell wall. The opening chapters describe the parasexual cycle and some of the ways in which the cycle may be used for strain improvement, as well as the applications of refined techniques of genetic recombination and the principles of biochemical genetics to the field of antibiotics. The next chapter deals with cultural and fermentative characteristics of A-type isolates obtained from progenitor and representative member strains of the Wisconsin Family of Strains of Penicillium chrysogenum. Considerable chapters are devoted to the metabolite biosynthesis, such as geodoxin and related compounds; secondary metabolism of penicillins, gibberellins, and griseofulvin in fungi; and tetracycline metabolites. The book goes on examining the stereochemical aspects of macrolide antibiotics. It also describes the biosynthetic pathways involving ring cleavage of carbocyclic compounds, as well as the biosynthesis of different peptide antibiotics and of actinomycins and its relationship to protein synthesis. The production of phenazines is also explained. Other chapters consider other metabolites, such as those that decarboxylate, the malonate, and the 3-nitropropionic acid. A discussion on the role of carbohydrates and phosphate in the biosynthesis of different types of antibiotics is included. Lastly, microbiological assay procedures for antibiotic research and influencing factors are presented.

Mitochondrial Biogenesis and Genetics

Author: Giuseppe M. Attardi

Publisher: Gulf Professional Publishing

ISBN: 9780121821654

Category: Science

Page: 621

View: 1396

The critically acclaimed laboratory standard for forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerlyawaited, frequently consulted, and praised by researchers and reviewers alike. More than 260 volumes have been published (all of them still in print) and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Key Features * This volume covers methodology used in * Mitochondrial gene expression * Mitochondrial genetics and gene manipulation * Mitochondrial diseases and aging

Molecular Machines Involved in Peroxisome Biogenesis and Maintenance

Author: Cecile Brocard,Andreas Hartig

Publisher: Springer

ISBN: 3709117887

Category: Science

Page: 543

View: 2577

In eukaryotes, lipid metabolism requires the function of peroxisomes. These multitasking organelles are also part of species-specific pathways such as the glyoxylate cycle in yeast and plants or the synthesis of ether lipid in mammals. Proteins required for the biogenesis of peroxisomes typically assemble in large molecular complexes, which participate in membrane formation, protein transport, peroxisome duplication and - inheritance during cell division. Peroxisomal function is essential for life. Mutations in PEX genes, encoding for biogenesis factors, are often associated with lethal disorders. The association of peroxisomes with other organelles suggests an extensive participation in organellar crosstalk. This book represents a state-of-the-art review in the field of peroxisome research encompassing the cell and molecular biology of peroxisome biogenesis and its diseases, the protein complexes involved in this process and the modern technologies applied to study them. The book is intended for graduate students, researchers and lecturers in biochemistry, molecular and cell biology with a biomedical background.

Protein Export and Membrane Biogenesis

Author: R.E. Dalbey

Publisher: Elsevier

ISBN: 9780080526096

Category: Science

Page: 276

View: 8096

The incentive for putting together Volume 4 of this series was to review the wealth of new information that has become available in prokaryotic organisms in protein export and membrane biogenesis. Just in the last several years, protein translocation has now been efficiently reconstituted using defined components and the mechanism by which proteins are moved across membrane bilayers is now being examined at a higher resolution. In addition, because of a new technical breakthrough using osmolytes, it is now possible to reconstitute a number of channel proteins, ATPase, receptors, and transporters. In many cases, it is possible to successfully predict the membrane topology of these types of proteins using both "hydrophobicity analysis" and the "positive inside" rule. In this volume, two chapters focus on protein translocation across membranes (Biochemical Analyses of Components Comprising the Protein Translocation Machinery of E. Coli; Protein Translocation Genetics), while several others on how proteins assemble into the ineer membrane of E. Coli (Membrane Protein Assembly; Membrane Insertion of Small Proteins: Evolutionary and Functional Aspects; Pigment-Protein Complex Assembly in Rhodobacter sphaeroides and Rhodobacter Capsulatus). Other sections review recent progress on transporters (Identification and Reconstitution of Anion Exchange Mechanisms in Bacteria; Helic Packing in the C-Terminal Half of Lactose Permease) and signal transduction (Mechanism of Transmembrane Signaling in Osmoregulation) as well as the assembly of prints into the outer membrane (Export and Assembly of Outer Membrane Proteins in E. coli). Although the emphasis of the book is on proteins, the role of phospholipids in controlling various cell surface processes is reviewed (Role of Phospholipids in coli Cell Function). I should point out the reason for the rapid progress in bacteria research is because of the possibility to apply biochemistry and genetics in this organism.

Protein Transfer and Organelle Biogenesis

Author: Rathindra C. Das

Publisher: Elsevier

ISBN: 0323142168

Category: Science

Page: 866

View: 7860

Protein Transfer and Organelle Biogenesis is a seven-section volume focusing on the property of proteins to carry signals for secretion, mitochondrial assembly, and lysosomal localizations. It describes how these signals function and determines other factors necessary in building and maintaining the functions of a cell. Organized into seven sections encompassing 19 chapters, the book deals with the general aspects of protein translocation, modification, and sorting. It discusses the transport into the endoplasmic reticulum, the role of carbohydrates in glycoprotein trafficking, and the mechanism of endo- and exocytosis. It further discusses the localization of proteins to the mitochondrion and nucleus and with bacterial protein transport. The final section emphasizes the contribution secretion research that the biotechnology industry has made to the production of proteins. Biologists, cell biologists, researchers, teachers, and students who are interested in the mechanism of protein transfer and organelle biogenesis will find this book invaluable.

Prostaglandins, Leukotrienes and Other Eicosanoids

From Biogenesis to Clinical Application

Author: Friedrich Marks,Gerhard F├╝rstenberger

Publisher: John Wiley & Sons

ISBN: 3527613633

Category: Science

Page: 408

View: 696

Polyunsaturated fatty acids are essential for human cell metabolism. As precursors of a very large and extremely versatile family of signaling compounds they play a key role in intracellular communication. Eicosanoids constitute one of the most abundant and prominent subfamilies of these fatty acid derivatives which are formed primarily along oxidative pathways. Prostaglandins, leukotrienes, and related eicosanoids have a modulatory function in mammalian cells and are responsible for tissue responses such as inflammation or wound repair. Increasing activity in eicosanoid research sheds new light on today's most common diseases including atherosclerosis, cancer, Alzheimer's, allergies, and rheumatic diseases. The recent advances already have far-reaching implications in medicine. This detailed account, written by leading experts, covers the ground-breaking developments in recent eicosanoid research. The topics span eicosanoid biogenesis, new aspects of their pathophysiology, for example their influence on the cardiovascular system, as well as the clinical application of synthetic eicosanoids and their antagonists. Researchers and students working in biochemistry or in pharmaceutical, physiological, medicinal and neurochemistry will value this informative introduction to one of the most rapidly developing fields in cell biology.

Biogenesis Of Plant Cell Wall Polysaccharides

Author: Frank Loewus

Publisher: Elsevier

ISBN: 0323152465

Category: Science

Page: 394

View: 8170

Biogenesis of Plant Cell Wall Polysaccharides contains the proceedings of a 1972 symposium on Biogenesis of Plant Cell Wall Polysaccharides held at the 164th National Meeting of the American Chemical Society, New York, New York. The symposium focuses on a broad range of interest from structural to functional aspects of cell wall polysaccharide biosynthesis in algae as well as in higher plants. Organized into 17 chapters, this book details the progress and understanding regarding the biosynthesis of cell wall components and the assembly of these components in the wall. It encompasses topics on cell wall polysaccharides, UDP-D-glucuronic acid pyrophosphorylase, and D-xylose. This reference also tackles the UDP-D-glucuronic acid, L-arabinose, D-apiose, and carbohydrate polymers. Furthermore, it explains other topics, such as on extensin, hydroxyproline-rich glycoprotein, cellulose, and polygalacturonic acid.

Fimbriae Adhesion, Genetics, Biogenesis, and Vaccines

Author: Per Klemm

Publisher: CRC Press

ISBN: 9780849348945

Category: Science

Page: 292

View: 8705

Fimbriae are the best-studied bacterial colonization factors. They are of paramount importance in bacterial pathogenesis and microbial ecology. Due to the advent of new and powerful techniques, an impressive amount of information has been accumulated on these important surface organelles over the last decade. The first book of its kind, Fimbriae brings together into one volume the state of the art of this very active field. Internationally recognized researchers give both a horizontal and lateral approach to fimbriology. Selected types of fimbriae are extensively reviewed and fundamental questions such as evolution, control or regulation, biogenesis, bacteria-host interaction, and fimbriae-based vaccines are examined.